The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Nuclear lamins: building blocks of nuclear architecture
Open accessAbstract
Nuclear lamins were initially identified as the major components of the nuclear lamina, a proteinaceous layer found at the interface between chromatin and the inner nuclear membrane (Fawcett 1966). Due to their position at the periphery of the nucleus, lamins were originally proposed to support the nuclear envelope and provide anchorage sites for chromatin. Recently, the nuclear lamins have also been found in the nucleoplasm (Fig. 1). In addition, experimental and genetic evidence suggest that nuclear lamins are involved in a number of other functions including nuclear envelope assembly, DNA synthesis, transcription, and apoptosis. Interestingly, mutations in nuclear lamins have been linked to human diseases. In this review, we describe what is known of the structure and function of lamins and their associated proteins. Further, we speculate about possible mechanisms through which mutations in nuclear lamins give rise to disease. Immunological and structural data originally suggested that the lamins were related to cytoplasmic intermediate filaments (IF) (Aebi et al. 1986; Goldman et al. 1986). The cloning and sequencing of lamin cDNAs confirmed that lamins have the typical domain structure of IF including an -helical coiled-coil domain flanked by nonhelical domains (Fisher et al. 1986; McKeon et al. 1986). Interestingly, analyses of lamin and cytoplasmic IF genomic sequences indicate that nuclear lamins are the progenitors of all IF, with cytoplasmic IF arising through gene duplication (Riemer et al. 2000).
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Cites
Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
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Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy
Bonne, G., Barletta, M. R. D., Varnous, S., Bécane, H.-M., Hammouda, E.-H., Merlini, L., Muntoni, F., Greenberg, C. R., Gary, F., Urtizberea, J.-A., et al. (1999) · Nature Genetics · doi:10.1038/6799 · Cited by 1,358
Loss of a-Type Lamin Expression Compromises Nuclear Envelope Integrity Leading to Muscular Dystrophy
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Slee, E. A., Adrain, C., & Martin, S. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008363200 · Cited by 1,115
The nuclear lamina is a meshwork of intermediate-type filaments
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Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy
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Nuclear Lamins: Their Structure, Assembly, and Interactions
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Cited by
Roux, K. J., Kim, D. I., Raida, M., & Burke, B. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201112098 · Cited by 2,416
Goldman, R. D., Shumaker, D. K., Erdos, M. R., Eriksson, M., Goldman, A. E., Gordon, L. B., Gruenbaum, Y., Khuon, S., Mendez, M., Varga, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402943101 · Cited by 1,103
Self-citationLamin B1 loss is a senescence-associated biomarker
Freund, A., Laberge, R.-M., Demaria, M., & Campisi, J. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0884 · Cited by 1,046
Dechat, T., Pfleghaar, K., Sengupta, K., Shimi, T., Shumaker, D. K., Solimando, L., & Goldman, R. D. (2008) · Genes & Development · doi:10.1101/gad.1652708 · Cited by 940
Self-citationMutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
Shumaker, D. K., Dechat, T., Kohlmaier, A., Adam, S. A., Bozovsky, M. R., Erdos, M. R., Eriksson, M., Goldman, A. E., Khuon, S., Collins, F. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602569103 · Cited by 791
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Metadata
- Authors
- Goldman, R. D., Gruenbaum, Y., Moir, R. D., Shumaker, D. K., & Spann, T. P.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-03-01
- Volume
- 16
- Issue
- 5
- Pages
- 533-547
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2142939796
- Cited by
- 586
- References
- 130
- Type
- posted content
- Language
- en
- Open access
- diamond
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