Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome

Kahlem, Pascal, Sultan, Marc, Herwig, Ralf, Steinfath, Matthias, Balzereit, Daniela, Eppens, Barbara, Saran, Nidhi G., Pletcher, Mathew T. +5 more·2004·Genome Research

Cited by (249)

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  8. Gene-Dosage Effect on Chromosome 21 Transcriptome in Trisomy 21: Implication in Down Syndrome Cognitive Disorders
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  11. CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation
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  16. Complex contributions of Ets2 to craniofacial and thymus phenotypes of trisomic “Down syndrome” mice
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  17. Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome
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  18. The developmental transcriptome landscape of bovine skeletal muscle defined by Ribo-Zero ribonucleic acid sequencing1
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  19. Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome
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  20. The App-Runx1 Region Is Critical for Birth Defects and Electrocardiographic Dysfunctions Observed in a Down Syndrome Mouse Model
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  21. Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics
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  26. Genome-Wide Expression Analysis in Down Syndrome: Insight into Immunodeficiency
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  27. Genomic determinants in the phenotypic variability of Down syndrome
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  29. Integrative multi-omic analysis reveals conserved cell-projection deficits in human Down syndrome brains
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  32. Alterations of brain circuits in Down syndrome murine models
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  33. Maternal choline supplementation protects against age-associated cholinergic and GABAergic basal forebrain neuron degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease
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  34. A quantitative assessment of gene expression (QAGE) reveals differential overexpression of DOPEY2, a candidate gene for mental retardation, in Down syndrome brain regions
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  38. Down syndrome in Estonia
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  41. Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome
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  47. 4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates
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