PreprintCited by 203Human-Animal Interaction StudiesGenetic and phenotypic traits in livestockGenetic diversity and population structure

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Relaxation of selective constraint on dog mitochondrial DNA following domestication

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Björnerfeldt, Susanne, Webster, Matthew T., Vilà, Carles·2006·Genome Research

DOI 10.1101/gr.5117706PMC PMC1524871

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Abstract

The domestication of dogs caused a dramatic change in their way of life compared with that of their ancestor, the gray wolf. We hypothesize that this new life style changed the selective forces that acted upon the species, which in turn had an effect on the dog's genome. We sequenced the complete mitochondrial DNA genome in 14 dogs, six wolves, and three coyotes. Here we show that dogs have accumulated nonsynonymous changes in mitochondrial genes at a faster rate than wolves, leading to elevated levels of variation in their proteins. This suggests that a major consequence of domestication in dogs was a general relaxation of selective constraint on their mitochondrial genome. If this change also affected other parts of the dog genome, it could have facilitated the generation of novel functional genetic diversity. This diversity could thus have contributed raw material upon which artificial selection has shaped modern breeds and may therefore be an important source of the extreme phenotypic variation present in modern-day dogs.

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Authors: Björnerfeldt, S., Webster, M. T., & Vilà, C.
Affiliations: Uppsala University (SE)
Corresponding author: Vilà, Carles
ORCID: Webster, Matthew T.
Vilà, Carles
Venue: Genome Research
Publisher: Cold Spring Harbor Laboratory
Published: 2006-06-29
Volume: 16
Issue: 8
Pages: 990-994
ISSN: 1088-9051 (ISSN-L)
DOI: 10.1101/gr.5117706
PMC: PMC1524871
OpenAlex: W2097187579
Cited by: 203
References: 38
Citations by year: 2026: 6 · 2025: 5 · 2024: 10 · 2023: 11 · 2022: 2 · 2021: 16 · 2020: 6 · 2019: 8 · 2018: 11 · 2017: 11 · 2016: 13 · 2015: 9 · 2014: 20 · 2013: 16 · 2012: 6
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genome Research (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Kansas Department of Wildlife and Parks
Svenska Forskningsrådet Formas
Vetenskapsrådet
Sveriges Lantbruksuniversitet
Uppsala Universitet
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Human-Animal Interaction Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Keywords: dog domestication, mitochondrial DNA, non-synonymous mutations, relaxed selection, gray wolf, coyote, mitochondrial genome evolution, selective breeding, phenotypic variability, genetic diversity
MeSH terms: Animals, Animals, Domestic, DNA, Mitochondrial, Dogs, Phylogeny, Likelihood Functions

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Relaxation of selective constraint on dog mitochondrial DNA following domestication

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