Optimization of visual training for full recovery from severe amblyopia in adults
Open accessAbstract
The severe amblyopia induced by chronic monocular deprivation is highly resistant to reversal in adulthood. Here we use a rodent model to show that recovery from deprivation amblyopia can be achieved in adults by a two-step sequence, involving enhancement of synaptic plasticity in the visual cortex by dark exposure followed immediately by visual training. The perceptual learning induced by visual training contributes to the recovery of vision and can be optimized to drive full recovery of visual acuity in severely amblyopic adults.
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The plasticity reactivated by dark exposure can be harnessed to promote recovery from severe amblyopia.
“Importantly, the plasticity that is reactivated by dark exposure (DE) can be harnessed to promote the recovery from severe amblyopia (He et al., 2007; Montey and Quinlan, 2011; Eaton et al., 2016).”
From Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9 (2017) · cites this paper as Eaton et al., 2016
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References 53 · Cited by 28
- Authors
- Eaton, N. C., Sheehan, H. M., & Quinlan, E. M.
- Affiliations
- University of Maryland, College Park (US)
- Corresponding author
- Quinlan, Elizabeth M.
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2016-01-19
- Volume
- 23
- Issue
- 2
- Pages
- 99-103
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC4749829
- OpenAlex
- W2293092122
- Cited by
- 28
- References
- 53
- Citations by year
- 2024: 2 · 2022: 5 · 2020: 1 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 2
- Type
- posted content
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Learning & Memory (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Eye Institute (R01EY016431)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Health Sciences › Medicine › Epidemiology › Ophthalmology and Visual Impairment Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- amblyopia, monocular deprivation, perceptual learning, visual training, dark exposure, synaptic plasticity, visual cortex, visual acuity, rodent models
- MeSH terms
- Amblyopia, Animals, Disease Models, Animal, Photic Stimulation, Sensory Deprivation, Sensory Thresholds, Vision, Monocular, Recovery of Function, Rats, Long-Evans
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