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A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.
Open accessAbstract
BMP-7/OP-1, a member of the transforming growth factor-beta (TGF-beta) family of secreted growth factors, is expressed during mouse embryogenesis in a pattern suggesting potential roles in a variety of inductive tissue interactions. The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye. Surprisingly, the early inductive tissue interactions responsible for establishing both organs appear largely unaffected. However, the absence of BMP-7 disrupts the subsequent cellular interactions required for their continued growth and development. Consequently, homozygous mutant animals exhibit renal dysplasia and anophthalmia at birth. Overall, these findings identify BMP-7 as an essential signaling molecule during mammalian kidney and eye development.
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Cited by
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New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099
Self-citationBone morphogenetic proteins: a critical review
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Metadata
- Authors
- Dudley, A. T., Lyons, K. M., & Robertson, E. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1995-11-15
- Volume
- 9
- Issue
- 22
- Pages
- 2795-2807
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2114245705
- Cited by
- 1,131
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Dudley, A. T., Lyons, K. M., & Robertson, E. J. (1995). A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes & Development. https://doi.org/10.1101/gad.9.22.2795
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