Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome
Kahlem, Pascal, Sultan, Marc, Herwig, Ralf, Steinfath, Matthias, Balzereit, Daniela, Eppens, Barbara, Saran, Nidhi G., Pletcher, Mathew T. +5 more·2004·Genome Research
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- Down Syndrome: A Complex and Interactive Genetic DisorderL. Samantha, Joshua D., Philip D. Jeffrey, Randall J. · 2011 · InTech eBooks
- Morphology of early intrauterine deaths with full trisomy 15Tom Philipp, Jefferson Terry, Michael Feichtinger, Sandra Grillenberger, Beda W. Hartmann, Stefan Jirecek · 2018 · Prenatal Diagnosis
- Detection and functional annotation of misregulated microRNAs in the brain of the Ts65Dn mouse model of Down syndromeXijing He, Yun Xiao, Qi Zhang, Liping Ma, Na Li, Jing Yang · 2013 · Chinese Medical Journal
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- Comprehensive behavioral assays to enhance phenotype to genotype linkages and therapeutic screening in mouse models of Down syndromeMehrdad Shamloo, Pavel V. Belichenko, William Cary Mobley · 2010 · Future Neurology
- Evaluation of reference genes for gene expression in red-tailed phascogale ( Phascogale calura ) liver, lung, small intestine and spleenOselyne T. W. Ong, Lauren J. Young, Julie M. Old · 2016 · PeerJ
- Détection de la trisomie 21 par l’étude de l’ADNP. Bouizegarène, Najim Ameziane, M. Bogard, Jean‐Charles Deybach, J. Lamoril · 2008 · Immuno-analyse & Biologie Spécialisée
- Identification of a thymus microRNA‑mRNA regulatory network in Down syndromeMiao Chai, Liju Su, Xiaolei Hao, Meng Zhang, Lihui Zheng, Jiabing Bi, Xiao Han, Chunbo Gao · 2019 · Molecular Medicine Reports
- The hominoid-specific gene DSCR4 is involved in regulation of human leukocyte migrationMorteza Mahmoudi Saber, Marziyeh Karimiavargani, Nilmini Hettiarachchi, Michiaki Hamada, Takanori Uzawa, Yoshihiro Ito, Naruya Saitou · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
- Impact of Chromosomal Instability and Aneuploidy in Cancer DevelopmentAmanda K. Mennie, Brittiny Dhital, Peter Ly · 2025 · Annual Review of Cancer Biology
- Skeletal Muscle Function, Morphology, and Biochemistry in Ts65Dn Mice: A Model of Down SyndromePatrick M. Cowley · 2011 · Syracuse University Libraries (Syracuse University)
- No Evidence for Mutations that Deregulate GARS–AIRS–GART Protein Levels in Children with Down SyndromeDisha Banerjee, Debarati Ghosh, Anindita Chatterjee, Swagata Sinha, Krishnadas Nandagopal · 2012 · Indian Journal of Clinical Biochemistry
- Identification of Molecules with Altered Expression in the Brain of Mouse Model for Down Syndrome by Comprehensive AnalysesKeiichi Ishihara · 2013 · YAKUGAKU ZASSHI
- How does a 1.5-Fold Increase in Gene Dosage in Chromosome 21 Causes the Pleiotropic Phenotypes in Down Syndrome?Baojin Ding · 2015 · Journal of Down Syndrome & Chromosome Abnormalities
- Epigenetics and Down syndromeAlain D. Dekker, P.P. De Deyn, Marianne G. Rots · 2016 · Elsevier eBooks
- The Genetic Dosage Imbalance Linked to Clinical Brain Alterations and Mental Disability in Down Syndrome Could be Targeted for Therapeutics DevelopmentMohammed Rachidi · 2018 · Medical Journal of Clinical Trials & Case Studies
- Down SyndromeAaron B. Bowman, Kevin C. Ess, Kevin K. Kumar, Karen L. Summar · 2013 · Elsevier eBooks
- Detection of Copy Number Alterations Using Single Cell SequencingKristin A. Knouse, Jie Wu, Austin Hendricks · 2017 · Journal of Visualized Experiments
- The accumulation of copper in the brain of Down syndrome promotes oxidative stress: possible mechanism underlying cognitive impairmentKeiichi Ishihara · 2022 · Journal of Clinical Biochemistry and Nutrition
- Integrated Quantitative Neuro-Transcriptome Analysis of Several Brain Areas in Human Trisomy 21Alejandra Rodríguez-Ortiz, Julio César Montoya-Villegas, Felipe García‐Vallejo, Yecid Mina-Paz · 2022 · Genes
- Down Syndrome: Clinical and Genetic Aspects, Genetic Counseling and Prenatal Screening and DiagnosisÉrika Cristina Pavarino, Joice Matos, Walter Pinto, Eny Maria Goloni‐Bertollo · 2013 · InTech eBooks
- Complex networks of interaction of genes located in the critical region of Down syndrome expressed in the normal human brainDianora Fajardo, Karla Vinasco, Julio César Montoya, Jose M Satizabal, Adalberto Sánchez, Felipe García‐Vallejo · 2018 · Biomedical Research - India
- Time and space dimensions of gene dosage imbalance of aneuploidies revealed by single cell transcriptomesGeorgios Stamoulis, Marco Garieri, Periklis Makrythanasis, Audrey Letourneau, Michel Guipponi, Nikolaos I. Panousis, Frederique Sloan Bena, Emilie Falconnet, Pascale Ribaux, Christelle Borel et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
- Idendification de gènes à effet de dose impliqués dans la pathophysiologie des aneuploïdies associées au chromosome 21Emilie Dalloneau · 2010
- L'insertion professionnelle d'adultes porteurs de trisomie 21 : liens entre profils cognitifs, contexte de vie, autonomie et qualité de vieLise Lemoine · 2010
- Maladies chromosomiques constitutionnelles : corrélations génotype-phénotypeCarole Goumy · 2009 · HAL
- Analyse von Biochips: Von der Sequenz zum SystemRalf Herwig, Johannes Schuchhardt, Luckas Chavez, Hans Rudolf Lehrach · 2008 · Springer eBooks
- Differential protein expression in normal and trisomic cell lines from murine cerebral cortex measured by itraq and Mass SpectrometryLeigh E. Wicki‐Stordeur, Nesreen Al Faresi, Ahmed M. Almehdi, DEREK S. H. SMITH, Christoph H. Borchers, Terry W. Pearson, Jody D. Haddow · 2012 · Mediterranean Journal of Chemistry
- Social dysfunction and mental retardationSusanna Pietropaolo, Frans Sluyter, Wim E. Crusio · 2014 · Cambridge University Press eBooks
- Human Genome & Diseases: Review Aneuploidy in the normal and diseased brainMarcy A. Kingsbury, Yun C. Yung, Suzanne E. Peterson, Jurjen W. Westra, Jerold J. M. Chun, Helen L. Dorris · 2006
- Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for TherapeuticsUnitde Biologie Fonctionnelle · 2012
- Overexpression of Amyloid Precursor Protein Induces Mitochondrial Oxidative Stress and Activates the Intrinsic Apoptosis PathwayMatthew G. Bartley · 2010 · Digital Commons - DU (University of Denver)
- Improving Verification and Validation Process of Autonomic Systems with the Help of System Performance Feedback and Stochastic Optimal ControlSam B. Adhikari · 2012 · AIAA Infotech@Aerospace Conference
- Down syndromeMara Dierssen · 2014 · Cambridge University Press eBooks
- Characterisation of glyoxalase 1 mutant mouse and glyoxalase 1 copy number alterationAlaa Shafie · 2026 · Warwick Research Archive Portal (University of Warwick)
- EFFECTS OF HSA21 GENE EXPRESSION ON EARLY VERTEBRATE DEVELOPMENTSarah Edie · 2014
- Placental Expression of the Forelimb Patterning Transcription Factor MEIS2 in Trisomy 15Jennifer Pors, Tom Philipp, Jefferson Terry · 2020 · Fetal and Pediatric Pathology
- SKELETAL DEFICITS IN MALE AND FEMALE MOUSE MODELS OF DOWN SYNDROMEJared R. Thomas · 2020 · Purdue e-Pubs (Purdue University System)
- A New Approach to The Pathogenesis of Down Syndrome: An Integrated Quantitative Neuro-Transcriptome Analysis of Several Brain Areas in Human Trisomy 21.Alejandra Rodríguez-Ortiz, Julio César Montoya Villegas, Adalberto Sánchez, José María Satizábal Soto, Yecid Mina-Paz, Felipe García‐Vallejo · 2021 · Research Square
- ConclusionDavid Rasnick · 2012 · CRC Press eBooks
- The cognitive phenotype of Down syndrome: Insights from intracellular network analysisAvi Ma’ayan, Katheleen Gardiner, Ravi Iyengar · 2006 · Neurotherapeutics
- Dual‐Specificity Tyrosine Phosphorylation‐Regulated Kinase‐1A (DYRK1A), A Master Regulatory Protein Involved in Down Syndrome Brain Alterations and Mental Disability, A Key Contributor to Neurodegenerative Disorders of Alzheimer's Disease and A Potential Therapeutic TargetMohammed Rachidi · 2022 · International Journal of Neurodegenerative Disorders
- Gene-dosage imbalance due to trisomic HSA21 and genotype–phenotype association in Down syndromeBani Bandana Ganguly · 2022 · Elsevier eBooks
- Physical Training Chronically Stimulates the Motor Neuron Cell Nucleus in the Ts65Dn Mouse, a Model of Down SyndromeChiara Rita Inguscio, Maria Assunta Lacavalla, Barbara Cisterna, Carlo Zancanaro, Manuela Malatesta · 2023 · Cells
- DYRK1A (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A), a Master Regulatory Protein Involved in Down Syndrome Clinical Neurological Abnormalities and Associated Mental Retardation and a Promising Potential Drug Target for Therapeutics and TreatmentsMohammed Rachidi · 2023 · Medical Journal of Clinical Trials & Case Studies
- Etude de modèle Murin pour l'aneuploïdie de la région PRMT2 CSTB homologue au chromosome 21 humainArnaud Duchon · 2011
- Influence of centrosome amplification on the response to chemotherapy in epithelial ovarian cancerGiulia Fantozzi · 2023 · theses.fr (ABES)
- Post-daunorubicin treatment effects on cardiovascular function in the Ts65Dn mouse model of Down syndromeMichelle A. Buckman, Anastasiia Vasileva, Hardik Kalra, Immaculate Edwin, Guiru Ma, Mikhail Vasilyev, Barry London, Charles R. Jedlicka, Gary Beasley, Patrick John Breheny et al. · 2026 · Physiology