A different recruitment of the lateral and basolateral amygdala promotes contextual or elemental conditioned association in Pavlovian fear conditioning
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Convergent data suggest dissociated roles for the lateral (LA) and basolateral (BLA) amygdaloid nuclei in fear conditioning, depending on whether a discrete conditioned stimulus (CS)–unconditional stimulus (US) or context–US association is considered. Here, we show that pretraining inactivation of the BLA selectively impaired conditioning to context. In contrast, inactivation of the LA disrupted conditioning to the discrete tone CS, but also either impaired or enhanced contextual conditioning, depending on whether the context was in the foreground or in the background. Hence, these findings refine the current model of the amygdala function in emotional learning by showing that the BLA and the LA not only differentially contribute to elemental and context–US association, but also promote, through their interaction, the most relevant of these two associations.
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The absence of cues in the predictable context may have signaled relative safety, but the predictable context was not safe in an absolute sense because it was associated with cue-related shock.
“Therefore, the absence of cues in Pcxt may have signaled relative safety; however, unlike Ncxt, Pcxt was not a safe context in an absolute sense because Pcxt was associated with cue-related shock, much like the context in background contextual conditioning studies (Calandreau et al., 2005).”
From Phasic and sustained fear in humans elicits distinct patterns of brain activity (2011) · cites this paper as Calandreau et al., 2005
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References 49 · Cited by 99
- Authors
- Calandreau, L., Desmedt, A., Decorte, L., & Jaffard, R.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2005-07
- Volume
- 12
- Issue
- 4
- Pages
- 383-388
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC1183256
- OpenAlex
- W2031471928
- Cited by
- 99
- References
- 49
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 5 · 2013: 6 · 2012: 3
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- lateral amygdala, basolateral amygdala, fear conditioning, contextual conditioning, conditioned stimulus, emotional learning
- MeSH terms
- Acoustic Stimulation, Amygdala, Anesthetics, Local, Animals, Behavior, Animal, Conditioning, Classical, Fear, Lidocaine, Male, Mice, Inbred C57BL, Microinjections, Mice
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