Jenkins, Nancy A.

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

Initiative, A. P. C. G., Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M.-C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A.-M., et al. (2012) · Nature

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 2,058

Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia

Boillée, S., Yamanaka, K., Lobsiger, C. S., Copeland, N. G., Jenkins, N. A., Kassiotis, G., Kollias, G., & Cleveland, D. W. (2006) · Science

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 1,623

Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase

Jankowsky, J. L., Fadale, D. J., Anderson, J., Xu, G. M., Gonzales, V., Jenkins, N. A., Copeland, N. G., Lee, M. K., Younkin, L. H., Wagner, S. L., et al. (2004) · Human Molecular Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,575

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., et al. (1996) · Neuron

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,478

ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

Bruijn, L. I., Becher, M. W., Lee, M. K., Anderson, K. L., Jenkins, N. A., Copeland, N. G., Sisodia, S. S., Rothstein, J. D., Borchelt, D. R., Price, D. L., et al. (1997) · Neuron

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 1,341

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

Borchelt, D. R., Ratovitski, T., van Lare, J., Lee, M. K., Gonzales, V., Jenkins, N. A., Copeland, N. G., Price, D. L., & Sisodia, S. S. (1997) · Neuron

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,023

Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice

Lee, M. K., Stirling, W., Xu, Y., Xu, X., Qui, D., Mandir, A. S., Dawson, T. M., Copeland, N. G., Jenkins, N. A., & Price, D. L. (2002) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 824

Identification of Vangl2 and Scrb1 as planar polarity genes in mammals

Montcouquiol, M., Rachel, R. A., Lanford, P. J., Copeland, N. G., Jenkins, N. A., & Kelley, M. W. (2003) · Nature

Genetic and Kidney Cyst DiseasesDevelopmental Biology and Gene Regulation

Cited by 705

Parkinson's Disease α-Synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death

Martin, L. J., Pan, Y., Price, A. C., Sterling, W., Copeland, N. G., Jenkins, N. A., Price, D. L., & Lee, M. K. (2006) · The Journal of Neuroscience

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 684

microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family

Hemesath, T. J., Steingrímsson, E., McGill, G., Hansen, M. J., Vaught, J., Hodgkinson, C. A., Arnheiter, H., Copeland, N. G., Jenkins, N. A., & Fisher, D. E. (1994) · Genes & Development

melanin and skin pigmentationDevelopmental Biology and Gene Regulation

Cited by 673

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues.

Brannan, C. I., Perkins, A. S., Vogel, K. S., Ratner, N., Nordlund, M. L., Reid, S. W., Buchberg, A. M., Jenkins, N. A., Parada, L. F., & Copeland, N. G. (1994) · Genes & Development

Neurofibromatosis and Schwannoma CasesNeuroblastoma Research and Treatments

Cited by 641

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

Ramonet, D., Daher, J. P. L., Lin, B. M., Stafa, K., Kim, J., Banerjee, R., Westerlund, M., Pletnikova, O., Glauser, L., Yang, L., et al. (2011) · PLoS ONE

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 405

Reprogramming of T Cells to Natural Killer–Like Cells upon Bcl11b Deletion

Li, P., Burke, S., Wang, J., Chen, X., Ortiz, M., Lee, S.-C., Lu, D., Campos, L., Goulding, D., Ng, B. L., et al. (2010) · Science

T-cell and B-cell ImmunologyImmune Cell Function and Interaction

Cited by 374

Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development

Nishinakamura, R., Matsumoto, Y., Nakao, K., Nakamura, K., Sato, A., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Scully, S., Lacey, D. L., et al. (2001) · Development

Renal and related cancersDevelopmental Biology and Gene Regulation

Cited by 358

Bcl11a is essential for normal lymphoid development

Liu, P., Keller, J. R., Ortiz, M., Tessarollo, L., Rachel, R. A., Nakamura, T., Jenkins, N. A., & Copeland, N. G. (2003) · Nature Immunology

T-cell and B-cell ImmunologyDevelopmental Biology and Gene Regulation

Cited by 351

Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals

Montcouquiol, M., Sans, N., Huss, D., Kach, J., Dickman, J. D., Forge, A., Rachel, R. A., Copeland, N. G., Jenkins, N. A., Bogani, D., et al. (2006) · The Journal of Neuroscience

Developmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancer

Cited by 322

Nf1 deficiency causes Ras-Dediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

Largaespada, D. A., Brannan, C. I., Jenkins, N. A., & Copeland, N. G. (1996) · Nature Genetics

Neurofibromatosis and Schwannoma CasesProtein Tyrosine Phosphatases

Cited by 284

Persistent Amyloidosis following Suppression of Aβ Production in a Transgenic Model of Alzheimer Disease

Jankowsky, J. L., Slunt, H. H., Gonzales, V., Savonenko, A. V., Wen, J. C., Jenkins, N. A., Copeland, N. G., Younkin, L. H., Lester, H. A., Younkin, S. G., et al. (2005) · PLoS Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 237

CRISPR-Cas9–mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes

Takeda, H., Kataoka, S., Nakayama, M., Ali, M. A. E., Oshima, H., Yamamoto, D., Park, J.-W., Takegami, Y., An, T., Jenkins, N. A., et al. (2019) · Proceedings of the National Academy of Sciences

CRISPR and Genetic EngineeringGenetic factors in colorectal cancer

Cited by 172

The Roles of Initiating Truncal Mutations in Human Cancers: The Order of Mutations and Tumor Cell Type Matters

Levine, A. J., Jenkins, N. A., & Copeland, N. G. (2019) · Cancer Cell

Cancer Genomics and DiagnosticsCancer Immunotherapy and Biomarkers

Cited by 121

Growth/Differentiation Factor-10: A New Member of the Transforming Growth Factor-β Superfamily Related to Bone Morphogenetic Protein-3

Cunningham, N. S., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Reddi, A. H., & Lee, S.-J. (1995) · Growth Factors

TGF-β signaling in diseasesDevelopmental Biology and Gene Regulation

Cited by 104

PEBP2αB/Mouse AML1 Consists of Multiple Isoforms That Possess Differential Transactivation Potentials

Bae, S.-C., Ogawa, E., Maruyama, M., Oka, H., Satake, M., Shigesada, K., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., & Ito, Y. (1994) · Molecular and Cellular Biology

Acute Myeloid Leukemia ResearchGenomics and Chromatin Dynamics

Cited by 52

Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting.

Sakao, Y., Kawai, T., Takeuchi, O., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Takeda, K., & Akira, S. (2000) · Genomics

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 50

Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse

Yamben, I. F., Rachel, R. A., Shatadal, S., Copeland, N. G., Jenkins, N. A., Warming, S., & Griep, A. E. (2013) · Developmental Biology

TGF-β signaling in diseasesDevelopmental Biology and Gene Regulation

Cited by 50