Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome

Kahlem, Pascal, Sultan, Marc, Herwig, Ralf, Steinfath, Matthias, Balzereit, Daniela, Eppens, Barbara, Saran, Nidhi G., Pletcher, Mathew T. +5 more·2004·Genome Research

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  2. Down Syndrome: A Complex and Interactive Genetic Disorder
    L. Samantha, Joshua D., Philip D. Jeffrey, Randall J. · 2011 · InTech eBooks
  3. Morphology of early intrauterine deaths with full trisomy 15
    Tom Philipp, Jefferson Terry, Michael Feichtinger, Sandra Grillenberger, Beda W. Hartmann, Stefan Jirecek · 2018 · Prenatal Diagnosis
  4. Detection and functional annotation of misregulated microRNAs in the brain of the Ts65Dn mouse model of Down syndrome
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  5. Understanding type 1 diabetes genetics - approaches for identification of susceptibility genes in multi-factorial diseases.
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  6. Comprehensive behavioral assays to enhance phenotype to genotype linkages and therapeutic screening in mouse models of Down syndrome
    Mehrdad Shamloo, Pavel V. Belichenko, William Cary Mobley · 2010 · Future Neurology
  7. Evaluation of reference genes for gene expression in red-tailed phascogale ( Phascogale calura ) liver, lung, small intestine and spleen
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  8. Détection de la trisomie 21 par l’étude de l’ADN
    P. Bouizegarène, Najim Ameziane, M. Bogard, Jean‐Charles Deybach, J. Lamoril · 2008 · Immuno-analyse & Biologie Spécialisée
  9. Identification of a thymus microRNA‑mRNA regulatory network in Down syndrome
    Miao Chai, Liju Su, Xiaolei Hao, Meng Zhang, Lihui Zheng, Jiabing Bi, Xiao Han, Chunbo Gao · 2019 · Molecular Medicine Reports
  10. The hominoid-specific gene DSCR4 is involved in regulation of human leukocyte migration
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  12. Skeletal Muscle Function, Morphology, and Biochemistry in Ts65Dn Mice: A Model of Down Syndrome
    Patrick M. Cowley · 2011 · Syracuse University Libraries (Syracuse University)
  13. No Evidence for Mutations that Deregulate GARS–AIRS–GART Protein Levels in Children with Down Syndrome
    Disha Banerjee, Debarati Ghosh, Anindita Chatterjee, Swagata Sinha, Krishnadas Nandagopal · 2012 · Indian Journal of Clinical Biochemistry
  14. Identification of Molecules with Altered Expression in the Brain of Mouse Model for Down Syndrome by Comprehensive Analyses
    Keiichi Ishihara · 2013 · YAKUGAKU ZASSHI
  15. How does a 1.5-Fold Increase in Gene Dosage in Chromosome 21 Causes the Pleiotropic Phenotypes in Down Syndrome?
    Baojin Ding · 2015 · Journal of Down Syndrome & Chromosome Abnormalities
  16. Epigenetics and Down syndrome
    Alain D. Dekker, P.P. De Deyn, Marianne G. Rots · 2016 · Elsevier eBooks
  17. The Genetic Dosage Imbalance Linked to Clinical Brain Alterations and Mental Disability in Down Syndrome Could be Targeted for Therapeutics Development
    Mohammed Rachidi · 2018 · Medical Journal of Clinical Trials & Case Studies
  18. Down Syndrome
    Aaron B. Bowman, Kevin C. Ess, Kevin K. Kumar, Karen L. Summar · 2013 · Elsevier eBooks
  19. Detection of Copy Number Alterations Using Single Cell Sequencing
    Kristin A. Knouse, Jie Wu, Austin Hendricks · 2017 · Journal of Visualized Experiments
  20. The accumulation of copper in the brain of Down syndrome promotes oxidative stress: possible mechanism underlying cognitive impairment
    Keiichi Ishihara · 2022 · Journal of Clinical Biochemistry and Nutrition
  21. Integrated Quantitative Neuro-Transcriptome Analysis of Several Brain Areas in Human Trisomy 21
    Alejandra Rodríguez-Ortiz, Julio César Montoya-Villegas, Felipe García‐Vallejo, Yecid Mina-Paz · 2022 · Genes
  22. Down Syndrome: Clinical and Genetic Aspects, Genetic Counseling and Prenatal Screening and Diagnosis
    Érika Cristina Pavarino, Joice Matos, Walter Pinto, Eny Maria Goloni‐Bertollo · 2013 · InTech eBooks
  23. Complex networks of interaction of genes located in the critical region of Down syndrome expressed in the normal human brain
    Dianora Fajardo, Karla Vinasco, Julio César Montoya, Jose M Satizabal, Adalberto Sánchez, Felipe García‐Vallejo · 2018 · Biomedical Research - India
  24. Time and space dimensions of gene dosage imbalance of aneuploidies revealed by single cell transcriptomes
    Georgios Stamoulis, Marco Garieri, Periklis Makrythanasis, Audrey Letourneau, Michel Guipponi, Nikolaos I. Panousis, Frederique Sloan Bena, Emilie Falconnet, Pascale Ribaux, Christelle Borel et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  25. Idendification de gènes à effet de dose impliqués dans la pathophysiologie des aneuploïdies associées au chromosome 21
    Emilie Dalloneau · 2010
  26. L'insertion professionnelle d'adultes porteurs de trisomie 21 : liens entre profils cognitifs, contexte de vie, autonomie et qualité de vie
    Lise Lemoine · 2010
  27. Maladies chromosomiques constitutionnelles : corrélations génotype-phénotype
    Carole Goumy · 2009 · HAL
  28. Analyse von Biochips: Von der Sequenz zum System
    Ralf Herwig, Johannes Schuchhardt, Luckas Chavez, Hans Rudolf Lehrach · 2008 · Springer eBooks
  29. Differential protein expression in normal and trisomic cell lines from murine cerebral cortex measured by itraq and Mass Spectrometry
    Leigh E. Wicki‐Stordeur, Nesreen Al Faresi, Ahmed M. Almehdi, DEREK S. H. SMITH, Christoph H. Borchers, Terry W. Pearson, Jody D. Haddow · 2012 · Mediterranean Journal of Chemistry
  30. Social dysfunction and mental retardation
    Susanna Pietropaolo, Frans Sluyter, Wim E. Crusio · 2014 · Cambridge University Press eBooks
  31. Human Genome & Diseases: Review Aneuploidy in the normal and diseased brain
    Marcy A. Kingsbury, Yun C. Yung, Suzanne E. Peterson, Jurjen W. Westra, Jerold J. M. Chun, Helen L. Dorris · 2006
  32. Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics
    Unitde Biologie Fonctionnelle · 2012
  33. Overexpression of Amyloid Precursor Protein Induces Mitochondrial Oxidative Stress and Activates the Intrinsic Apoptosis Pathway
    Matthew G. Bartley · 2010 · Digital Commons - DU (University of Denver)
  34. Improving Verification and Validation Process of Autonomic Systems with the Help of System Performance Feedback and Stochastic Optimal Control
    Sam B. Adhikari · 2012 · AIAA Infotech@Aerospace Conference
  35. Down syndrome
    Mara Dierssen · 2014 · Cambridge University Press eBooks
  36. Characterisation of glyoxalase 1 mutant mouse and glyoxalase 1 copy number alteration
    Alaa Shafie · 2026 · Warwick Research Archive Portal (University of Warwick)
  37. EFFECTS OF HSA21 GENE EXPRESSION ON EARLY VERTEBRATE DEVELOPMENT
    Sarah Edie · 2014
  38. Placental Expression of the Forelimb Patterning Transcription Factor MEIS2 in Trisomy 15
    Jennifer Pors, Tom Philipp, Jefferson Terry · 2020 · Fetal and Pediatric Pathology
  39. SKELETAL DEFICITS IN MALE AND FEMALE MOUSE MODELS OF DOWN SYNDROME
    Jared R. Thomas · 2020 · Purdue e-Pubs (Purdue University System)
  40. A New Approach to The Pathogenesis of Down Syndrome: An Integrated Quantitative Neuro-Transcriptome Analysis of Several Brain Areas in Human Trisomy 21.
    Alejandra Rodríguez-Ortiz, Julio César Montoya Villegas, Adalberto Sánchez, José María Satizábal Soto, Yecid Mina-Paz, Felipe García‐Vallejo · 2021 · Research Square
  41. Conclusion
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  42. The cognitive phenotype of Down syndrome: Insights from intracellular network analysis
    Avi Ma’ayan, Katheleen Gardiner, Ravi Iyengar · 2006 · Neurotherapeutics
  43. Dual‐Specificity Tyrosine Phosphorylation‐Regulated Kinase‐1A (DYRK1A), A Master Regulatory Protein Involved in Down Syndrome Brain Alterations and Mental Disability, A Key Contributor to Neurodegenerative Disorders of Alzheimer's Disease and A Potential Therapeutic Target
    Mohammed Rachidi · 2022 · International Journal of Neurodegenerative Disorders
  44. Gene-dosage imbalance due to trisomic HSA21 and genotype–phenotype association in Down syndrome
    Bani Bandana Ganguly · 2022 · Elsevier eBooks
  45. Physical Training Chronically Stimulates the Motor Neuron Cell Nucleus in the Ts65Dn Mouse, a Model of Down Syndrome
    Chiara Rita Inguscio, Maria Assunta Lacavalla, Barbara Cisterna, Carlo Zancanaro, Manuela Malatesta · 2023 · Cells
  46. DYRK1A (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A), a Master Regulatory Protein Involved in Down Syndrome Clinical Neurological Abnormalities and Associated Mental Retardation and a Promising Potential Drug Target for Therapeutics and Treatments
    Mohammed Rachidi · 2023 · Medical Journal of Clinical Trials & Case Studies
  47. Etude de modèle Murin pour l'aneuploïdie de la région PRMT2 CSTB homologue au chromosome 21 humain
    Arnaud Duchon · 2011
  48. Influence of centrosome amplification on the response to chemotherapy in epithelial ovarian cancer
    Giulia Fantozzi · 2023 · theses.fr (ABES)
  49. Post-daunorubicin treatment effects on cardiovascular function in the Ts65Dn mouse model of Down syndrome
    Michelle A. Buckman, Anastasiia Vasileva, Hardik Kalra, Immaculate Edwin, Guiru Ma, Mikhail Vasilyev, Barry London, Charles R. Jedlicka, Gary Beasley, Patrick John Breheny et al. · 2026 · Physiology