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Unequal Crossover and the Evolution of Multigene Families
Abstract
The 18 S and 28 S ribosomal RNAs in eukaryotes are coded by hundreds of identical or nearly identical genes which I will refer to coUectively as the rRNA family. There are about 500 such genes in the frog Xenopus laevis (Buongiorno-Nardelli et al., 1972) which I will assume to form a single cluster of tendemly repeated genes. The repeated unit in this rRNA family contains not only the "gene" portion, from which the rRNA molecules are transcribed, but also a "spacer," which has no known function (Wensink and Brown, 1971; Miller and Beatty, 1969). Within one species of animal all the rRNA repeats are very similar or identical, but there are striking differences between the repeats in different species (Brown et al., 1972). Most of the interspecies differences reside in the spacer; the gene portion, which is presumably under more intense selective pressure, shows much less phylogenetic variation.
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Citations
Cited by
Concerted and Birth-and-Death Evolution of Multigene Families
Nei, M., & Rooney, A. P. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.073003.112240 · Cited by 1,298
Strand, M., Prolla, T. A., Liskay, R. M., & Petes, T. D. (1993) · Nature · doi:10.1038/365274a0 · Cited by 1,077
Wahl, G. M., Padgett, R. A., & Stark, G. R. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86945-4 · Cited by 451
Unequal meiotic recombination within tandem arrays of yeast ribosomal DNA genes
PETES, T. (1980) · Cell · doi:10.1016/s0092-8674(80)80052-3 · Cited by 342
Gene Amplification and Drug Resistance in Cultured Murine Cells
Schimke, R. T., Kaufman, R. J., Alt, F. W., & Kellems, R. F. (1978) · Science · doi:10.1126/science.715457 · Cited by 314
Metadata
- Authors
- Smith, G. P.
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1974-01-01
- Volume
- 38
- Issue
- 0
- Pages
- 507-513
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W1966621001
- Cited by
- 362
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- closed
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