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On the Regulation of DNA Replication in Bacteria
Abstract
The deoxyribonucleotide sequence containing the genetic information of a cell participates in two distinct chemical processes. In the first one, generally called replication, free deoxyribonucleotides are linearly assembled by specific base-pairing to form an identical sequence, or replica of the original structure. The second process, or transcription, allows the genetic material to perform its physiological functions consisting essentially in the production of specific proteins at a suitable rate. As a first step, transcription involves the production of messengers which carry to the protein-forming-centers the information necessary to specify the structure of the polypeptide chains. Messenger synthesis by DNA is a process probably closely similar to that of replication, with the differences that it involves ribo-, instead of deoxyribonucleotides and that, in all likelihood, only one of the DNA strands is used for copying into an RNA transcript.
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Citations
Cited by
Clewell, D. B., & Helinski, D. R. (1972) · Journal of Bacteriology · doi:10.1128/jb.110.3.1135-1146.1972 · Cited by 349
The origin recognition complex: from simple origins to complex functions
Bell, S. P. (2002) · Genes & Development · doi:10.1101/gad.969602 · Cited by 288
Covalently Linked RNA-DNA Molecule as Initial Product of RNA Tumour Virus DNA Polymerase
VERMA, I. M., MEUTH, N. L., BROMFELD, E., MANLY, K. F., & BALTIMORE, D. (1971) · Nature New Biology · doi:10.1038/newbio233131a0 · Cited by 144
From Water and Ions to Crowded Biomacromolecules: In Vivo Structuring of a Prokaryotic Cell
Spitzer, J. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00010-11 · Cited by 77
The dynamics of the RNA world: insights and challenges
Kun, Á., Szilágyi, A., Könnyű, B., Boza, G., Zachar, I., & Szathmáry, E. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12700 · Cited by 65
Metadata
- Authors
- Jacob, F., Brenner, S., & Cuzin, F.
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1963-01-01
- Volume
- 28
- Issue
- 0
- Pages
- 329-348
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2166153420
- Cited by
- 1,445
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- closed
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- Jacob, F., Brenner, S., & Cuzin, F. (1963). On the Regulation of DNA Replication in Bacteria. Cold Spring Harbor Symposia on Quantitative Biology. https://doi.org/10.1101/sqb.1963.028.01.048
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