The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction.
Open accessAbstract
Inhibins and activins are dimeric growth factors of the transforming growth factor-beta superfamily, a class of peptides that can regulate the growth and differentiation of a variety of cell types. Recently, activins have been implicated in early vertebrate development through their ability to evoke, in Xenopus embryo explants, both morphological and molecular changes characteristic of mesoderm induction. To understand these processes further, we have used homologous recombination in embryonic stem cells to create mouse strains carrying mutations in the gene encoding the activin/inhibin beta B subunit. These mice are expected to be deficient in activin B (beta B:beta B), activin AB (beta A:beta B), and inhibin B (alpha:beta B). Viable mutant animals were generated, indicating that the beta B subunit is not essential for mesoderm formation in the mouse. Mutant animals suffered, however, from distinct developmental and reproductive defects. An apparent failure of eyelid fusion during late embryonic development led to eye lesions in mutant animals. Whereas beta B-deficient males bred normally, mutant females manifested a profoundly impaired reproductive ability, characterized by perinatal lethality of their offspring. The phenotype of mutant mice suggests that activin beta B (1) plays a role in late fetal development and (2) is critical for female fecundity. In addition, we have found that expression of the related beta A subunit of activin is highly upregulated in ovaries of mutant females. Altered regulation of beta A activin in beta B-deficient mice may contribute to the mutant phenotype.
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Cites
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 46,426
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Self-citationSite-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355
Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
Stewart, C. L., Kaspar, P., Brunet, L. J., Bhatt, H., Gadi, I., Köntgen, F., & Abbondanzo, S. J. (1992) · Nature · doi:10.1038/359076a0 · Cited by 2,034
Doetschman, T. C., Eistetter, H., Katz, M., Schmidt, W., & Kemler, R. (1985) · Development · doi:10.1242/dev.87.1.27 · Cited by 1,962
Simplified mammalian DNA isolation procedure
Laird, P. W., Zijderveld, A., Linders, K., Rudnicki, M. A., Jaenisch, R., & Berns, A. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.15.4293 · Cited by 1,494
Self-citationGenetic variants and strains of the laboratory mouse
(1990) · Choice Reviews Online · doi:10.5860/choice.28-1324 · Cited by 1,483
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T., & Mulligan, R. C. (1991) · Cell · doi:10.1016/0092-8674(91)90011-m · Cited by 1,281
The mouse; its reproduction and development
Rugh, R. (1968) · Medical Entomology and Zoology · Cited by 1,251
Smith, W. C., & Harland, R. M. (1992) · Cell · doi:10.1016/0092-8674(92)90316-5 · Cited by 1,178
Cited by
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Dong, J., Albertini, D. F., Nishimori, K., Kumar, T. R., Lu, N., & Matzuk, M. M. (1996) · Nature · doi:10.1038/383531a0 · Cited by 1,646
Self-citationStat5a is mandatory for adult mammary gland development and lactogenesis.
Liu, X., Robinson, G. W., Wagner, K. U., Garrett, L., Wynshaw-Boris, A., & Hennighausen, L. (1997) · Genes & Development · doi:10.1101/gad.11.2.179 · Cited by 1,111
Crisponi, L., Deiana, M., Loi, A., Chiappe, F., Uda, M., Amati, P., Bisceglia, L., Zelante, L., Nagaraja, R., Porcu, S., et al. (2001) · Nature Genetics · doi:10.1038/84781 · Cited by 990
The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis
McBurney, M. W., Yang, X., Jardine, K., Hixon, M., Boekelheide, K., Webb, J. R., Lansdorp, P. M., & Lemieux, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.38-54.2003 · Cited by 611
Functional analysis of activins during mammalian development
Matzuk, M. M., Kumar, T. R., Vassalli, A., Bickenbach, J. R., Roop, D. R., Jaenisch, R., & Bradley, A. (1995) · Nature · doi:10.1038/374354a0 · Cited by 578
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Metadata
- Authors
- Vassalli, A., Matzuk, M. M., Gardner, H. A., Lee, K. F., & Jaenisch, R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1994-02-15
- Volume
- 8
- Issue
- 4
- Pages
- 414-427
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1992768239
- Cited by
- 398
- References
- 66
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Vassalli, A., Matzuk, M. M., Gardner, H. A., Lee, K. F., & Jaenisch, R. (1994). Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction. Genes & Development. https://doi.org/10.1101/gad.8.4.414
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