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Molecular Biology of Neuronal Geometry: Expression of Neurofilament Genes Influences Axonal Diameter
Abstract
Comparisons of the shapes of particular neurons in organisms with the same genotype demonstrate hat al-though the detailed geometry of the neurons may differ, the basic form of these cells is preserved (Macagno 1980). These observations suggest that the information that determines the basic form of these neurons is heri-table, and this raises a fundamental question for molec-ular neurobiology: How is information that is encoded in the genome xpressed into the specific geometries of the many different types of neurons that exist in ner-vous systems? One of the important keys to the solution of this problem resides within neuronal cytoskeletons, because these structures represent he supporting framework that defines the shape of the nerve cell (Hill-man 1980). The geometry of the neuron is an external
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“Several lines of evidence indicate that the various components of the neuronal cytoskeleton are crucial for the differentiation, elaboration, and maintenance of axons and dendrites (for reviews, see Lasek et al., 1983;Solomon, 1981;Solomon and Zurn, 198 1).”
From Immunocytochemical localization of tubulin and microtubule-associated protein 2 during the development of hippocampal neurons in culture (1986) · cites this paper as Lasek et al., 1983
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de Waegh, S. M., Lee, V. M. ‐., & Brady, S. T. (1992) · Cell · doi:10.1016/0092-8674(92)90183-d · Cited by 743
Neurofilament gene expression: a major determinant of axonal caliber.
Hoffman, P. N., Cleveland, D. W., Griffin, J. W., Landes, P. W., Cowan, N. J., & Price, D. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3472 · Cited by 719
Neurofilaments as biomarkers in neurological disorders — towards clinical application
Khalil, M., Teunissen, C. E., Lehmann, S., Otto, M., Piehl, F., Ziemssen, T., Bittner, S., Sormani, M. P., Gattringer, T., Abu‐Rumeileh, S., et al. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-00955-x · Cited by 503
Intermediate filaments mediate cytoskeletal crosstalk
Chang, L., & Goldman, R. D. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1438 · Cited by 386
Hurd, D. D., & Saxton, W. M. (1996) · Genetics · doi:10.1093/genetics/144.3.1075 · Cited by 379
Metadata
- Authors
- Lasek, R. J., Oblinger, M. M., & Drake, P. F.
- Affiliations
- Case Western Reserve University (US)
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1983-01-01
- Volume
- 48
- Issue
- 0
- Pages
- 731-744
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2083544461
- Cited by
- 128
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2013: 1 · 2012: 1
- Type
- posted content
- Language
- en
- Open access
- closed
- Locations
- Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Paralyzed Veterans of America
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- axon diameter, neuronal cytoskeleton, gene expression
- MeSH terms
- Animals, Aplysia, Axons, Axonal Transport, Cytoskeleton, Genes, Intermediate Filament Proteins, Microtubules, Molecular Weight, Nerve Tissue Proteins, Neurons
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