The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
Relaxation of selective constraint on dog mitochondrial DNA following domestication
Open accessAbstract
The domestication of dogs caused a dramatic change in their way of life compared with that of their ancestor, the gray wolf. We hypothesize that this new life style changed the selective forces that acted upon the species, which in turn had an effect on the dog's genome. We sequenced the complete mitochondrial DNA genome in 14 dogs, six wolves, and three coyotes. Here we show that dogs have accumulated nonsynonymous changes in mitochondrial genes at a faster rate than wolves, leading to elevated levels of variation in their proteins. This suggests that a major consequence of domestication in dogs was a general relaxation of selective constraint on their mitochondrial genome. If this change also affected other parts of the dog genome, it could have facilitated the generation of novel functional genetic diversity. This diversity could thus have contributed raw material upon which artificial selection has shaped modern breeds and may therefore be an important source of the extreme phenotypic variation present in modern-day dogs.
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“and the same is true of their mitochondrial DNA [130]”
From Self-domestication in Homo sapiens: Insights from comparative genomics (2017) · cites this paper as [130]
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“A build-up of deleterious alleles is documented across domesticated species when compared to their wild counterparts.”
From Self-domestication in Homo sapiens: Insights from comparative genomics (2017) · cites this paper as [130]
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1 of the 38 references couldn’t be matched to a known paper.
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- Coppinger R. Coppinger L. (2001) Dogs (The University of Chicago Press, Chicago).
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Nabholz, B., Uwimana, N., & Lartillot, N. (2013) · Data Archiving and Networked Services (DANS) · doi:10.5061/dryad.72594.1
Metadata
- Authors
- Björnerfeldt, S., Webster, M. T., & Vilà, C.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Vilà, Carles
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-06-29
- Volume
- 16
- Issue
- 8
- Pages
- 990-994
- ISSN
- 1088-9051 (ISSN-L)
- PMC
- PMC1524871
- OpenAlex
- W2097187579
- Cited by
- 203
- References
- 38
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 10 · 2023: 11 · 2022: 2 · 2021: 16 · 2020: 6 · 2019: 8 · 2018: 11 · 2017: 11 · 2016: 13 · 2015: 9 · 2014: 20 · 2013: 16 · 2012: 6
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genome Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kansas Department of Wildlife and Parks
- Svenska Forskningsrådet Formas
- Vetenskapsrådet
- Sveriges Lantbruksuniversitet
- Uppsala Universitet
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Human-Animal Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- dog domestication, mitochondrial DNA, non-synonymous mutations, relaxed selection, gray wolf, coyote, mitochondrial genome evolution, selective breeding, phenotypic variability, genetic diversity
- MeSH terms
- Animals, Animals, Domestic, DNA, Mitochondrial, Dogs, Phylogeny, Likelihood Functions
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