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Gene Expression Profiling of Embryo-Derived Stem Cells Reveals Candidate Genes Associated With Pluripotency and Lineage Specificity
Open accessAbstract
Large-scale gene expression profiling was performed on embryo-derived stem cell lines to identify molecular signatures of pluripotency and lineage specificity. Analysis of pluripotent embryonic stem (ES) cells, extraembryonic-restricted trophoblast stem (TS) cells, and terminally-differentiated mouse embryo fibroblast (MEF) cells identified expression profiles unique to each cell type, as well as genes common only to ES and TS cells. Whereas most of the MEF-specific genes had been characterized previously, the majority (67%) of the ES-specific genes were novel and did not include known differentiated cell markers. Comparison with microarray data from embryonic material demonstrated that ES-specific genes were underrepresented in all stages sampled, whereas TS-specific genes included known placental markers. Investigation of four novel TS-specific genes showed trophoblast-restricted expression in cell lines and in vivo, whereas one uncharacterized ES-specific gene, Esg-1, was found to be exclusively associated with pluripotency. We suggest that pluripotency requires a set of genes not expressed in other cell types, whereas lineage-restricted stem cells, like TS cells, express genes predictive of their differentiated lineage. [Supplemental material is available online at www.genome.org and http://lgsun.grc.nia.nih.gov/microarray/data.html]
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Cited by
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Spontaneous differentiation of germ cells from human embryonic stem cells in vitro
Clark, A. T. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh088 · Cited by 503
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Bhattacharya, B., Miura, T., Brandenberger, R., Mejido, J., Luo, Y., Yang, A. X., Joshi, B. H., Ginis, I., Thies, R. S., Amit, M., et al. (2004) · Blood · doi:10.1182/blood-2003-09-3314 · Cited by 451
Obokata, H., Sasai, Y., Niwa, H., Kadota, M., Andrabi, M., Takata, N., Tokoro, M., Terashita, Y., Yonemura, S., Vacanti, C. A., et al. (2014) · Nature · doi:10.1038/nature13599 · Cited by 313
Self-citationRetractedHamatani, T., Daikoku, T., Wang, H., Matsumoto, H., Carter, M. G., Ko, M. S. H., & Dey, S. K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402597101 · Cited by 254
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Metadata
- Authors
- Tanaka, T. S., Kunath, T., Kimber, W. L., Jaradat, S. A., Stagg, C. A., Usuda, M., Yokota, T., Niwa, H., Rossant, J., & Ko, M. S. H.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-12-01
- Volume
- 12
- Issue
- 12
- Pages
- 1921-1928
- ISSN
- 1088-9051 (ISSN-L)
- 1549-5469
- OpenAlex
- W2130683659
- Cited by
- 226
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Tanaka, T. S., Kunath, T., Kimber, W. L., Jaradat, S. A., Stagg, C. A., Usuda, M., Yokota, T., Niwa, H., Rossant, J., & Ko, M. S. H. (2002). Gene Expression Profiling of Embryo-Derived Stem Cells Reveals Candidate Genes Associated With Pluripotency and Lineage Specificity. Genome Research. https://doi.org/10.1101/gr.670002
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