The origin recognition complex: from simple origins to complex functions
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Eukaryotic DNA replication is an intricate process that requires the coordinate and tightly regulated action of numerous molecular machines. Eukaryotic cells must choose hundreds if not thousands of origins of replication and assemble multiple proteins or protein complexes at these sites. During S phase, these complexes are activated in a reproducible, temporal program to generate twice this number of replication fork machines dedicated to DNA synthesis. Moreover, these machines must overcome the highly packaged nature of the eukaryotic genome to access all DNA sites, without excep
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Coherent sets of negative interactions involving the ORC linked functionally related complexes, including the MCM and GINS complexes.
“coherent sets of negative interactions involving the ORC, which specifies sites of initiation of DNA replication throughout the genome (31), linked functionally related complexes, including the MCM (Mini-Chromosome Maintenance) and the GINS (Go, Ichi, Ni, San) complexes”
From A global genetic interaction network maps a wiring diagram of cellular function (2016) · cites this paper as [31]
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Shore, D. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00493-6 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
A global genetic interaction network maps a wiring diagram of cellular function
Costanzo, M., VanderSluis, B., Koch, E. N., Baryshnikova, A., Pons, C., Tan, G., Wang, W., Usaj, M., Hanchard, J., Lee, S. D., et al. (2016) · Science · doi:10.1126/science.aaf1420 · Cited by 1,240 · see citing works
- Authors
- Bell, S. P.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Bell, Stephen P.
- ORCID
- Bell, Stephen P.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-03-15
- Volume
- 16
- Issue
- 6
- Pages
- 659-672
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2156360673
- Cited by
- 288
- References
- 115
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 11 · 2015: 5 · 2014: 8 · 2013: 7 · 2012: 8
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5r01gm058701-04)
- National Institute of General Medical Sciences (GM58701, GM52339, R01GM052339)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- origin recognition complex, origin of replication, eukaryotic DNA replication, S phase, origin activation, chromatin accessibility
- MeSH terms
- Adenosine Triphosphatases, Adenosine Triphosphate, Animals, Binding Sites, Cell Cycle, Chromatin, DNA, DNA-Binding Proteins, Escherichia coli, Models, Biological, Mutation, Phosphorylation, Saccharomyces cerevisiae, Origin Recognition Complex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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