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Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

Dechat, Thomas, Pfleghaar, Katrin, Sengupta, Kaushik, Shimi, Takeshi, Shumaker, Dale K., Solimando, Liliana, Goldman, Robert D.·2008·Genes & Development
DOI 10.1101/gad.1652708
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Abstract

Over the past few years it has become evident that the intermediate filament proteins, the types A and B nuclear lamins, not only provide a structural framework for the nucleus, but are also essential for many aspects of normal nuclear function. Insights into lamin-related functions have been derived from studies of the remarkably large number of disease-causing mutations in the human lamin A gene. This review provides an up-to-date overview of the functions of nuclear lamins, emphasizing their roles in epigenetics, chromatin organization, DNA replication, transcription, and DNA repair. In addition, we discuss recent evidence supporting the importance of lamins in viral infections.

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Metadata

Authors
Dechat, T., Pfleghaar, K., Sengupta, K., Shimi, T., Shumaker, D. K., Solimando, L., & Goldman, R. D.
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
2008-04-01
Volume
22
Issue
7
Pages
832-853
ISSN
  • 0890-9369
  • 1549-5477
DOI
10.1101/gad.1652708
Cited by
940
References
9
Language
en

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