Concerted and Birth-and-Death Evolution of Multigene Families
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Until around 1990, most multigene families were thought to be subject to concerted evolution, in which all member genes of a family evolve as a unit in concert. However, phylogenetic analysis of MHC and other immune system genes showed a quite different evolutionary pattern, and a new model called birth-and-death evolution was proposed. In this model, new genes are created by gene duplication and some duplicate genes stay in the genome for a long time, whereas others are inactivated or deleted from the genome. Later investigations have shown that most non-rRNA genes including highly conserved histone or ubiquitin genes are subject to this type of evolution. However, the controversy over the two models is still continuing because the distinction between the two models becomes difficult when sequence differences are small. Unlike concerted evolution, the model of birth-and-death evolution can give some insights into the origins of new genetic systems or new phenotypic characters.
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Gene gains and losses have been considered as one of the most significant contributors to functional changes.
“Gene gains and losses have been considered as one of the most significant contributors to functional changes.”
From Whole genomic DNA sequencing and comparative genomic analysis of<i>Arthrospira platensis</i>: high genome plasticity and genetic diversity (2016) · cites this paper as [28]
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“Gene gains and losses have been considered as one of the most significant contributors to functional changes.(28) To further characterize the differences among several A.”
Background
- Authors
- Nei, M., & Rooney, A. P.
- Affiliations
- Pennsylvania State University (US)
- Agricultural Research Service (US)
- ORCID
- Rooney, Alejandro P.
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 2005-12-01
- Volume
- 39
- Issue
- 1
- Pages
- 121-152
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- PMC
- PMC1464479
- OpenAlex
- W2128296317
- Cited by
- 1,298
- References
- 189
- Citations by year
- 2026: 51 · 2025: 47 · 2024: 52 · 2023: 56 · 2022: 56 · 2021: 76 · 2020: 78 · 2019: 60 · 2018: 56 · 2017: 57 · 2016: 65 · 2015: 60 · 2014: 63 · 2013: 74 · 2012: 69
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Annual Review of Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute
- National Institute of General Medical Sciences (R01GM020293, GM020293-32)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- concerted evolution, birth-and-death evolution, gene family, gene duplication, gene inactivation, gene deletion, histone genes, ubiquitin genes, MHC genes, immune system genes, gene family evolution
- MeSH terms
- Animals, Multigene Family, Humans, Selection, Genetic, Evolution, Molecular
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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