The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
COUP-TFI: an intrinsic factor for early regionalization of the neocortex
Open accessAbstract
Regionalization of the cerebral cortex is thought to involve two phases: an early regionalization phase and a later refinement phase. It has been shown that early regionalization of the neocortex does not require thalamic inputs and is regulated by intrinsic factors. Recently, two such intrinsic factors, Pax6 and Emx2, have been identified. In this study, we identified COUP-TFI as a regulatory factor for early neocortical regionalization. The spatial and temporal expression pattern of COUP-TFI suggested a role in specification of the neocortex and in maintaining cortical identity. Altered region-specific expression of marker genes in the cortex as well as miswired area-specific connections between the cortex and the thalamus in COUP-TFI null mice indicate COUP-TFI plays a critical role in regulating early regionalization. Our results substantiate that COUP-TFI, an intrinsic factor, may work in concert with Pax6 and Emx2 to specify neocortical identity.
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Cites
Specification of Cerebral Cortical Areas
Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127 · cited 2×
“Two popular hypotheses have been proposed: the protomap hypothesis, which emphasizes genetic influences, proposes that cortical neurons are prespecified when they are born in the ventricular zone (Rakic 1988); in contrast, the protocortex hypothesis favors the role of epigenetic factors, mainly thalamocortical innerva…”
BackgroundDo cortical areas emerge from a protocortex?
O'Leary, D. D. M. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90080-5 · Cited by 536
Cited by
Eiraku, M., Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K., & Sasai, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.002 · Cited by 1,522
Molecular logic of neocortical projection neuron specification, development and diversity
Greig, L. C., Woodworth, M. B., Galazo, M. J., Padmanabhan, H., & Macklis, J. D. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3586 · Cited by 863
Patterning and plasticity of the cerebral cortex
Sur, M., & Rubenstein, J. L. R. (2005) · Science · doi:10.1126/science.1112070 · Cited by 677
Cell-cycle control and cortical development
Dehay, C., & Kennedy, H. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2097 · Cited by 655
Nuclear receptors — a perspective from Drosophila
King-Jones, K., & Thummel, C. S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1581 · Cited by 586
Metadata
- Authors
- Zhou, C., Tsai, S. Y., & Tsai, M.-J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-08-15
- Volume
- 15
- Issue
- 16
- Pages
- 2054-2059
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2118069096
- Cited by
- 184
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Zhou, C., Tsai, S. Y., & Tsai, M.-J. (2001). COUP-TFI: an intrinsic factor for early regionalization of the neocortex. Genes & Development. https://doi.org/10.1101/gad.913601
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