The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair.
Open accessAbstract
Using a screen designed to identify yeast mutants specifically defective in recombination between homologous chromosomes during meiosis, we have obtained new alleles of the meiosis-specific genes, HOP1, RED1, and MEK1. In addition, the screen identified a novel gene designated MSH5 (MutS Homolog 5). Although Msh5p exhibits strong homology to the MutS family of proteins, it is not involved in DNA mismatch repair. Diploids lacking the MSH5 gene display decreased levels of spore viability, increased levels of meiosis I chromosome nondisjuction, and decreased levels of reciprocal exchange between, but not within, homologs. Gene conversion is not reduced. Msh5 mutants are phenotypically similar to mutants in the meiosis-specific gene MSH4 (Ross-Macdonald and Roeder 1994). Double mutant analysis using msh4 msh5 diploids demonstrates that the two genes are in the same epistasis group and therefore are likely to function in a similar process--namely, the facilitation of interhomolog crossovers during meiosis.
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DNA Mismatch Repair: Functions and Mechanisms
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Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over
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Metadata
- Authors
- Hollingsworth, N. M., Ponte, L., & Halsey, C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1995-07-15
- Volume
- 9
- Issue
- 14
- Pages
- 1728-1739
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2114171007
- Cited by
- 403
- References
- 44
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair. https://app.cochat.ai/papers/10.1101/gad.9.14.1728
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- Hollingsworth, N. M., Ponte, L., & Halsey, C. (1995). MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair. Genes & Development. https://doi.org/10.1101/gad.9.14.1728
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