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Sequential actions of BMP receptors control neural precursor cell production and fate
Open accessAbstract
Bone morphogenetic proteins (BMPs) have diverse and sometimes paradoxical effects during embryonic development. To determine the mechanisms underlying BMP actions, we analyzed the expression and function of two BMP receptors, BMPR-IA and BMPR-IB, in neural precursor cells in vitro and in vivo. Neural precursor cells always express Bmpr-1a, but Bmpr-1b is not expressed until embryonic day 9 and is restricted to the dorsal neural tube surrounding the source of BMP ligands. BMPR-IA activation induces (and Sonic hedgehog prevents) expression of Bmpr-1b along with dorsal identity genes in precursor cells and promotes their proliferation. When BMPR-IB is activated, it limits precursor cell numbers by causing mitotic arrest. This results in apoptosis in early gestation embryos and terminal differentiation in mid-gestation embryos. Thus, BMP actions are first inducing (through BMPR-IA) and then terminating (through BMPR-IB), based on the accumulation of BMPR-IB relative to BMPR-IA. We describe a feed-forward mechanism to explain how the sequential actions of these receptors control the production and fate of dorsal precursor cells from neural stem cells.
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Cites
Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
Cooper, M. K., Porter, J. A., Young, K. E., & Beachy, P. A. (1998) · Science · doi:10.1126/science.280.5369.1603 · Cited by 848
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Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571
Neurogenesis in the embryonic and adult brain: same regulators, different roles
Urbán, N., & Guillemot, F. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00396 · Cited by 493
Hedgehog–GLI signaling and the growth of the brain
Ruiz i Altaba, A., Palma, V., & Dahmane, N. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn704 · Cited by 376
Mechanisms of pattern formation in development and evolution
Salazar-Ciudad, I., Jernvall, J., & Newman, S. A. (2003) · Development · doi:10.1242/dev.00425 · Cited by 334
Bone morphogenetic protein signalling and vertebrate nervous system development
Liu, A., & Niswander, L. A. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1805 · Cited by 332
Metadata
- Authors
- Panchision, D. M., Pickel, J. M., Studer, L., Lee, S.-H., Turner, P. A., Hazel, T. G., & McKay, R. D. G.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-08-15
- Volume
- 15
- Issue
- 16
- Pages
- 2094-2110
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2066090522
- Cited by
- 327
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Panchision, D. M., Pickel, J. M., Studer, L., Lee, S.-H., Turner, P. A., Hazel, T. G., & McKay, R. D. G. (2001). Sequential actions of BMP receptors control neural precursor cell production and fate. Genes & Development. https://doi.org/10.1101/gad.894701
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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