The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Fourfold Faster Rate of Genome Rearrangement in Nematodes Than in Drosophila
Open accessAbstract
We compared the genome of the nematode Caenorhabditis elegans to 13% of that of Caenorhabditis briggsae, identifying 252 conserved segments along their chromosomes. We detected 517 chromosomal rearrangements, with the ratio of translocations to inversions to transpositions being ∼1:1:2. We estimate that the species diverged 50–120 million years ago, and that since then there have been 4030 rearrangements between their whole genomes. Our estimate of the rearrangement rate, 0.4–1.0 chromosomal breakages/Mb per Myr, is at least four times that of Drosophila, which was previously reported to be the fastest rate among eukaryotes. The breakpoints of translocations are strongly associated with dispersed repeats and gene family members in the C. elegans genome. [The following institution kindly provided reagents, samples or unpublished information as indicated in the paper: Genome Sequencing Center, Washington University School of Medicine, St. Louis.]
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Improved tools for biological sequence comparison.
Pearson, W. R., & Lipman, D. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2444 · Cited by 11,227
Evidence for a clade of nematodes, arthropods and other moulting animals
Aguinaldo, A. M. A., Turbeville, J. M., Linford, L. S., Rivera, M. C., Garey, J. R., Raff, R. A., & Lake, J. A. (1997) · Nature · doi:10.1038/387489a0 · Cited by 1,609
Effective deme sizes during long-term evolution estimated from rates of chromosomal rearrangement
Lande, R. (1979) · Evolution · doi:10.1111/j.1558-5646.1979.tb04678.x · Cited by 792
Wang, D. Y.-C., Kumar, S., & Hedges, S. B. (1999) · Proceedings of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rspb.1999.0617 · Cited by 493 · cited 1×
“Although the exact branching order of the chordates, arthropods, and nematodes continues to be hotly debated (Mushegian et al. 1998; Wang et al. 1999), most estimates of the divergence of these three phyla range from 800 to 1000 Mya (Blaxter 1998; Brooke 1999).”
BackgroundMushegian, A. R., Garey, J. R., Martin, J., & Liu, L. X. (1998) · Genome Research · doi:10.1101/gr.8.6.590 · Cited by 164 · cited 5×
“Although the exact branching order of the chordates, arthropods, and nematodes continues to be hotly debated (Mushegian et al. 1998; Wang et al. 1999), most estimates of the divergence of these three phyla range from 800 to 1000 Mya (Blaxter 1998; Brooke 1999).”
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Large-Scale Sequencing Reveals 21U-RNAs and Additional MicroRNAs and Endogenous siRNAs in C. elegans
Ruby, J. G., Jan, C., Player, C., Axtell, M. J., Lee, W., Nusbaum, C., Ge, H., & Bartel, D. P. (2006) · Cell · doi:10.1016/j.cell.2006.10.040 · Cited by 983
The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics
Stein, L. D., Bao, Z., Blasiar, D., Blumenthal, T., Brent, M. R., Chen, N., Chinwalla, A., Clarke, L., Clee, C., Coghlan, A., et al. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000045 · Cited by 940
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Metadata
- Authors
- Coghlan, A., & Wolfe, K. H.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-06-01
- Volume
- 12
- Issue
- 6
- Pages
- 857-867
- ISSN
- 1088-9051 (ISSN-L)
- 1549-5469
- OpenAlex
- W2104106326
- Cited by
- 211
- References
- 5
- Type
- posted content
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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