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Requirement for math5 in the development of retinal ganglion cells
Open accessAbstract
math5 is a murine orthologue of atonal, a bHLH proneural gene essential for the formation of photoreceptors and chordotonal organs in Drosophila. The expression of math5 coincides with the onset of retinal ganglion cell (RGC) differentiation. Targeted deletion of math5 blocks the initial differentiation of 80% of RGCs and results in an increase in differentiated amacrine cells. Furthermore, the absence of math5 abolishes the retinal expression of brn-3b and the formation of virtually all brn-3b-expressing RGCs. These results imply that math5 is a proneural gene essential for RGC differentiation and that math5 acts upstream to activate brn-3b-dependent differentiation processes in RGCs.
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Cited by
Yeh, S., Tsai, M.-Y., Xu, Q., Mu, X.-M., Lardy, H., Huang, K.-E., Lin, H., Yeh, S.-D., Altuwaijri, S., Zhou, X., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212474399 · Cited by 668
Self-citationThe RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina
Rodriguez, A. R., de Sevilla Müller, L. P., & Brecha, N. C. (2014) · Journal of Comparative Neurology · doi:10.1002/cne.23521 · Cited by 483
Evolution of eyes and photoreceptor cell types
Arendt, D. (2003) · The International Journal of Developmental Biology · doi:10.1387/ijdb.14756332 · Cited by 430
Cell fate determination in the vertebrate retina
Bassett, E. A., & Wallace, V. A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.05.004 · Cited by 305
A genomic view of the sea urchin nervous system
Burke, R. D., Angerer, L. M., Elphick, M. R., Humphrey, G. W., Yaguchi, S., Kiyama, T., Liang, S., Mu, X., Agca, C., Klein, W. H., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.007 · Cited by 293
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Metadata
- Authors
- Wang, S. W., Kim, B. S., Ding, K., Wang, H., Sun, D., Johnson, R. L., Klein, W. H., & Gan, L.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-01-01
- Volume
- 15
- Issue
- 1
- Pages
- 24-29
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2101728847
- Cited by
- 461
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Wang, S. W., Kim, B. S., Ding, K., Wang, H., Sun, D., Johnson, R. L., Klein, W. H., & Gan, L. (2001). Requirement for math5 in the development of retinal ganglion cells. Genes & Development. https://doi.org/10.1101/gad.855301
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