The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mouse Otx2 functions in the formation and patterning of rostral head.
Open accessAbstract
The anterior part of the vertebrate head expresses a group of homeo box genes in segmentally restricted patterns during embryogenesis. Among these, Otx2 expression covers the entire fore- and midbrains and takes place earliest. To examine its role in development of the rostral head, a mutation was introduced into this locus. The homozygous mutants did not develop structures anterior to rhombomere 3, indicating an essential role of Otx2 in the formation of the rostral head. In contrast, heterozygous mutants displayed craniofacial malformations designated as otocephaly; affected structures appeared to correspond to the most posterior and most anterior domains of Otx expression where Otx1 is not expressed. The homo- and heterozygous mutant phenotypes suggest Otx2 functions as a gap-like gene in the rostral head where Hox code is not present. The evolutionary significance of Otx2 mutant phenotypes was discussed for the innovation of the neurocranium and the jaw.
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Cites
Studies on the structure & development of vertebrates
Goodrich, E. S. (1930) · doi:10.5962/bhl.title.82144 · Cited by 1,082
Neural Crest and the Origin of Vertebrates: A New Head
Gans, C., & Northcutt, R. G. (1983) · Science · doi:10.1126/science.220.4594.268 · Cited by 1,053
Requirement for LIml in head-organizer function
Shawlot, W., & Behringer, R. R. (1995) · Nature · doi:10.1038/374425a0 · Cited by 805
Cited by
Minoux, M., & Rijli, F. M. (2010) · Development · doi:10.1242/dev.040048 · Cited by 507
Cranial neural crest and the building of the vertebrate head
Santagati, F., & Rijli, F. M. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1221 · Cited by 461
Belo, J. A., Bouwmeester, T., Leyns, L., Kertesz, N., Gallo, M., Follettie, M., & De Robertis, E. M. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00125-1 · Cited by 460
PHOG, a candidate gene for involvement in the short stature of Turner syndrome
Ellison, J. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.8.1341 · Cited by 286
Heads or tails: Wnts and anterior–posterior patterning
Yamaguchi, T. P. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00417-1 · Cited by 276
Metadata
- Authors
- Matsuo, I., Kuratani, S., Kimura, C., Takeda, N., & Aizawa, S.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1995-11-01
- Volume
- 9
- Issue
- 21
- Pages
- 2646-2658
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2127510589
- Cited by
- 690
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- diamond
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