The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer
Open accessAbstract
The functional roles of SNPs within the 8q24 gene desert in the cancer phenotype are not yet well understood. Here, we report that CCAT2, a novel long noncoding RNA transcript (lncRNA) encompassing the rs6983267 SNP, is highly overexpressed in microsatellite-stable colorectal cancer and promotes tumor growth, metastasis, and chromosomal instability. We demonstrate that MYC, miR–17–5p, and miR–20a are up-regulated by CCAT2 through TCF7L2-mediated transcriptional regulation. We further identify the physical interaction between CCAT2 and TCF7L2 resulting in an enhancement of WNT signaling activity. We show that CCAT2 is itself a WNT downstream target, which suggests the existence of a feedback loop. Finally, we demonstrate that the SNP status affects CCAT2 expression and the risk allele G produces more CCAT2 transcript. Our results support a new mechanism of MYC and WNT regulation by the novel lncRNA CCAT2 in colorectal cancer pathogenesis, and provide an alternative explanation of the SNP-conferred cancer risk.
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Self-citationThe 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer
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Cited by
Gene regulation by long non-coding RNAs and its biological functions
Statello, L., Guo, C.-J., Chen, L.-L., & Huarte, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00315-9 · Cited by 4,991
The emerging role of lncRNAs in cancer
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The role of non-coding RNAs in oncology
Slack, F. J., & Chinnaiyan, A. M. (2019) · Cell · doi:10.1016/j.cell.2019.10.017 · Cited by 1,619
Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer
Mármol, I., Sánchez-de-Diego, C., Pradilla Dieste, A., Cerrada, E., & Rodriguez Yoldi, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010197 · Cited by 1,525
Long noncoding RNAs in cancer: mechanisms of action and technological advancements
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Metadata
- Authors
- Ling, H., Spizzo, R., Atlasi, Y., Nicoloso, M., Shimizu, M., Redis, R. S., Nishida, N., Gafà, R., Song, J., Guo, Z., Ivan, C., Barbarotto, E., De Vries, I., Zhang, X., Ferracin, M., Churchman, M., van Galen, J. F., Beverloo, B. H., Shariati, M., Haderk, F., Estecio, M. R., Garcia-Manero, G., Patijn, G. A., Gotley, D. C., Bhardwaj, V., Shureiqi, I., Sen, S., Multani, A. S., Welsh, J., Yamamoto, K., Taniguchi, I., Song, M.-A., Gallinger, S., Casey, G., Thibodeau, S. N., Le Marchand, L., Tiirikainen, M., Mani, S. A., Zhang, W., Davuluri, R. V., Mimori, K., Mori, M., Sieuwerts, A. M., Martens, J. W. M., Tomlinson, I., Negrini, M., Berindan-Neagoe, I., Foekens, J. A., Hamilton, S. R., Lanza, G., Kopetz, S., Fodde, R., & Calin, G. A.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-06-24
- Volume
- 23
- Issue
- 9
- Pages
- 1446-1461
- ISSN
- 1088-9051 (ISSN-L)
- OpenAlex
- W2003870059
- Cited by
- 602
- References
- 9
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Ling, H., Spizzo, R., Atlasi, Y., Nicoloso, M., Shimizu, M., Redis, R. S., Nishida, N., Gafà, R., Song, J., Guo, Z., Ivan, C., Barbarotto, E., De Vries, I., Zhang, X., Ferracin, M., Churchman, M., van Galen, J. F., Beverloo, B. H., Shariati, M., . . . Calin, G. A. (2013). CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Research. https://doi.org/10.1101/gr.152942.112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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