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Frameshift Mutagenesis in Salmonella
Abstract
In bacteriophage, acridine mutagens such as proflavine add or delete nucleotides from the DNA. If the addition or deletion of nucleotides is not a multiple of 3 bases, the translation of the genetic message which occurs in unpunctuated triplets is shifted out of frame (Crick, Barnett, Brenner, and Watts-Tobin, 1961). These mutations are called frameshift mutations. In contrast to the results with bacteriophage systems, attempts to mutate bacteria with proflavine or similar acridines have met with little success (Orgel, 1965).
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Cited by
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An Improved Bacterial Test System for the Detection and Classification of Mutagens and Carcinogens
Ames, B. N., Lee, F. D., & Durston, W. E. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.3.782 · Cited by 1,532
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Ames, B. N. (1979) · Science · doi:10.1126/science.373122 · Cited by 586
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Leist, M., Ghallab, A., Graepel, R., Marchan, R., Hassan, R., Bennekou, S. H., Limonciel, A., Vinken, M., Schildknecht, S., Waldmann, T., et al. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-2045-3 · Cited by 394
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Metadata
- Authors
- Ames, B. N., & Whitfield, H. J.
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1966-01-01
- Volume
- 31
- Issue
- 0
- Pages
- 221-225
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2028130925
- Cited by
- 216
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- closed
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