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c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism.
Open accessAbstract
We have explored the role of the tyrosine kinase c-Src in cellular adhesion. Fibroblasts derived from src-/- mice (src-/- fibroblasts) exhibit a reduced rate of spreading on fibronectin. These defect is rescued by expression of wild-type chicken c-Src. Analyses of mutants suggest that c-Src increases the rate of cell spreading in src-/- fibroblasts through a kinase-independent mechanism requiring both the SH3 and SH2 domains. To further address the role of c-Src in adhesion, we examined the activity and subcellular distribution of c-Src during the adhesion of fibroblasts on fibronectin. We observed a transient increase in the specific kinase activity of c-Src accompanied by the partial dephosphorylation of the negative regulatory site Y527. Activation of c-Src is followed by its redistribution to newly formed focal adhesions. These results suggest that the enzymatic activity and subcellular distribution of c-Src are coordinately regulated during cellular adhesion and that c-Src can affect adhesion by a kinase-independent mechanism.
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Cites
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
Schlaepfer, D. D., Hanks, S. K., Hunter, T., & Geer, P. V. D. (1994) · Nature · doi:10.1038/372786a0 · Cited by 1,595
Cited by
Src family kinases in tumor progression and metastasis
Summy, J. M., & Gallick, G. E. (2003) · Cancer and Metastasis Reviews · doi:10.1023/a:1023772912750 · Cited by 827
Src kinases as therapeutic targets for cancer
Kim, L. C., Song, L., & Haura, E. B. (2009) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.129 · Cited by 700
Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion
Carragher, N. O., & Frame, M. C. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.03.011 · Cited by 373
Sieg, D. J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.20.5933 · Cited by 339
Richardson, A., Malik, R. K., Hildebrand, J. D., & Parsons, J. T. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.12.6906 · Cited by 331
Metadata
- Authors
- Kaplan, K. B., Swedlow, J. R., Morgan, D. O., & Varmus, H. E.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1995-06-15
- Volume
- 9
- Issue
- 12
- Pages
- 1505-1517
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1982849870
- Cited by
- 317
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism. https://app.cochat.ai/papers/10.1101/gad.9.12.1505
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- Kaplan, K. B., Swedlow, J. R., Morgan, D. O., & Varmus, H. E. (1995). c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism. Genes & Development. https://doi.org/10.1101/gad.9.12.1505
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
