The DOI matches its Crossref record.
Origin-defective Mutants of SV40
Abstract
We have described a new technique for the isolation and propagation of nonconditionally lethal mutants. We have used this method to generate mutants of SV40 that contain a defective origin of DNA replication. Using these mutants, we have established the following: (1) SV40 DNA replication and early transcription are functionally separate. (2) A functional viral origin of DNA replication is not necessary for the maintenance of transformation. (3) The lack of the origin of SV40 DNA replication does not affect the efficiency of transformation when nonpermissive cells are transfected by DNA using the calcium technique.
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Cited by
Cussenot, O., Berthon, P., Berger, R., Mowszowicz, I., Faille, A., Hojman, F., Teillac, P., Le Duc, A., & Calvo, F. (1991) · Journal of Urology · doi:10.1016/s0022-5347(17)37953-3 · Cited by 121
Metadata
- Authors
- Gluzman, Y., Frisque, R. J., & Sambrook, J.
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1980-01-01
- Volume
- 44
- Issue
- 0
- Pages
- 293-300
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2146269058
- Cited by
- 174
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Origin-defective Mutants of SV40. https://app.cochat.ai/papers/10.1101/sqb.1980.044.01.033
- The paper
- Gluzman, Y., Frisque, R. J., & Sambrook, J. (1980). Origin-defective Mutants of SV40. Cold Spring Harbor Symposia on Quantitative Biology. https://doi.org/10.1101/sqb.1980.044.01.033
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
