The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Global diversity in the human salivary microbiome
Open accessAbstract
The human salivary microbiome may play a role in diseases of the oral cavity and interact with microbiomes from other parts of the human body (in particular, the intestinal tract), but little is known about normal variation in the salivary microbiome. We analyzed 14,115 partial (∼500 bp) 16S ribosomal RNA (rRNA) sequences from saliva samples from 120 healthy individuals (10 individuals from each of 12 worldwide locations). These sequences could be assigned to 101 known bacterial genera, of which 39 were not previously reported from the human oral cavity; phylogenetic analysis suggests that an additional 64 unknown genera are present. There is high diversity in the salivary microbiome within and between individuals, but little geographic structure. Overall, ∼13.5% of the total variance in the composition of genera is due to differences among individuals, which is remarkably similar to the fraction of the total variance in neutral genetic markers that can be attributed to differences among human populations. Investigation of some environmental variables revealed a significant association between the genetic distances among locations and the distance of each location from the equator. Further characterization of the enormous diversity revealed here in the human salivary microbiome will aid in elucidating the role it plays in human health and disease, and in the identification of potentially informative species for studies of human population history.
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Cited by
The impact of the gut microbiota on human health: an integrative view
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Bacterial Community Variation in Human Body Habitats Across Space and Time
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The oral microbiome in health and disease
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Defining the healthy “core microbiome” of oral microbial communities
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Human oral, gut, and plaque microbiota in patients with atherosclerosis
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Metadata
- Authors
- Nasidze, I., Li, J., Quinque, D., Tang, K., & Stoneking, M.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-02-27
- Volume
- 19
- Issue
- 4
- Pages
- 636-643
- ISSN
- 1088-9051 (ISSN-L)
- OpenAlex
- W1998490921
- Cited by
- 466
- References
- 4
- Type
- posted content
- Language
- en
- Open access
- bronze
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