Cited by 182Origins and Evolution of LifeRNA and protein synthesis mechanismsPaleontology and Stratigraphy of Fossils

The DOI matches its Crossref record.

Which Organic Compounds Could Have Occurred on the Prebiotic Earth?

Miller, S.L.·1987·Cold Spring Harbor Symposia on Quantitative Biology

DOI 10.1101/sqb.1987.052.01.005

Open this paper in CoChat — free account

Abstract

In the past three decades, a wide variety of experiments have been designed to simulate conditions on the primitive earth and to demonstrate how organic compounds that made up the first living organisms were synthesized. This paper reviews this work and indicates the status of such syntheses. There is too much material to review in detail, and the reader is directed to a number of more complete discussions (Miller and Orgel 1974; Kenyon and Steinman 1969; Lemmon 1970).

Integrity signals

Registry

Crossref · 10.1101/sqb.1987.052.01.005

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Still being checked.

Sorted by citations

The eightfold path to non-enzymatic RNA replication
Szostak, J. W. (2012) · Journal of Systems Chemistry · doi:10.1186/1759-2208-3-2 · Cited by 359
Allosteric Disulfide Bonds
Schmidt, B., Ho, L., & Hogg, P. J. (2006) · Biochemistry · doi:10.1021/bi0603064 · Cited by 342
Deciphering synonymous codons in the three domains of life: Co‐evolution with specific tRNA modification enzymes
Grosjean, H., de Crécy‐Lagard, V., & Marck, C. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.11.052 · Cited by 308
A universal trend of amino acid gain and loss in protein evolution
Jordan, I. K., Kondrashov, F. A., Adzhubei, I. A., Wolf, Y. I., Koonin, E. V., Kondrashov, A. S., & Sunyaev, S. (2005) · Nature · doi:10.1038/nature03306 · Cited by 297
Mineral–organic interfacial processes: potential roles in the origins of life
Cleaves, H. J., Scott, A. M., Hill, F. C., Leszczyński, J., Sahai, N., & Hazen, R. M. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35112a · Cited by 271
The Triplet Code From First Principles
Trifonov, E. N. (2004) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2004.10506975 · Cited by 246
Disulfides as Redox Switches: From Molecular Mechanisms to Functional Significance
Wouters, M. A., Fan, S. W., & Haworth, N. L. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2510 · Cited by 238
On the Origin of Single Chirality of Amino Acids and Sugars in Biogenesis
Hein, J. E., & Blackmond, D. G. (2012) · Accounts of Chemical Research · doi:10.1021/ar200316n · Cited by 218
Chemical self-replication of palindromic duplex DNA
Li, T., & Nicolaou, K. C. (1994) · Nature · doi:10.1038/369218a0 · Cited by 204
Etiology of Potentially Primordial Biomolecular Structures: From Vitamin B12to the Nucleic Acids and an Inquiry into the Chemistry of Life’s Origin: A Retrospective
Eschenmoser, A. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201103672 · Cited by 193
Evolution of Amino Acid Frequencies in Proteins Over Deep Time: Inferred Order of Introduction of Amino Acids into the Genetic Code
Brooks, D. J., Fresco, J. R., Lesk, A. M., & Singh, M. (2002) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a003988 · Cited by 192
Chemie von a‐Aminonitrilen. Aldomerisierung von Glycolaldehyd‐phosphat zu racemischen Hexose‐2,4,6‐triphosphaten und (in Gegenwart von Formaldehyd) racemischen Pentose‐2,4‐diphosphaten: rac‐Allose‐2,4,6‐triphosphat und rac‐Ribose‐2,4‐diphosphat sind die Reaktionshauptprodukte
Müller, D., Pitsch, S., Kittaka, A., Wagner, E., Wintner, C. E., Eschenmoser, A., & Ohlofjgewidmet, G. (1990) · Helvetica Chimica Acta · doi:10.1002/hlca.19900730526 · Cited by 216
Main‐chain conformational tendencies of amino acids
Anderson, R. J., Weng, Z., Campbell, R. K., & Jiang, X. (2005) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.20530 · Cited by 190
Prebiotic cytosine synthesis: A critical analysis and implications for the origin of life
Shapiro, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4396 · Cited by 172
Warum Pentose‐ und nicht Hexose‐Nucleinsäuren?? Teil I. Einleitung und Problemstellung, Konformationsanalyse für Oligonucleotid‐Ketten aus 2′,3′‐Dideoxyglucopyranosyl‐Bausteinen (‘Homo‐DNS’) sowie Betrachtungen zur Konformation von A‐ und B‐DNS
Eschenmoser, A., & Dobler, M. (1992) · Helvetica Chimica Acta · doi:10.1002/hlca.19920750120 · Cited by 169
Differential adsorption of nucleic acid bases: Relevance to the origin of life
Sowerby, S. J., Cohn, C. A., Heckl, W. M., & Holm, N. G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.820 · Cited by 166
Peptide nucleic acid (PNA): A model structure for the primordial genetic material?
Nielsen, P. E. (1993) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf01582083 · Cited by 157
Obcells as Proto-Organisms: Membrane Heredity, Lithophosphorylation, and the Origins of the Genetic Code, the First Cells, and Photosynthesis
Cavalier‐Smith, T. (2001) · Journal of Molecular Evolution · doi:10.1007/s002390010245 · Cited by 157
Mineral induced formation of sugar phosphates
Pitsch, S., Eschenmoser, A., Gedulin, B., Hui, S. T., & Arrhenius, G. (1995) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf01581773 · Cited by 155
What are antibiotics? Archaic functions for modern activities
DAVIES, J. E. (1990) · Molecular Microbiology · doi:10.1111/j.1365-2958.1990.tb00701.x · Cited by 157
One‐Pot TiO2‐Catalyzed Synthesis of Nucleic Bases and Acyclonucleosides from Formamide: Implications for the Origin of Life
Saladino, R., Ciambecchini, U., Crestini, C., Costanzo, G., Negri, R., & Mauro, E. D. (2003) · ChemBioChem · doi:10.1002/cbic.200300567 · Cited by 141
Carbohydrate Polymers at the Center of Life’s Origins: The Importance of Molecular Processivity
Stern, R., & Jedrzejas, M. J. (2008) · Chemical Reviews · doi:10.1021/cr078240l · Cited by 136
The prebiotic role of adenine: A critical analysis
Shapiro, R. (1995) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf01581575 · Cited by 137
Chiral Symmetry Breaking During the Self-Assembly of Monolayers from Achiral Purine Molecules
Sowerby, S. J., Heckl, W. M., & Petersen, G. B. (1996) · Journal of Molecular Evolution · doi:10.1007/bf02337512 · Cited by 109
Synthesis and Degradation of Nucleobases and Nucleic Acids by Formamide in the Presence of Montmorillonites
Saladino, R., Crestini, C., Ciambecchini, U., Ciciriello, F., Costanzo, G., & Mauro, E. D. (2004) · ChemBioChem · doi:10.1002/cbic.200400119 · Cited by 102
Prebiotic chemistry: A bioorganic perspective
Sutherland, J. D., & Whitfield, J. N. (1997) · Tetrahedron · doi:10.1016/s0040-4020(97)00438-9 · Cited by 96
The presence of codon-anticodon pairs in the acceptor stem of tRNAs.
Rodin, S. N., Rodin, A., & Ohno, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4537 · Cited by 96
Evolution of proteomes: fundamental signatures and global trends in amino acid compositions
Tekaia, F., & Yeramian, E. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-307 · Cited by 87
Physico-chemical Constraints Connected with the Coding Properties of the Genetic System
Lehmann, J. (2000) · Journal of Theoretical Biology · doi:10.1006/jtbi.1999.1045 · Cited by 89
The first peptides: The evolutionary transition between prebiotic amino acids and early proteins
van der Gulik, P. T. S., Massar, S., Gilis, D., Buhrman, H., & Rooman, M. J. (2009) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2009.09.004 · Cited by 90
Distinct Stages of Protein Evolution as Suggested by Protein Sequence Analysis
Trifonov, E. N., Kirzhner, A., Kirzhner, V. M., & Berezovsky, I. N. (2001) · Journal of Molecular Evolution · doi:10.1007/s002390010229 · Cited by 85
Increased Frequency of Cysteine, Tyrosine, and Phenylalanine Residues Since the Last Universal Ancestor
Brooks, D. J., & Fresco, J. R. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m100001-mcp200 · Cited by 79
Imprints of the genetic code in the ribosome
Johnson, D. B. F., & Wang, L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000704107 · Cited by 83
On the origin of the genetic code: signatures of its primordial complementarity in tRNAs and aminoacyl-tRNA synthetases
Rodin, S. N., & Rodin, A. S. (2008) · Heredity · doi:10.1038/sj.hdy.6801086 · Cited by 79
Synthesis and Degradation of Nucleic Acid Components by Formamide and Cosmic Dust Analogues
Saladino, R., Crestini, C., Neri, V., Brucato, J. R., Colangeli, L., Ciciriello, F., Mauro, E. D., & Costanzo, G. (2005) · ChemBioChem · doi:10.1002/cbic.200500035 · Cited by 78
Intercalation-Mediated Synthesis and Replication: A New Approach to the Origin of Life
Hud, N. V., & Anet, F. A. L. (2000) · Journal of Theoretical Biology · doi:10.1006/jtbi.2000.2084 · Cited by 63
Sequence fossils, triplet expansion, and reconstruction of earliest codons
Trifonov, E. N., & Bettecken, T. (1997) · Gene · doi:10.1016/s0378-1119(97)00479-4 · Cited by 62
Urey prize lecture: Planetary evolution and the origin of life
McKay, C. P. (1991) · Icarus · doi:10.1016/0019-1035(91)90128-g · Cited by 63
An asymmetric underlying rule in the assignment of codons: Possible clue to a quick early evolution of the genetic code via successive binary choices
Delarue, M. H. (2006) · RNA · doi:10.1261/rna.257607 · Cited by 60
The Possible Role of Volcanic Aquifers in Prebiologic Genesis of Organic Compounds and RNA
Washington, J. W. (2000) · Origins of Life and Evolution of Biospheres · doi:10.1023/a:1006692606492 · Cited by 59
Photo-production of lactate from glyoxylate: how minerals can facilitate energy storage in a prebiotic world
Guzmán, M. I., & Martin, S. T. (2010) · Chemical Communications · doi:10.1039/b924179e · Cited by 59
Protein function from its emergence to diversity in contemporary proteins
Goncearenco, A., & Berezovsky, I. N. (2015) · Physical Biology · doi:10.1088/1478-3975/12/4/045002 · Cited by 58
How Amino Acids and Peptides Shaped the RNA World
Van der Gulik, P., & Speijer, D. (2015) · Life · doi:10.3390/life5010230 · Cited by 55
Peptide antibiotics of the tuberactinomycin family as inhibitors of group I intron RNA splicing
Wank, H., Rogers, J., DAVIES, J. E., & Schroeder, R. (1994) · Journal of Molecular Biology · doi:10.1016/0022-2836(94)90007-8 · Cited by 55
Primordial Coding of Amino Acids by Adsorbed Purine Bases
Sowerby, S., Petersen, G. B., & Holm, N. (2002) · Origins of life and evolution of the biosphere · doi:10.1023/a:1013957812213 · Cited by 52
Basic units of protein structure, folding, and function
Berezovsky, I. N., Guarnera, E., & Zheng, Z. (2016) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2016.09.009 · Cited by 54
A Fission-Fusion Origin for Life
Norris, V., & Raine, D. J. (1998) · Origins of life and evolution of the biosphere · doi:10.1023/a:1006568226145 · Cited by 63
Fate of Prebiotic Adenine
Cohn, C. A., Hansson, T., Larsson, H., Sowerby, S. J., & Holm, N. G. (2001) · Astrobiology · doi:10.1089/153110701753593874 · Cited by 50
Evolutionary Patterns in the Sequence and Structure of Transfer RNA: Early Origins of Archaea and Viruses
Sun, F.-J., & Caetano‐Anollés, G. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000018 · Cited by 51
Infrared spectral investigations of UV irradiated nucleobases adsorbed on mineral surfaces
Fornaro, T., Brucato, J. R., Pace, E., Guidi, M. C., Branciamore, S., & Pucci, A. (2013) · Icarus · doi:10.1016/j.icarus.2013.07.024 · Cited by 52
Ätiologie potentiell primordialer Biomolekül‐Strukturen: Vom Vitamin B12zu den Nukleinsäuren und der Frage nach der Chemie der Entstehung des Lebens – ein Rückblick
Eschenmoser, A. (2011) · Angewandte Chemie · doi:10.1002/ange.201103672 · Cited by 50
The origin of the genetic code and of the earliest oligopeptides
Trifonov, E. N. (2009) · Research in Microbiology · doi:10.1016/j.resmic.2009.05.004 · Cited by 51
A Possible Prebiotic Origin on Volcanic Islands of Oligopyrrole-Type Photopigments and Electron Transfer Cofactors
Fox, S., & Strasdeit, H. (2013) · Astrobiology · doi:10.1089/ast.2012.0934 · Cited by 48
What is the Sugar Code?
Gabius, H., Čudić, M., Diercks, T., Kaltner, H., Kopitz, J., Mayo, K. H., Murphy, P. V., Oscarson, S., Roy, R., Schedlbauer, A., et al. (2021) · ChemBioChem · doi:10.1002/cbic.202100327 · Cited by 52
Extremophiles May Be Irrelevant to the Origin of Life
Cleaves, H. J., & Chalmers, J. H. (2004) · Astrobiology · doi:10.1089/153110704773600195 · Cited by 46
A New Classification Scheme of the Genetic Code
Wilhelm, T. E., & Nikolajewa, S. (2004) · Journal of Molecular Evolution · doi:10.1007/s00239-004-2650-7 · Cited by 43
DNA renaturation at the water-phenol interface
Goldar, A., & Sikorav, J. (2004) · The European Physical Journal E · doi:10.1140/epje/i2004-10011-7 · Cited by 45
Electronic Transitions of Protonated and Deprotonated Amino Acids in Aqueous Solution in the Region 145–300 nm Studied by Attenuated Total Reflection Far-Ultraviolet Spectroscopy
Goto, T., Ikehata, A., Morisawa, Y., & Ozaki, Y. (2013) · The Journal of Physical Chemistry A · doi:10.1021/jp4008416 · Cited by 44
Fougerite: the not so simple progenitor of the first cells
Duval, S., Baymann, F., Schoepp‐Cothenet, B., Trolard, F., Bourrié, G., Grauby, O., Branscomb, E., Russell, M. J., & Nitschke, W. (2019) · Interface Focus · doi:10.1098/rsfs.2019.0063 · Cited by 42
Simple Formation of an Abiotic Porphyrinogen in Aqueous Solution
Lindsey, J. S., Ptaszek, M., & Taniguchi, M. (2009) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-009-9168-3 · Cited by 44
Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication
Jia, T. Z., Fahrenbach, A. C., Kamat, N. P., Adamala, K. P., & Szostak, J. W. (2016) · Nature Chemistry · doi:10.1038/nchem.2551 · Cited by 44
Retracted
Guilt by association: The arginine case revisited
Knight, R. D., & Landweber, L. F. (2000) · RNA · doi:10.1017/s1355838200000145 · Cited by 44
Physical law not natural selection as the major determinant of biological complexity in the subcellular realm: new support for the pre-Darwinian conception of evolution by natural law
Denton, M. J., Dearden, P. K., & Sowerby, S. J. (2003) · Biosystems · doi:10.1016/s0303-2647(03)00100-x · Cited by 39
Evolutionary Patterns in the Sequence and Structure of Transfer RNA: A Window into Early Translation and the Genetic Code
Sun, F.-J., & Caetano‐Anollés, G. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002799 · Cited by 38
Incubating Life: Prebiotic Sources of Organics for the Origin of Life
Dalai, P., Kaddour, H., & Sahai, N. (2016) · Elements · doi:10.2113/gselements.12.6.401 · Cited by 38
A novel method for estimating ancestral amino acid composition and its application to proteins of the Last Universal Ancestor
Brooks, D. J., Fresco, J. R., & Singh, M. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth235 · Cited by 35
Evolution of tRNA recognition systems and tRNA gene sequences
Saks, M. E., & Sampson, J. (1995) · Journal of Molecular Evolution · doi:10.1007/bf00166619 · Cited by 36
Three stages in the evolution of the genetic code
Baumann, U., & Oro, J. A. (1993) · Biosystems · doi:10.1016/0303-2647(93)90089-u · Cited by 35
Origins of life: a route to nanotechnology
Sowerby, S. J., Holm, N. G., & Petersen, G. B. (2001) · Biosystems · doi:10.1016/s0303-2647(01)00130-7 · Cited by 34
Effect of Temperature on the Adsorption of Adenine
Sowerby, S. J., Mörth, C., & Holm, N. G. (2001) · Astrobiology · doi:10.1089/153110701753593883 · Cited by 33
The origin of the polycyclic aromatic hydrocarbons in meteorites
Wing, M. R., & Bada, J. L. (1991) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf01808308 · Cited by 30
Transition Metals Enhance the Adsorption of Nucleotides onto Clays: Implications for the Origin of Life
Hao, J., Mokhtari, M., Pedreira-Segade, U., Michot, L. J., & Daniel, I. (2018) · ACS Earth and Space Chemistry · doi:10.1021/acsearthspacechem.8b00145 · Cited by 27
Primordia Vita. Deconvolution from Modern Sequences.
Trifonov, E. N., Gabdank, I., Barash, D., & Sobolevsky, Y. (2006) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-006-9042-5 · Cited by 28
Adsorption of nucleic acid bases on magnesium oxide (MgO)
Fornaro, T., Brucato, J. R., Branciamore, S., & Pucci, A. (2012) · International Journal of Astrobiology · doi:10.1017/s1473550412000444 · Cited by 28
Nucleic Acids Bind to Nanoparticulate iron (II) Monosulphide in Aqueous Solutions
Hatton, B., & Rickard, D. T. (2008) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-008-9132-7 · Cited by 29
Origin of the Genetic Code: First Aminoacyl–tRNA Synthetases Could Replace Isofunctional Ribozymes When Only the Second Base of Codons Was Established
Rodin, S. N., & Rodin, A. S. (2006) · DNA and Cell Biology · doi:10.1089/dna.2006.25.365 · Cited by 27
Protein Modules Conserved Since LUCA
Sobolevsky, Y., & Trifonov, E. (2006) · Journal of Molecular Evolution · doi:10.1007/s00239-005-0190-4 · Cited by 26
Prebiotic synthesis of orotic acid parallel to the biosynthetic pathway
Yamagata, Y., Sasaki, K., Takaoka, O., Sano, S., INOMATA, K., KANEMITSU, K., Inoue, Y., & Matsumoto, I. (1990) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf01808133 · Cited by 23
Variation and Selection
Quinkert, G., Bang, H., & Reichert, D. (1996) · Helvetica Chimica Acta · doi:10.1002/hlca.19960790504 · Cited by 22
Comparison of the Frequency of Functional SH3 Domains with Different Limited Sets of Amino Acids Using mRNA Display
Tanaka, J., Yanagawa, H., & Doi, N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018034 · Cited by 18
Adsorption of nucleotides on clay surfaces: Effects of mineral composition, pH and solution salts
Mignon, P., Corbin, G., Crom, S. L., Marry, V., Hao, J., & Daniel, I. (2020) · Applied Clay Science · doi:10.1016/j.clay.2020.105544 · Cited by 20
Transfer RNA and the Origins of Diversified Life
Sun, F.-J., & Caetano‐Anollés, G. (2008) · Science Progress · doi:10.3184/003685008x360650 · Cited by 18
Molecular evolution from abiotic scratch
Trifonov, E. N., & Berezovsky, I. N. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03165-4 · Cited by 18
Biological Implications of Organic Compounds in Comets
Marcus, J. N., & Olsen, M. A. A. (1991) · Astrophysics and space science library · doi:10.1007/978-94-011-3378-4_19 · Cited by 19
Can prebiotic systems survive in the wild? An interference chemistry approach
Walton, C. R., Rimmer, P. B., & Shorttle, O. (2022) · Frontiers in Earth Science · doi:10.3389/feart.2022.1011717 · Cited by 18
Emergence of a Code in the Polymerization of Amino Acids along RNA Templates
Lehmann, J., Cibils, M. B., & Libchaber, A. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005773 · Cited by 18
The Reactions of Nitrogen Heterocycles with Acrolein: Scope and Prebiotic Significance
Cleaves, H. J. (2002) · Astrobiology · doi:10.1089/153110702762470509 · Cited by 18
Introduction to virus origins and their role in biological evolution
Domingo, E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816331-3.00001-5 · Cited by 21
Towards functional repertoire of the earliest proteins
Sobolevsky, Y., Guimarães, R. C., & Trifonov, E. N. (2012) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2012.735623 · Cited by 15
Greater GNN pattern bias in sequence elements encoding conserved residues of ancient proteins may be an indicator of amino acid composition of early proteins
Brooks, D. J., & Fresco, J. R. (2003) · Gene · doi:10.1016/s0378-1119(02)01176-9 · Cited by 17
Tracing Life back to elements
Trifonov, E. N. (2008) · Physics of Life Reviews · doi:10.1016/j.plrev.2008.03.001 · Cited by 15
Optimal growth temperature of prokaryotes correlates with class II amino acid composition
Klipcan, L., Safro, I., Temkin, B., & Safro, M. G. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.02.013 · Cited by 17
On the Origin of Glycome and Saccharide Recognition
Hirabayashi, J. (2004) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.16.63 · Cited by 16
Differential Oligomerization of Alpha versus Beta Amino Acids and Hydroxy Acids in Abiotic Proto-Peptide Synthesis Reactions
Frenkel‐Pinter, M., Jacobson, K. C., Eskew-Martin, J. C., Forsythe, J. G., Grover, M. A., Williams, L. D., & Hud, N. V. (2022) · Life · doi:10.3390/life12020265 · Cited by 16
Paley's watchmaker analogy and prebiotic synthetic chemistry in surfactant assemblies. Formaldehyde scavenging by pyrroles leading to porphyrins as a case study
Alexy, E. J., Hintz, C. W., Hughes, H. M., Taniguchi, M., & Lindsey, J. S. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob01409c · Cited by 14
Life Before RNA
Sowerby, S. J., & Petersen, G. B. (2002) · Astrobiology · doi:10.1089/153110702762027826 · Cited by 14
From Foundation Stones to Life: Concepts and Results
Maurel, M., & Leclerc, F. (2016) · Elements · doi:10.2113/gselements.12.6.407 · Cited by 14
Crick Wobble and Superwobble in Standard Genetic Code Evolution
Yarus, M. (2021) · Journal of Molecular Evolution · doi:10.1007/s00239-020-09985-7 · Cited by 13
The evolutionary significance of the long variable arm in transfer RNA
Sun, F., & Caetano‐Anollés, G. (2008) · Complexity · doi:10.1002/cplx.20255 · Cited by 13
Evolution of Animal Lectins
Hirabayashi, J., & Kasai, K.-I. (1998) · Progress in molecular and subcellular biology · doi:10.1007/978-3-642-48745-3_3 · Cited by 13

Authors: Miller, S. L.
Affiliations: University of California San Diego (US)
Corresponding author: Miller, S.L.
Venue: Cold Spring Harbor Symposia on Quantitative Biology
Publisher: Cold Spring Harbor Laboratory
Published: 1987-01-01
Volume: 52
Issue: 0
Pages: 17-27
ISSN: 0091-7451 (ISSN-L)
1943-4456
DOI: 10.1101/sqb.1987.052.01.005
OpenAlex: W2017119083
Cited by: 182
References: 0
Citations by year: 2026: 4 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 10 · 2015: 6 · 2013: 7 · 2012: 10
Type: posted content
Language: en
Open access: closed
Locations: Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Aeronautics and Space Administration
Topics: Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Physical Sciences › Earth and Planetary Sciences › Paleontology › Paleontology and Stratigraphy of Fossils
Keywords: prebiotic chemistry, origin of life, organic synthesis, Miller-Urey experiment, early Earth, nucleotides
MeSH terms: Origin of Life, Amino Acids, Catalysis, Purines, Pyrimidines, Radiation Effects, Thermodynamics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Which Organic Compounds Could Have Occurred on the Prebiotic Earth?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks