Cited by 1,298Chromosomal and Genetic VariationsGenomics and Phylogenetic StudiesEvolution and Genetic Dynamics

Concerted and Birth-and-Death Evolution of Multigene Families

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Nei, Masatoshi, Rooney, Alejandro P.·2005·Annual Review of Genetics

Abstract

Until around 1990, most multigene families were thought to be subject to concerted evolution, in which all member genes of a family evolve as a unit in concert. However, phylogenetic analysis of MHC and other immune system genes showed a quite different evolutionary pattern, and a new model called birth-and-death evolution was proposed. In this model, new genes are created by gene duplication and some duplicate genes stay in the genome for a long time, whereas others are inactivated or deleted from the genome. Later investigations have shown that most non-rRNA genes including highly conserved histone or ubiquitin genes are subject to this type of evolution. However, the controversy over the two models is still continuing because the distinction between the two models becomes difficult when sequence differences are small. Unlike concerted evolution, the model of birth-and-death evolution can give some insights into the origins of new genetic systems or new phenotypic characters.

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Crossref · 10.1146/annurev.genet.39.073003.112240

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Authors
Nei, M., & Rooney, A. P.
Affiliations
  • Pennsylvania State University (US)
  • Agricultural Research Service (US)
Venue
Annual Review of Genetics
Published
2005-12-01
Volume
39
Issue
1
Pages
121-152
ISSN
  • 0066-4197 (ISSN-L)
  • 1545-2948
OpenAlex
W2128296317
Cited by
1,298
References
189
Citations by year
2026: 51 · 2025: 47 · 2024: 52 · 2023: 56 · 2022: 56 · 2021: 76 · 2020: 78 · 2019: 60 · 2018: 56 · 2017: 57 · 2016: 65 · 2015: 60 · 2014: 63 · 2013: 74 · 2012: 69
FWCI
5.57
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Eye Institute
  • National Institute of General Medical Sciences (R01GM020293, GM020293-32)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords
concerted evolution, birth-and-death evolution, gene family, gene duplication, gene inactivation, gene deletion, histone genes, ubiquitin genes, MHC genes, immune system genes, gene family evolution
MeSH terms
Animals, Multigene Family, Humans, Selection, Genetic, Evolution, Molecular

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