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Differentiation of embryonic stem cells is induced by GATA factors
Open accessAbstract
Extraembryonic endoderm (ExE) is differentiated from the inner cell mass of the late blastocyst-stage embryo to form visceral and parietal endoderm, both of which have an important role in early embryogenesis. The essential roles of Gata-6 and Gata-4 on differentiation of visceral endoderm have been identified by analyses of knockout mice. Here we report that forced expression of either Gata-6 or Gata-4 in embryonic stem (ES) cells is sufficient to induce the proper differentiation program towards ExE. We believe that this is the first report of a physiological differentiation event induced by the ectopic expression of a transcription factor in ES cells.
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Cited by
Chazaud, C., Yamanaka, Y., Pawson, T., & Rossant, J. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.02.020 · Cited by 898
Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
Arnold, S. J., & Robertson, E. J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2618 · Cited by 816
Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells
Yasunaga, M., Tada, S., Torikai-Nishikawa, S., Nakano, Y., Okada, M., Jakt, L. M., Nishikawa, S., Chiba, T., Era, T., & Nishikawa, S.-I. (2005) · Nature Biotechnology · doi:10.1038/nbt1167 · Cited by 471
Kang, M., Piliszek, A., Artus, J., & Hadjantonakis, A.-K. (2013) · Development · doi:10.1242/dev.084996 · Cited by 284
GATA6 Levels Modulate Primitive Endoderm Cell Fate Choice and Timing in the Mouse Blastocyst
Schrode, N., Saiz, N., Di Talia, S., & Hadjantonakis, A.-K. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.04.011 · Cited by 238
Metadata
- Authors
- Fujikura, J., Yamato, E., Yonemura, S., Hosoda, K., Masui, S., Nakao, K., Miyazaki, J.-I., & Niwa, H.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-04-01
- Volume
- 16
- Issue
- 7
- Pages
- 784-789
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2129957319
- Cited by
- 530
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Fujikura, J., Yamato, E., Yonemura, S., Hosoda, K., Masui, S., Nakao, K., Miyazaki, J.-I., & Niwa, H. (2002). Differentiation of embryonic stem cells is induced by GATA factors. Genes & Development. https://doi.org/10.1101/gad.968802
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
