The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Human and Mouse Gene Structure: Comparative Analysis and Application to Exon Prediction
Open accessAbstract
We describe a novel analytical approach to gene recognition based on cross-species comparison. We first undertook a comparison of orthologous genomic loci from human and mouse, studying the extent of similarity in the number, size and sequence of exons and introns. We then developed an approach for recognizing genes within such orthologous regions by first aligning the regions using an iterative global alignment system and then identifying genes based on conservation of exonic features at aligned positions in both species. The alignment and gene recognition are performed by new programs called GLASS and ROSETTA, respectively.ROSETTA performed well at exact identification of coding exons in 117 orthologous pairs tested.
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Citations
Cites
Needleman, S. B., & Wunsch, C. D. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90057-4 · Cited by 11,288
Cited by
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
Mauve: Multiple alignment of conserved genomic sequence with rearrangements
Darling, A. C. E., Mau, B., Blattner, F. R., & Perna, N. T. (2004) · Genome Research · doi:10.1101/gr.2289704 · Cited by 4,949
AUGUSTUS: ab initio prediction of alternative transcripts
Stanke, M., Keller, O., Gunduz, I., Hayes, A., Waack, S., & Morgenstern, B. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl200 · Cited by 2,829
GMAP: A genomic mapping and alignment program for mRNA and EST sequences
Wu, T. D., & Watanabe, C. K. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti310 · Cited by 2,354
LAGAN and Multi-LAGAN: Efficient tools for large-scale multiple alignment of genomic DNA
Brudno, M., Do, C. B., Cooper, G. M., Kim, M. F., Davydov, E., Program, N. C. S., Green, E. D., Sidow, A., & Batzoglou, S. (2003) · Genome Research · doi:10.1101/gr.926603 · Cited by 1,115
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Metadata
- Authors
- Batzoglou, S., Pachter, L., Mesirov, J. P., Berger, B., & Lander, E. S.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-07-01
- Volume
- 10
- Issue
- 7
- Pages
- 950-958
- ISSN
- 1088-9051 (ISSN-L)
- 1549-5469
- OpenAlex
- W2116688916
- Cited by
- 378
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Batzoglou, S., Pachter, L., Mesirov, J. P., Berger, B., & Lander, E. S. (2000). Human and Mouse Gene Structure: Comparative Analysis and Application to Exon Prediction. Genome Research. https://doi.org/10.1101/gr.10.7.950
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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