Molecular mechanisms of cranial neural crest cell migration and patterning in craniofacial development

Minoux, Maryline; Rijli, Filippo M.

doi:10.1242/dev.040048

Cited by 507Developmental Biology and Gene RegulationCraniofacial Disorders and TreatmentsCleft Lip and Palate Research

Molecular mechanisms of cranial neural crest cell migration and patterning in craniofacial development

Minoux, Maryline, Rijli, Filippo M.·2010·Development

DOI 10.1242/dev.040048

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Abstract

During vertebrate craniofacial development, neural crest cells (NCCs) contribute much of the cartilage, bone and connective tissue that make up the developing head. Although the initial patterns of NCC segmentation and migration are conserved between species, the variety of vertebrate facial morphologies that exist indicates that a complex interplay occurs between intrinsic genetic NCC programs and extrinsic environmental signals during morphogenesis. Here, we review recent work that has begun to shed light on the molecular mechanisms that govern the spatiotemporal patterning of NCC-derived skeletal structures – advances that are central to understanding craniofacial development and its evolution.

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Other mesenchyme clusters contained cells expressing DLX genes, reminiscent of pharyngeal arch (PA) or frontonasal process CNCC-derived mesenchymal cells.
“Other mesenchyme clusters contained cells expressing DLX genes, reminiscent of pharyngeal arch (PA) or frontonasal process CNCC-derived mesenchymal cells (Fig. 2h, Extended Data Fig. 5)13.”
From Hair-bearing human skin generated entirely from pluripotent stem cells (2020) · cites this paper as [13]
Dermal fibroblasts have two embryonic origins: mesoderm cells (body and scalp skin) and cranial neural crest cells (CNCC; facial skin).
“Dermal fibroblasts have two embryonic origins: mesoderm cells (body and scalp skin) and cranial neural crest cells (CNCC; facial skin)13,14.”
From Hair-bearing human skin generated entirely from pluripotent stem cells (2020) · cites this paper as [13]

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Cis-acting elements conserved between mouse and pufferfish Otx2 genes govern the expression in mesencephalic neural crest cells
Kimura, C., Takeda, N., Suzuki, M., Oshimura, M., Aizawa, S., & Matsuo, I. (1997) · Development · doi:10.1242/dev.124.20.3929 · Cited by 83 · see citing works
Evolution of oropharyngeal patterning mechanisms involving Dlx and endothelins in vertebrates
Kuraku, S., Takio, Y., Sugahara, F., Takechi, M., & Kuratani, S. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.02.013 · Cited by 78 · see citing works
In vivo analysis reveals a critical role for neuropilin-1 in cranial neural crest cell migration in chick
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Induction of mirror-image supernumerary jaws in chicken mandibular mesenchyme by Sonic Hedgehog-producing cells
Brito, J. M., Teillet, M., & Douarin, N. M. L. (2008) · Development · doi:10.1242/dev.019125 · Cited by 74 · see citing works
Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development
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Mesenchyme-dependent BMP signaling directs the timing of mandibular osteogenesis
Merrill, A. E., Eames, B. F., Weston, S. J., Heath, T., & Schneider, R. A. (2008) · Development · doi:10.1242/dev.015933 · Cited by 70 · see citing works
phospholipase C, beta 3 is required for Endothelin1 regulation of pharyngeal arch patterning in zebrafish
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A regulatory module embedded in the coding region of Hoxa2 controls expression in rhombomere 2
Tümpel, S., Cambronero, F., Sims, C., Krumlauf, R. K., & Wiedemann, L. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806360105 · Cited by 65 · see citing works
Regionalisation of early head ectoderm is regulated by endoderm and prepatterns the orofacial epithelium
Haworth, K. E., Healy, C., Morgan, P. J., & Sharpe, P. T. (2004) · Development · doi:10.1242/dev.01337 · Cited by 64 · see citing works
Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism
Ruest, L. B., & Clouthier, D. E. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.01.005 · Cited by 63 · see citing works
Gαq and Gα11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme
Ivey, K. N., Tyson, B., Ukidwe, P., McFadden, D. G., Levi, G., Olson, E. N., Srivastava, D., & Wilkie, T. M. (2003) · Developmental Biology · doi:10.1016/s0012-1606(02)00097-0 · Cited by 60 · see citing works
Temporal and spatial delineation of mouse Otx2 functions by conditional self‐knockout
Fossat, N., Chatelain, G., Brun, G., & Lamonerie, T. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400751 · Cited by 60 · see citing works
Rhombomere of origin determines autonomous versus environmentally regulated expression of Hoxa3 in the avian embryo
Saldivar, J. R., Krull, C. E., Krumlauf, R. K., Ariza‐McNaughton, L., & Bronner-Fraser, M. E. (1996) · Development · doi:10.1242/dev.122.3.895 · Cited by 60 · see citing works
Hoxa2 knockdown in Xenopus results in hyoid to mandibular homeosis
Baltzinger, M., Ori, M., Pasqualetti, M., Nardi, I., & Rijli, F. M. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20567 · Cited by 58 · see citing works
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Conservation and Diversity in the cis-Regulatory Networks That Integrate Information Controlling Expression of Hoxa2 in Hindbrain and Cranial Neural Crest Cells in Vertebrates
Tümpel, S., Maconochie, M. K., Wiedemann, L. M., & Krumlauf, R. K. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0665 · Cited by 55 · see citing works

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ERK signalling: A master regulator of cell behaviour, life and fate
Lavoie, H., Gagnon, J., & Therrien, M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0255-7 · Cited by 1,185 · see citing works
The “Domestication Syndrome” in Mammals: A Unified Explanation Based on Neural Crest Cell Behavior and Genetics
Wilkins, A. S., Wrangham, R. W., & Fitch, W. T. (2014) · Genetics · doi:10.1534/genetics.114.165423 · Cited by 751 · see citing works
Epithelial-mesenchymal transitions: insights from development
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Hair-bearing human skin generated entirely from pluripotent stem cells
Lee, J., Rabbani, C. C., Gao, H., Steinhart, M. R., Woodruff, B. M., Pflum, Z. E., Kim, A., Heller, S., Liu, Y., Shipchandler, T. Z., et al. (2020) · Nature · doi:10.1038/s41586-020-2352-3 · Cited by 487 · see citing works
A Switch Between Topological Domains Underlies HoxD Genes Collinearity in Mouse Limbs
Andrey, G., Montavon, T., Mascrez, B., Gonzãlez, F., Noordermeer, D., Leleu, M., Trono, D., Spitz, F., & Duboule, D. (2013) · Science · doi:10.1126/science.1234167 · Cited by 409 · see citing works
Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest
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Dermal fibroblast in cutaneous development and healing
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Comparison of village dog and wolf genomes highlights the role of the neural crest in dog domestication
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Oculo-auriculo-vertebral spectrum: a review of the literature and genetic update
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Mandible and Tongue Development
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Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder
Long, H. K., Osterwalder, M., Welsh, I. C., Hansen, K. L., Davies, J. O. J., Liu, Y. E., Koska, M., Adams, A. T., Aho, R., Arora, N., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.09.001 · Cited by 160 · see citing works
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Meis2 is essential for cranial and cardiac neural crest development
Machoň, O., Mašek, J., Machoňová, O., Krauss, S. J. K., & Kozmík, Z. (2015) · BMC Developmental Biology · doi:10.1186/s12861-015-0093-6 · Cited by 151 · see citing works
Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction
Fang, J., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Takazaki, S., Yamaza, H., Nonaka, K., & Kang, D. (2012) · Bioscience Reports · doi:10.1042/bsr20120097 · Cited by 147 · see citing works
Gene bivalency at Polycomb domains regulates cranial neural crest positional identity
Minoux, M., Holwerda, S. J. B., Vitobello, A., Kitazawa, T., Kohler, H., Stadler, M. B., & Rijli, F. M. (2017) · Science · doi:10.1126/science.aal2913 · Cited by 144 · see citing works
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Neural crest and placode interaction during the development of the cranial sensory system
Steventon, B., Mayor, R., & Streit, A. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.01.021 · Cited by 141 · see citing works
Macropore design of tissue engineering scaffolds regulates mesenchymal stem cell differentiation fate
Swanson, W. B., Omi, M., Zhang, Z., Nam, H. K., Jung, Y., Wang, G., Ma, P. X., Hatch, N. E., & Mishina, Y. M. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120769 · Cited by 140 · see citing works
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7q11.23 dosage-dependent dysregulation in human pluripotent stem cells affects transcriptional programs in disease-relevant lineages
Adamo, A., Atashpaz, S., Germain, P.-L., Zanella, M., D'Agostino, G., Albertin, V., Chenoweth, J., Micale, L., Fusco, C., Unger, C., et al. (2015) · Nature Genetics · doi:10.1038/ng.3169 · Cited by 129 · see citing works
Modular Skeletal Evolution in Sticklebacks Is Controlled by Additive and Clustered Quantitative Trait Loci
Miller, C. T., Glazer, A. M., Summers, B. R., Blackman, B. K., Norman, A. R., Shapiro, M. D., Cole, B., Peichel, C. L., Schluter, D., & Kingsley, D. M. (2014) · Genetics · doi:10.1534/genetics.114.162420 · Cited by 124 · see citing works
Neural crest development: insights from the zebrafish
Rocha, M., Singh, N., Ahsan, K., Beiriger, A., & Prince, V. (2019) · Developmental Dynamics · doi:10.1002/dvdy.122 · Cited by 118 · see citing works
Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish
Sørhus, E., Incardona, J. P., Furmanek, T., Goetz, G., Scholz, N. L., Meier, S., Edvardsen, R. B., & Jentoft, S. (2017) · eLife · doi:10.7554/elife.20707 · Cited by 116 · see citing works
Ezh2 is required for neural crest-derived cartilage and bone formation
Schwarz, D. F., Varum, S., Zemke, M., Schöler, A., Baggiolini, A., Draganova, K., Koseki, H., Schübeler, D., & Sommer, L. (2014) · Development · doi:10.1242/dev.094342 · Cited by 116 · see citing works
Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signalling
Arima, Y., Miyagawa‐Tomita, S., Maeda, K., Asai, R., Seya, D., Minoux, M., Rijli, F. M., Nishiyama, K., Kim, K.-S., Uchijima, Y., et al. (2012) · Nature Communications · doi:10.1038/ncomms2258 · Cited by 115 · see citing works
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Sox9 function in craniofacial development and disease
Lee, Y., & Saint‐Jeannet, J. (2011) · genesis · doi:10.1002/dvg.20717 · Cited by 112 · see citing works
Normalized shape and location of perturbed craniofacial structures in the Xenopus tadpole reveal an innate ability to achieve correct morphology
Vandenberg, L. N., Adams, D. S., & Levin, M. G. (2012) · Developmental Dynamics · doi:10.1002/dvdy.23770 · Cited by 111 · see citing works
Facial Morphogenesis
Marcucio, R., Hallgrímsson, B., & Young, N. M. (2015) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2015.09.001 · Cited by 111 · see citing works
Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development
Jin, Y.-R., Han, X. H., Taketo, M. M., & Yoon, J. K. (2012) · Development · doi:10.1242/dev.075796 · Cited by 106 · see citing works
The issue of the multipotency of the neural crest cells
Dupin, É., Calloni, G. W., Coelho‐Aguiar, J. M., & Douarin, N. M. L. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.03.024 · Cited by 105 · see citing works
Etiology and Pathogenesis of Hemifacial Microsomia
Chen, Q., Zhao, Y., Shen, G., & Dai, J. (2018) · Journal of Dental Research · doi:10.1177/0022034518795609 · Cited by 99 · see citing works
Mouse <i>Hoxa2</i> mutations provide a model for microtia and auricle duplication
Minoux, M., Kratochwil, C. F., Ducret, S., Amin, S., Kitazawa, T., Kurihara, H., Bobola, N., Vilain, N., & Rijli, F. M. (2013) · Development · doi:10.1242/dev.098046 · Cited by 97 · see citing works
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Articular cartilage regeneration: The role of endogenous mesenchymal stem/progenitor cell recruitment and migration
Zhang, S., Hu, B., Liu, W., Wang, P., Lv, X., Chen, S., Liu, H., & Shao, Z. (2019) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2019.11.001 · Cited by 94 · see citing works
Collective cell migration of the cephalic neural crest: The art of integrating information
Théveneau, E., & Mayor, R. (2010) · genesis · doi:10.1002/dvg.20700 · Cited by 94 · see citing works
Analysis of neural crest–derived clones reveals novel aspects of facial development
Kaucká, M., Ivashkin, E. G., Gyllborg, D., Zikmund, T., Tesarova, M., Kaiser, J., Xie, M., Petersen, J., Pachnis, V., Nicolis, S. K., et al. (2016) · Science Advances · doi:10.1126/sciadv.1600060 · Cited by 91 · see citing works
Specification and formation of the neural crest: Perspectives on lineage segregation
Prasad, M. S., Charney, R. M., & García‐Castro, M. I. (2018) · genesis · doi:10.1002/dvg.23276 · Cited by 88 · see citing works
DNA-guided transcription factor cooperativity shapes face and limb mesenchyme
Kim, S., Morgunova, E. Y., Naqvi, S., Goovaerts, S., Bader, M., Koska, M., Popov, A. N., Luong, C., Pogson, A. N., Swigut, T., et al. (2024) · Cell · doi:10.1016/j.cell.2023.12.032 · Cited by 81 · see citing works
Retinoic acid in developmental toxicology: Teratogen, morphogen and biomarker
Piersma, A. H., Hessel, E. V. S., & Staal, Y. C. M. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2017.05.014 · Cited by 87 · see citing works
Skin organoids: a new human model for developmental and translational research
Lee, J., & Koehler, K. R. (2021) · Experimental Dermatology · doi:10.1111/exd.14292 · Cited by 85 · see citing works
Thyroid hormone and retinoic acid interact to regulate zebrafish craniofacial neural crest development
Bohnsack, B. L., & Kahana, A. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.11.005 · Cited by 83 · see citing works
Myosin II promotes the anisotropic loss of the apical domain during Drosophila neuroblast ingression
Simões, S. D. M., Oh, R. Y., Wang, M. F. Z., Fernández‐González, R., & Tepaß, U. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201608038 · Cited by 83 · see citing works
Neurogenesis From Neural Crest Cells: Molecular Mechanisms in the Formation of Cranial Nerves and Ganglia
Méndez‐Maldonado, K., Vega‐López, G. A., Aybar, M. J., & Velasco, I. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00635 · Cited by 82 · see citing works
A Critical Role for PDGFRα Signaling in Medial Nasal Process Development
He, F., & Soriano, P. M. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003851 · Cited by 82 · see citing works
In vivo gene expression profile of guided bone regeneration associated with a microrough titanium surface
Donos, N., Retzepi, M., Wall, I. B., Hamlet, S. M., & Ivanovski, S. (2011) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2010.02105.x · Cited by 78 · see citing works
An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution
Howard, A. G. A., Baker, P. A., Ibarra‐García‐Padilla, R., Moore, J. A., Rivas, L. J., Tallman, J. J., Singleton, E. W., Westheimer, J. L., Corteguera, J. A., & Uribe, R. A. (2021) · eLife · doi:10.7554/elife.60005 · Cited by 77 · see citing works
The vertebrate Hox gene regulatory network for hindbrain segmentation: Evolution and diversification
Parker, H. J., Bronner-Fraser, M. E., & Krumlauf, R. K. (2016) · BioEssays · doi:10.1002/bies.201600010 · Cited by 76 · see citing works
The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development
Shull, L. C., Sen, R., Menzel, J., Goyama, S., Kurokawa, M., & Artinger, K. (2020) · Developmental Biology · doi:10.1016/j.ydbio.2020.02.006 · Cited by 75 · see citing works
Developmental genetic bases behind the independent origin of the tympanic membrane in mammals and diapsids
Kitazawa, T., Takechi, M., Hirasawa, T., Adachi, N., Narboux‐Nême, N., Kume, H., Maeda, K., Hirai, T., Miyagawa‐Tomita, S., Kurihara, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms7853 · Cited by 76 · see citing works
Hedgehog signaling patterns the oral-aboral axis of the mandibular arch
Xu, J., Liu, H., Lan, Y., Adam, M., Clouthier, D. E., Potter, S. S., & Jiang, R. (2019) · eLife · doi:10.7554/elife.40315 · Cited by 73 · see citing works
The canonical Wnt/ß-catenin signaling pathway regulates Fgf signaling for early facial development
Wang, Y., Song, L., & Zhou, C. J. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.11.004 · Cited by 73 · see citing works
Sf3b4-depleted Xenopus embryos: A model to study the pathogenesis of craniofacial defects in Nager syndrome
Devotta, A., Juraver-Geslin, H. A., Gonzalez, J. A., Hong, C., & Saint‐Jeannet, J. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.02.010 · Cited by 72 · see citing works
The nervous system orchestrates and integrates craniofacial development: a review
Adameyko, I., & Fried, K. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00049 · Cited by 69 · see citing works
COLEC10 is mutated in 3MC patients and regulates early craniofacial development
Munye, M. M., Dı́az-Font, A., Ocaka, L., Henriksen, M. L., Lees, M. M., Brady, A., Jenkins, D., Morton, J. E. V., Hansen, S., Bacchelli, C., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006679 · Cited by 71 · see citing works
Trunk neural crest cells: formation, migration and beyond
Vega‐López, G. A., Cerrizuela, S., & Aybar, M. J. (2017) · The International Journal of Developmental Biology · doi:10.1387/ijdb.160408gv · Cited by 71 · see citing works
Fishing for jaws in early vertebrate evolution: a new hypothesis of mandibular confinement
Miyashita, T. (2015) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12187 · Cited by 70 · see citing works
Defective neural crest migration revealed by a Zebrafish model of Alx1-related frontonasal dysplasia
Dee, C., Szymoniuk, C. R., Mills, P. E. D., & Takahashi, T. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds423 · Cited by 70 · see citing works
Coupling the roles of Hox genes to regulatory networks patterning cranial neural crest
Parker, H. J., Pushel, I., & Krumlauf, R. K. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.03.016 · Cited by 68 · see citing works
Shaping faces: genetic and epigenetic control of craniofacial morphogenesis
Selleri, L., & Rijli, F. M. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-023-00594-w · Cited by 68 · see citing works
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ZebRA: An overview of retinoic acid signaling during zebrafish development
Samarut, É., Fraher, D., Laudet, V., & Gibert, Y. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.05.030 · Cited by 66 · see citing works
Segmentation and patterning of the vertebrate hindbrain
Krumlauf, R. K., & Wilkinson, D. G. (2021) · Development · doi:10.1242/dev.186460 · Cited by 64 · see citing works
Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers
Edlund, R. K., Ohyama, T., Kantarci, H., Riley, B. B., & Groves, A. K. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.03.004 · Cited by 63 · see citing works
The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss of Twist1 function
Bildsoe, H., Loebel, D. A. F., Jones, V. J., Hor, A. C. C., Braithwaite, A. W., Chen, Y., Behringer, R. R., & Tam, P. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.12.004 · Cited by 61 · see citing works
A Hox gene regulatory network for hindbrain segmentation.
Parker, H., & Krumlauf, R. (2020) · Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.03.001 · Cited by 54 · see citing works
ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis
Song, E. K., Jeon, J., Jang, D. G., Kim, H. E., Sim, H. J., Kwon, K. Y., Medina-Ruiz, S., Jang, H., Lee, A. R., Rho, J. G., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aam7486 · Cited by 61 · see citing works
Pattern and polarity in the development and evolution of the gnathostome jaw: Both conservation and heterotopy in the branchial arches of the shark, Scyliorhinus canicula
Compagnucci, C., Debiais‐Thibaud, M., Coolen, M., Fish, J. L., Griffin, J. N., Bertocchini, F., Minoux, M., Rijli, F. M., Borday‐Birraux, V., Casañe, D., et al. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.02.022 · Cited by 60 · see citing works
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Hox genes: Downstream “effectors” of retinoic acid signaling in vertebrate embryogenesis
Nolte, C., de Kumar, B., & Krumlauf, R. (2019) · Genesis · doi:10.1002/dvg.23306 · Cited by 52 · see citing works
CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations
Okuno, H., Renault-Mihara, F., Ohta, S., Fukuda, K., Kurosawa, K., Akamatsu, W., Sanosaka, T., Kohyama, J., Hayashi, K., Nakajima, K., et al. (2017) · eLife · doi:10.7554/elife.21114 · Cited by 59 · see citing works
Fuz Regulates Craniofacial Development through Tissue Specific Responses to Signaling Factors
Zhang, Z., Wlodarczyk, B. J., Niederreither, K., Venugopalan, S. R., Florez, S. L., Finnell, R. H., & Amendt, B. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024608 · Cited by 57 · see citing works
Neural crest and the patterning of vertebrate craniofacial muscles
Ziermann, J. M., Diogo, R., & Noden, D. M. (2018) · genesis · doi:10.1002/dvg.23097 · Cited by 52 · see citing works
Metabolism navigates neural cell fate in development, aging and neurodegeneration
Traxler, L., Lagerwall, J., Eichhorner, S., Stefanoni, D., D’Alessandro, A., & Mertens, J. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.048993 · Cited by 57 · see citing works
Tissue Specific Roles for the Ribosome Biogenesis Factor Wdr43 in Zebrafish Development
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Authors: Minoux, M., & Rijli, F. M.
Affiliations: Friedrich Miescher Institute (CH)
ORCID: Minoux, Maryline
Rijli, Filippo M.
Venue: Development
Publisher: The Company of Biologists
Published: 2010-08-15
Volume: 137
Issue: 16
Pages: 2605-2621
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.040048
OpenAlex: W1980958926
Cited by: 507
References: 224
Citations by year: 2026: 37 · 2025: 26 · 2024: 29 · 2023: 28 · 2022: 26 · 2021: 44 · 2020: 33 · 2019: 41 · 2018: 32 · 2017: 36 · 2016: 29 · 2015: 31 · 2014: 33 · 2013: 30 · 2012: 33
FWCI: 2.27
Type: journal article
Language: en
Open access: closed
Locations: Development (publishedVersion)
PubMed (publishedVersion)
Funders: Novartis Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Craniofacial Disorders and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Cleft Lip and Palate Research
Keywords: cranial neural crest cells, neural crest migration, craniofacial development, skeletal morphogenesis, craniofacial evolution
MeSH terms: Animals, Cell Movement, Head, Humans, Neural Crest, Signal Transduction, Gene Expression Regulation, Developmental, Body Patterning

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Molecular mechanisms of cranial neural crest cell migration and patterning in craniofacial development

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