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Circos: An information aesthetic for comparative genomics

Open access
Krzywinski, Martin, Schein, Jacqueline, Birol, İnanç, Connors, Joseph, Gascoyne, Randy, Horsman, Doug, Jones, Steven J., Marra, Marco A.·2009·Genome Research

Abstract

We created a visualization tool called Circos to facilitate the identification and analysis of similarities and differences arising from comparisons of genomes. Our tool is effective in displaying variation in genome structure and, generally, any other kind of positional relationships between genomic intervals. Such data are routinely produced by sequence alignments, hybridization arrays, genome mapping, and genotyping studies. Circos uses a circular ideogram layout to facilitate the display of relationships between pairs of positions by the use of ribbons, which encode the position, size, and orientation of related genomic elements. Circos is capable of displaying data as scatter, line, and histogram plots, heat maps, tiles, connectors, and text. Bitmap or vector images can be created from GFF-style data inputs and hierarchical configuration files, which can be easily generated by automated tools, making Circos suitable for rapid deployment in data analysis and reporting pipelines.

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Metadata

Authors
Krzywinski, M., Schein, J., Birol, İ., Connors, J., Gascoyne, R., Horsman, D., Jones, S. J., & Marra, M. A.
Venue
Genome Research
Published
2009-06-18
Volume
19
Issue
9
Pages
1639-1645
ISSN
1088-9051 (ISSN-L)
OpenAlex
W2158804744
Cited by
10,964
References
2
Type
posted content
Language
en
Open access
bronze

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