The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues.
Open accessAbstract
The neurofibromatosis (NF1) gene shows significant homology to mammalian GAP and is an important regulator of the ras signal transduction pathway. To study the function of NF1 in normal development and to try and develop a mouse model of NF1 disease, we have used gene targeting in ES cells to generate mice carrying a null mutation at the mouse Nf1 locus. Although heterozygous mutant mice, aged up to 10 months, likely attributable to a severe malformation of the heart. Interestingly, mutant embryos also display hyperplasia of neural crest-derived sympathetic ganglia. These results identify new roles for NF1 in development and indicate that some of the abnormal growth phenomena observed in NF1 patients can be recapitulated in neurofibromin-deficient mice.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Consistent with this, Nf1 deficiency induces a myeloproliferative disorder in murine models (8,9).”
From PU.1, Interferon Regulatory Factor (IRF) 2, and the Interferon Consensus Sequence-binding Protein (ICSBP/IRF8) Cooperate to Activate NF1 Transcription in Differentiating Myeloid Cells (2007) · cites this paper as [8]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mutation and cancer: statistical study of retinoblastoma
Knudson, A. G. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.4.820 · Cited by 7,612
(1968) · Medical Entomology and Zoology · Cited by 4,924
Manipulating the mouse embryo: A laboratory manual
Hogan, B. L. M., Costantini, F. D., & Lacy, E. (1986) · Cited by 4,460
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355
Simplified mammalian DNA isolation procedure
Laird, P. W., Zijderveld, A., Linders, K., Rudnicki, M. A., Jaenisch, R., & Berns, A. J. M. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.15.4293 · Cited by 1,497
Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients
Wallace, M. R., Marchuk, D. A., Andersen, L. B., Letcher, R., Odeh, H. M., Saulino, A. M., Fountain, J. W., Brereton, A., Nicholson, J. M., Mitchell, A. L., et al. (1990) · Science · doi:10.1126/science.2134734 · Cited by 1,478
Von Recklinghausen Neurofibromatosis
Riccardi, V. M. (1981) · New England Journal of Medicine · doi:10.1056/nejm198112313052704 · Cited by 1,353
Neural Crest Cells Contribute to Normal Aorticopulmonary Septation
Kirby, M. L., Gale, T. F., & Stewart, D. E. (1983) · Science · doi:10.1126/science.6844926 · Cited by 1,118
The neurofibromatosis type 1 gene encodes a protein related to GAP
Xu, G., O'Connell, P., Viskochil, D., Cawthon, R., Robertson, M., Culver, M., Dunn, D., Stevens, J., Gesteland, R., White, R., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90024-9 · Cited by 1,095
Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus
Viskochil, D. H., Buchberg, A. M., Xu, G., Cawthon, R., Stevens, J., Wolff, R. K., Culver, M., Carey, J. C., Copeland, N. G., Jenkins, N. A., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90252-a · Cited by 1,082
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- 1986, Neurofibromatosis and cancer., Ann. N.Y. Acad. Sci., 486, 56
- 1972, Birth defects: Original article series, 8, 92
Cited by
Sorted by citations
Items 401–500 of 640
Gutmann, D. H. (1998) · Seminars in Pediatric Neurology · doi:10.1016/s1071-9091(98)80006-5 · Cited by 15
Modeling myeloid leukemia tumor suppressor gene inactivation in the mouse
Shannon, K., Beau, M. M. L., Largaespada, D. A., & Killeen, N. P. (2001) · Seminars in Cancer Biology · doi:10.1006/scbi.2001.0372 · Cited by 15
Signal transduction mechanisms in memory disorders
Shalin, S. C., Egli, R. E., Birnbaum, S. G., Roth, T. L., Levenson, J. M., & Sweatt, J. D. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)57003-7 · Cited by 14
Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer
Vasudevan, H. N., Lucas, C. G., Villanueva-Meyer, J. E., Theodosopoulos, P. V., & Raleigh, D. R. (2020) · Neurosurgery · doi:10.1093/neuros/nyaa455 · Cited by 17
Bobyn, J. D., Rasch, A., Mikulec, K., Little, D. G., & Schindeler, A. (2014) · Journal of Orthopaedic Research® · doi:10.1002/jor.22628 · Cited by 14
Xiao, H., Yuan, L., Xu, H., Yang, Z., Huang, F., Song, Z. J., Yang, Y. X., Zeng, C. C., & Deng, H. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1128-9 · Cited by 14
XRASGRP2 is essential for blood vessel formation during Xenopus development
Suzuki, K. H., Takahashi, S., Haramoto, Y., Onuma, Y., Nagamine, K., Okabayashi, K., Hashizume, K., Iwanaka, T., & Asashima, M. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.092929ks · Cited by 14
Ide, L. U. S., Aylor, R. T., Uce, M. I. L., & Hannon, K. E. S. (1997) · Cited by 14
Lopez, L., & Geva, T. (2016) · doi:10.1002/9781118742440.ch25 · Cited by 14
Myeloid Leukemia: Disease Genes and Mouse Models
Copeland, N. G., & Jenkins, N. A. (1999) · KARGER eBooks · doi:10.1159/000062003 · Cited by 14
Self-citationMolecular Determinants of Cardiac Development and Congenital Disease
Harvey, R. P. (2002) · Elsevier eBooks · doi:10.1016/b978-012597951-1/50020-2 · Cited by 14
The role of RalA in biology and therapy of ovarian cancer.
Wang, K., Terai, K., Peng, W., Rouyanian, A., Liu, J., Roby, K. F., Al, W., Ezzeldin, M., Larson, J. A., Ra, W., et al. (2013) · Oncotarget · doi:10.18632/oncotarget.1435 · Cited by 13
Ruiz‐DeDiego, I., Fasano, S., Solís, Ó., García-Montes, J.-R., Brea, J. M., Loza, M. I., Brambilla, R., & Moratalla, R. (2018) · Scientific Reports · doi:10.1038/s41598-018-33713-3 · Cited by 13
Mund, J. A., Park, S.-J., Smith, A. E., He, Y., Jiang, L., Hawley, E., Roberson, M. J., Mitchell, D. K., Abu-Sultanah, M., Yuan, J., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010981 · Cited by 14
Genetic Architecture of Declarative Memory
Bearden, C. E., Karlsgodt, K. H., Bachman, P., van Erp, T. G. M., Winkler, A. M., & Glahn, D. C. (2011) · The Neuroscientist · doi:10.1177/1073858411415113 · Cited by 13
Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders
Rahn, R. M., Weichselbaum, C. T., Gutmann, D. H., Dougherty, J. D., & Maloney, S. E. (2021) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-021-09359-0 · Cited by 13
Regulation of neurofibromin expression in rat sciatic nerve and cultured Schwann cells
Wrabetz, L. G., Feltri, M. L., Kim, H., Daston, M. M., Kamholz, J. A., Scherer, S. S., & Ratner, N. (1995) · Glia · doi:10.1002/glia.440150104 · Cited by 13
Self-citationVariation of iron loading expression in C282Y homozygous haemochromatosis probands and sib pairs
Mura, C., Gac, G. L., Scotet, V., Raguenes, O., Mercier, A.-Y., & Férec, C. (2001) · Journal of Medical Genetics · doi:10.1136/jmg.38.9.632 · Cited by 13
Aetiology of spinal deformities in neurofibromatosis 1: new hypotheses
Abdel-Wanis, M. E.-S., & Kawahara, N. (2001) · Medical Hypotheses · doi:10.1054/mehy.2000.1232 · Cited by 13
Cell Lineages and Tissue Boundaries in Cardiac Arterial and Venous Poles
Ausoni, S., & Sartore, S. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.3.312 · Cited by 14
MacLellan, W. R., & Schneider, M. D. (1999) · Elsevier eBooks · doi:10.1016/b978-012329860-7/50025-8 · Cited by 13
Nf1 mutation disrupts activity-dependent oligodendroglial plasticity and motor learning in mice
Pan, Y., Hysinger, J. D., Yalçın, B., Lennon, J., Byun, Y. G., Raghavan, P., Schindler, N. F., Anastasaki, C., Chatterjee, J., Ni, L., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01654-y · Cited by 13
RASopathies – what they reveal about RAS/MAPK signaling in skeletal muscle development
Rauen, K. A., & Tidyman, W. E. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050609 · Cited by 12
Unraveling neuronal and metabolic alterations in neurofibromatosis type 1
Botero, V., & Tomchik, S. M. (2024) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-024-09565-6 · Cited by 12
Abdel-Wanis, M. E.-S., & Kawahara, N. (2002) · Medical Hypotheses · doi:10.1054/mehy.2001.1467 · Cited by 12
Summers, M. A., Vasiljevski, E. R., Mikulec, K., Peacock, L., Little, D. G., & Schindeler, A. (2018) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2018.02.009 · Cited by 12
Recent progress in the molecular genetics of congenital heart defects
Belmont, J. W. (1998) · Clinical Genetics · doi:10.1111/j.1399-0004.1998.tb03685.x · Cited by 12
Afshinnia, F., Vega-Warner, V., & Killen, P. (2013) · Clinical Kidney Journal · doi:10.1093/ckj/sft010 · Cited by 12
Genetics of Neurofibromatosis 1-Associated Peripheral Nerve Sheath Tumors
Stephens, K. G. (2003) · Cancer Investigation · doi:10.1081/cnv-120025093 · Cited by 12
Animal models of congenital defects in the ventriculoarterial connection of the heart
Ya, J., Schilham, M. W., Clevers, H. C., Moorman, A. F. M., & Lamers, W. H. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050140 · Cited by 12
Brain injury drives optic glioma formation through neuron-glia signaling
Chatterjee, J., Koleske, J. P., Chao, A., Sauerbeck, A. D., Chen, J., Qi, X., Ouyang, M., Boggs, L. G., Idate, R., Marquez, L. I. M. Y., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01735-w · Cited by 11
Gomez, M. P. A., & Batista, O. I. (2015) · Revista médica de Chile · doi:10.4067/s0034-98872015001000011 · Cited by 13
Alanne, M. H., Siljamäki, E., Peltonen, S. A., Väänänen, K., Windle, J. J., Parada, L. F., Määttä, J. A., & Peltonen, J. T. K. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24088 · Cited by 12
Self-citationParticularly Interesting Cysteine- and Histidine-Rich Protein in Cardiac Development and Remodeling
Liang, X., Sun, Y., & Chen, J. (2009) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e3181c5e31d · Cited by 11
Murine tumor suppressor models
Venkatachalam, S., & Donehower, L. A. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(98)00018-9 · Cited by 11
The Heart in Ras-MAPK Pathway Disorders
Digilio, M. C., Marino, B., Sárközy, A., Versacci, P., & Dallapiccola, B. (2008) · Monographs in human genetics · doi:10.1159/000164847 · Cited by 10
Jochmanová, I., & Lazúrová, I. (2014) · Biomedical Papers · doi:10.5507/bp.2014.021 · Cited by 10
Doucet, E., Grychowska, K., Zajdel, P., Bockaert, J., Marin, P., & Bécamel, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810178 · Cited by 10
Osuala, K. O., Baker, C. N., Nguyen, H., Martinez, C., Weinshenker, D., & Ebert, S. N. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00180.2011 · Cited by 10
Challenges in Drug Discovery for Neurofibromatosis Type 1-Associated Low-Grade Glioma
Ricker, C. A., Pan, Y., Gutmann, D. H., & Keller, C. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00259 · Cited by 10
Microdeletion in the FMR-1 gene: an apparent null allele using routine clinical PCR amplification
Hegde, M., Chong, B., Fawkner, M., Lambiris, N., Peters, H., Kenneson, A., Warren, S. T., Love, D. R., & McGaughran, J. M. (2001) · Journal of Medical Genetics · doi:10.1136/jmg.38.9.624 · Cited by 10
A high-resolution map of the chromosomal region surrounding the nude gene
Blackburn, C. C., Griffith, J., & Morahan, G. (1995) · Genomics · doi:10.1016/0888-7543(95)80215-8 · Cited by 10
Motor deficits and neurofibromatosis type 1 (NF1)‐associated MRI impairments in a mouse model of NF1
Robinson, A., Kloog, Y., Stein, R., & Assaf, Y. (2010) · NMR in Biomedicine · doi:10.1002/nbm.1546 · Cited by 9
Biofabrication of a three dimensional human‐based personalized neurofibroma model
Roy, V., Lamontagne, R., Talagas, M., Touzel‐Deschênes, L., Khuong, H. T., Saïkali, S., Dupré, N., & Gros‐Louis, F. (2021) · Biotechnology Journal · doi:10.1002/biot.202000250 · Cited by 9
Zhou, P., Chen, T., Fang, Y., Wang, H., Li, M., Ma, P., He, L., Li, Q., Liu, T., Yang, X., et al. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-1971-0 · Cited by 9
Genetic Predispositions and Childhood Cancer
Shannon, K. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106801 · Cited by 9
Kim, H. A., & Maurel, P. (2009) · Springer protocols handbooks/Springer protocols · doi:10.1007/978-1-60761-292-6_15 · Cited by 9
Srivastava, D. (1999) · Elsevier eBooks · doi:10.1016/b978-012329860-7/50011-8 · Cited by 9
Regulation of Cardiac Development by Receptor Tyrosine Kinases
Tessarollo, L., & Hempstead, B. L. (1998) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(97)00119-9 · Cited by 9
Bone development in neurofibromatosis 1
Abdel-Wanis, M. E.-S., & Kawahara, N. (2003) · Medical Hypotheses · doi:10.1016/s0306-9877(02)00225-6 · Cited by 9
Transgenic mice as research tools in neurocarcinogenesis
Rovigatti, U., Afanasyeva, T., Brandner, S., Hainfellner, J. A., Kiess, M., Maddalena, A. S., Malin, G., Rülicke, T., Steinbach, J. P., Weissenberger, J., et al. (1998) · Journal of NeuroVirology · doi:10.3109/13550289809114516 · Cited by 9
The Contribution of Oxidative Stress to NF1-Altered Tumors
Kuhn, E., Natacci, F., Corbo, M., Pisani, L., Ferrero, S., Bulfamante, G., & Gambini, D. (2023) · Antioxidants · doi:10.3390/antiox12081557 · Cited by 10
Qiao, G., Xuchun, J., Zhang, Y., & Chen, B. (2019) · Europe PMC (PubMed Central) · Cited by 8
Cardiac abnormalities detected by doppler imaging in patients with neurofibromatosis type 1
Tedesco, M. A., Salvo, G. D., Natale, F., Caputo, S., Calabrese, E., Grassia, C., Ratti, G., Iarussi, D., Iacono, A., & Lama, G. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)02062-8 · Cited by 8
Makino, K., Kurita, N., Kanai, M., & Kirita, M. (2013) · Journal of Medical Case Reports · doi:10.1186/1752-1947-7-249 · Cited by 8
Cheng, Y. (2012) · InTech eBooks · doi:10.5772/1337 · Cited by 9
Dirks, P. B. (2005) · Springer eBooks · doi:10.1007/978-88-470-2121-1_1 · Cited by 8
Uhlmann, E. J., & Gutmann, D. H. (2001) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:34:1:61 · Cited by 8
The Neurofibromatosis Type 1 (NF1) Tumor Suppressor Gene and Myeloid Leukemia
Largaespada, D. A., Brannan, C. I., Shaughnessy, J. D., Jenkins, N. A., & Copeland, N. G. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-85232-9_23 · Cited by 8
Self-citationBirth Characteristics Among Children Diagnosed with Neurofibromatosis Type 1 and Tuberous Sclerosis
Tettamanti, G., Mogensen, H., Kampitsi, C., Nordgren, A., & Feychting, M. (2021) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2021.08.009 · Cited by 7
Two pathogenic NF1 gene mutations identified in DNA from a child with mild phenotype
Terzi, Y. K., Sirin, B., Hosgor, G., Serdaroğlu, E., Anlar, B., Aysun, S., & Ayter, Ş. (2011) · Child s Nervous System · doi:10.1007/s00381-011-1648-x · Cited by 7
Wolkenstein, P. (2001) · médecine/sciences · doi:10.1051/medsci/200117111158 · Cited by 7
Mouse Models of Inherited Cancer Syndromes
Jahid, S., & Lipkin, S. M. (2010) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2010.08.011 · Cited by 7
Mice lacking neurofibromin develop gastric hyperplasia
Lin, L., Chen, J., Richardson, J. A., & Parada, L. F. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00007.2009 · Cited by 7
Self-citationMcLaughlin, M. E., & Jacks, T. (2003) · Humana Press eBooks · doi:10.1385/1-59259-328-3:223 · Cited by 7
Isolation and Expansion of Schwann Cells from Transgenic Mouse Models
Kim, J. H., & Kim, H. A. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7649-2_3 · Cited by 7
Establishing the anatomic hallmarks of congenitally malformed hearts
Anderson, R. H., Webb, S., & Brown, N. A. (1996) · Trends in Cardiovascular Medicine · doi:10.1016/1050-1738(95)00123-9 · Cited by 7
Animal models for human contiguous gene syndromes and other genomic disorders
Walz, K., Fonseca, P., & Lupski, J. R. (2004) · Genetics and Molecular Biology · doi:10.1590/s1415-47572004000300001 · Cited by 7
Transgenic mice: What are we learning about gene function and neurological disease?
Longo, F. M. (1995) · The Neuroscientist · doi:10.1177/107385849500100601 · Cited by 7
Neurofibromatosis type 1: II. Answers from animal models
Lakkis, M. M., & Tennekoon, G. I. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1142 · Cited by 7
Analyses of Tumor-Suppressor Genes in Germline Mouse Models of CancerPreprint
Wang, J., & Abate-Shen, C. T. (2014) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top069773 · Cited by 7
The impact of RAS on cell differentiation in health and disease
Duval, C. J., Bottone, S., Schaffner‐Reckinger, E., & Abankwa, D. (2025) · Biochemical Journal · doi:10.1042/bcj20253364 · Cited by 6
Rationale for haploinsufficiency correction therapy in neurofibromatosis type 1
Frost, M., Serra, E., Viskochil, D. H., Korf, B. R., Mattson-Hoss, M. K., Croston, G. E., & Sarnoff, H. (2022) · Journal of Translational Genetics and Genomics · doi:10.20517/jtgg.2022.14 · Cited by 6
Wang, D., Wen, X., Xu, L., Chen, Q.-X., Yan, T.-X., Xiao, H., & Xu, X. (2023) · Physiological Genomics · doi:10.1152/physiolgenomics.00024.2023 · Cited by 6
Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development
Wu, B., Wu, B., Benkaci, S., Shi, L., Lu, P., Park, T., Morrow, B. E., Wang, Y., & Zhou, B. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.029683 · Cited by 6
Ibarrola, M., Pérez‐Riera, A. R., & Gonzalez, M. D. (2019) · Oxford Medical Case Reports · doi:10.1093/omcr/omz021 · Cited by 6
Induction of mitotic catastrophe by PKC inhibition in Nf1-deficient cells
Zhou, X., Kim, S., Shen, L., Lee, H., & Chen, C. (2014) · Cell Cycle · doi:10.4161/cc.29297 · Cited by 6
Mouse Models of Frequently Mutated Genes in Acute Myeloid Leukemia
Mohanty, S., & Heuser, M. (2021) · Cancers · doi:10.3390/cancers13246192 · Cited by 6
An Assessment of the Therapeutic Landscape for the Treatment of Heart Disease in the RASopathies
Yi, J.-S., Perla, S., & Bennett, A. M. (2022) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-022-07324-0 · Cited by 6
Hereditary Cancer and Developmental Abnormalities
Ben‐Yosef, T., & Benvenisty, N. (1999) · Neonatology · doi:10.1159/000014188 · Cited by 6
Gene‐Targeting Approaches in the Study of Cellular Processes Involved in Growth or Differentiation
Yamada, G., Sugimura, K., & Stuart, E. T. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.00739.x · Cited by 6
Miyagishima, K. J., Qiao, F., Stasheff, S. F., & Nadal-Nicolás, F. M. (2024) · Vision · doi:10.3390/vision8020031 · Cited by 7
Buchstaller, J., Clapp, D. W., Parada, L. F., & Zhu, Y. (2012) · Springer eBooks · doi:10.1007/978-3-642-32864-0_36 · Cited by 5
Self-citationTranslational/Clinical Studies in Children and Adults with Neurofibromatosis Type 1
Korf, B. R., Widemann, B. C., Acosta, M. T., & Packer, R. J. (2012) · Springer eBooks · doi:10.1007/978-3-642-32864-0_40 · Cited by 5
Karouzaki, S., Peta, C., Tsirimonaki, E., & Mangoura, D. A. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104582 · Cited by 5
Wiesner, S. M., Geurts, J. L., Diers, M. D., Bergerson, R. J., Hasz, D. E., Morgan, K. J., & Largaespada, D. A. (2011) · American Journal of Hematology · doi:10.1002/ajh.22035 · Cited by 5
RhoA Regulation of Cardiomyocyte Differentiation
Kaarbø, M., Crane, D. I., & Murrell, W. G. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/491546 · Cited by 5
Perspectives Series: Molecular Medicine in Genetically Engineered Animals
Rajewsky, K., Gu, H., Kühn, R., Müller, W., Roes, J., & Schwenk, F. (1996) · Cited by 5
Lopez, L. (2009) · doi:10.1002/9781444306309.ch25 · Cited by 5
Neurofibromatosis type 1-dependent alterations in mouse microglia function are not cell-intrinsic
Logiacco, F., Grzegorzek, L. C., Cordell, E., Popp, O., Mertins, P., Gutmann, D. H., Kettenmann, H., & Semtner, M. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01525-w · Cited by 4
Reilly, K. M. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-553-8_6 · Cited by 4
Genetically modified mouse models in cancer studies
Santos, J., Fernández‐Navarro, P., Villa‐Morales, M., González-Sánchez, L., & Fernández‐Piqueras, J. (2008) · Clinical & Translational Oncology · doi:10.1007/s12094-008-0292-8 · Cited by 4
Garza, R. J. D. L., Hudson, R. A., McMahan, C. A., Walter, C. A., & Vogel, K. S. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.11.031 · Cited by 4
Self-citationExperimental therapeutic approaches to peripheral nerve tumors
Riley, J. R., Spiotta, A. M., & Boulis, N. M. (2007) · Neurosurgical FOCUS · doi:10.3171/foc.2007.22.6.3 · Cited by 4
Signaling Pathways in Valve Formation
Grego‐Bessa, J., Pérez-Pomares, J. M., & de la Pompa, J. L. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-381332-9.00019-0 · Cited by 5
Wandler, A. M., & Shannon, K. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031526 · Cited by 4
Fagg, W. S., Liu, N., Braunschweig, U., de Castro, K. L. P., Chen, X., Ditmars, F. S., Widen, S. G., Donohue, J. P., Módis, K., Russell, W. K., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.22.423880 · Cited by 4
Hsu, T.-T., Chen, C.-P., Lin, M.-H., Hung, T.-E., Huang, T., Wang, C.-Y., & Hsueh, Y. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03340-2 · Cited by 3
Wei, X., Rigopoulos, A., Lienhard, M., Pöhle‐Kronawitter, S., Kotsaris, G., Franke, J., Berndt, N., Mejedo, J. O., Wu, H., Boerno, S. T., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45618-z · Cited by 4
Lozano, L. P., Jensen, R., Jennisch, M. K., Pandala, N. G., Jamshidi, F., Boldt, H. C., Tucker, B. A., & Binkley, E. M. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101359 · Cited by 3
Metadata
- Authors
- Brannan, C. I., Perkins, A. S., Vogel, K. S., Ratner, N., Nordlund, M. L., Reid, S. W., Buchberg, A. M., Jenkins, N. A., Parada, L. F., & Copeland, N. G.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1994-05-01
- Volume
- 8
- Issue
- 9
- Pages
- 1019-1029
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2159562139
- Cited by
- 641
- References
- 42
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 17 · 2023: 10 · 2022: 10 · 2021: 19 · 2020: 14 · 2019: 9 · 2018: 16 · 2017: 11 · 2016: 17 · 2015: 14 · 2014: 17 · 2013: 23 · 2012: 33
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Health and Human Services
- James S. McDonnell Foundation
- National Institutes of Health (n01co074101-034)
- National Cancer Institute (N01 CO-74101)
- National Institute of Neurological Disorders and Stroke (NS-28840, R01NS028840)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Neurofibromatosis and Schwannoma Cases
- Health Sciences › Medicine › Oncology › Neuroblastoma Research and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- neurofibromatosis type 1, NF1 gene, neurofibromin, null mutations, cardiac anomalies, neural crest, Ras signaling, developmental abnormalities, mouse model
- MeSH terms
- Alleles, Animals, Base Sequence, Female, Embryonic and Fetal Development, Fetal Heart, Ganglia, Sympathetic, Heart Defects, Congenital, Homozygote, Kidney, Liver, Male, Mice, Inbred C57BL, Mice, Transgenic, Mitotic Index, Molecular Sequence Data, Mutation, Neural Crest, Genes, Neurofibromatosis 1, Gene Targeting, Muscle, Skeletal, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review