The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis
Open accessAbstract
Pax-3 is a transcription factor that is expressed in the neural tube, neural crest, and dermomyotome. We previously showed that apoptosis is associated with neural tube defects (NTDs) in Pax-3-deficient Splotch ( Sp/Sp ) embryos. Here we show that p53 deficiency, caused by germ-line mutation or by pifithrin-α, an inhibitor of p53-dependent apoptosis, rescues not only apoptosis, but also NTDs, in Sp/Sp embryos. Pax-3 deficiency had no effect on p53 mRNA, but increased p53 protein levels. These results suggest that Pax-3 regulates neural tube closure by inhibiting p53-dependent apoptosis, rather than by inducing neural tube-specific gene expression.
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Cites
A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy
Komarov, P. G., Komarova, E. A., Kondratov, R. V., Christov-Tselkov, K., Coon, J. S., Chernov, M. V., & Gudkov, A. V. (1999) · Science · doi:10.1126/science.285.5434.1733 · Cited by 1,270
Dual Inactivation of RB and p53 Pathways in RAS-Induced Melanomas
Bardeesy, N., Bastian, B. C., Hezel, A., Pinkel, D., DePinho, R. A., & Chin, L. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.6.2144-2153.2001 · Cited by 166
Cited by
The genetic basis of mammalian neurulation
Copp, A. J., Greene, N. D. E., & Murdoch, J. N. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1181 · Cited by 697
Buckingham, M., & Relaix, F. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123438 · Cited by 484
Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function
Jones, N. C., Lynn, M. L., Gaudenz, K., Sakai, D., Aoto, K., Rey, J.-P., Glynn, E. F., Ellington, L., Du, C., Dixon, J., et al. (2008) · Nature Medicine · doi:10.1038/nm1725 · Cited by 428
Met acts on Mdm2 via mTOR to signal cell survival during development
Moumen, A., Patané, S., Porras, A., Dono, R., & Maina, F. (2007) · Development · doi:10.1242/dev.02820 · Cited by 95
Scaramozza, A., Park, D., Kollu, S., Beerman, I., Sun, X., Rossi, D. J., Lin, C. P., Scadden, D. T., Crist, C., & Brack, A. S. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.03.020 · Cited by 93
Metadata
- Authors
- Pani, L., Horal, M., & Loeken, M. R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-03-15
- Volume
- 16
- Issue
- 6
- Pages
- 676-680
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1988769766
- Cited by
- 197
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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