The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Transposons passively and actively contribute to evolution of the two-speed genome of a fungal pathogen
Open accessAbstract
Genomic plasticity enables adaptation to changing environments, which is especially relevant for pathogens that engage in “arms races” with their hosts. In many pathogens, genes mediating virulence cluster in highly variable, transposon-rich, physically distinct genomic compartments. However, understanding of the evolution of these compartments, and the role of transposons therein, remains limited. Here, we show that transposons are the major driving force for adaptive genome evolution in the fungal plant pathogen Verticillium dahliae . We show that highly variable lineage-specific (LS) regions evolved by genomic rearrangements that are mediated by erroneous double-strand repair, often utilizing transposons. We furthermore show that recent genetic duplications are enhanced in LS regions, against an older episode of duplication events. Finally, LS regions are enriched in active transposons, which contribute to local genome plasticity. Thus, we provide evidence for genome shaping by transposons, both in an active and passive manner, which impacts the evolution of pathogen virulence.
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Citations
Cites
OrthoMCL: Identification of Ortholog Groups for Eukaryotic Genomes
Li, L., Stoeckert, C. J., & Roos, D. S. (2003) · Genome Research · doi:10.1101/gr.1224503 · Cited by 5,707
Versatile and open software for comparing large genomes
Kurtz, S., Phillippy, A., Delcher, A. L., Smoot, M., Shumway, M., Antonescu, C., & Salzberg, S. L. (2004) · Genome Biology · doi:10.1186/gb-2004-5-2-r12 · Cited by 5,254
Genomic Islands in the Pathogenic Filamentous Fungus Aspergillus fumigatus
Fedorova, N. D., Khaldi, N., Joardar, V. S., Maiti, R., Amedeo, P., Anderson, M. J., Crabtree, J., Silva, J. C., Badger, J. H., Albarraq, A., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000046 · Cited by 508 · cited 2×
“embedded within the core chromosomes or reside on conditionally dispensable chromosomes (Thon et al. 2006; Fedorova et al. 2008; Haas et al. 2009; Ma et al. 2010; Goodwin et al. 2011; Klosterman et al. 2011; Rouxel et al. 2011; de Jonge et al. 2013).”
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Cited by
Liang, X., Wang, B., Dong, Q., Li, L., Rollins, J. A., Zhang, R., & Sun, G. (2018) · PLOS ONE · doi:10.1371/journal.pone.0196303 · Cited by 69
Fungal Genomes and Insights into the Evolution of the Kingdom
Stajich, J. E. (2017) · The Fungal Kingdom · doi:10.1128/9781555819583.ch29 · Cited by 22
Metadata
- Authors
- Faino, L., Seidl, M. F., Shi-Kunne, X., Pauper, M., van den Berg, G. C. M., Wittenberg, A. H. J., & Thomma, B. P. H. J.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2016-06-20
- Volume
- 26
- Issue
- 8
- Pages
- 1091-1100
- ISSN
- 1088-9051 (ISSN-L)
- 1549-5469
- OpenAlex
- W2468803195
- Cited by
- 319
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
