Prebiotic chemistry: A bioorganic perspective
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The low yields and lack of selectivity are among the major problems of prebiotic chemistry.
“The low yields and lack of selectivity are among the major problems of prebiotic chemistry (Sutherland and Whitfield, 1997).”
From The Astrobiology Primer v2.0 (2016) · cites this paper as Sutherland and Whitfield, 1997
Nucleobases can form nucleic acid chains under prebiotic, template-free conditions.
“Various studies have shown that amino acids can randomly polymerize to peptides (Plankensteiner et al., 2005), and nucleobases can form nucleic acid chains (Sutherland and Whitfield, 1997) under prebiotic, template-free conditions.”
From The Astrobiology Primer v2.0 (2016) · cites this paper as Sutherland and Whitfield, 1997
Cites
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The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
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Chiral selection in poly(C)-directed synthesis of oligo(G)
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Vitamin B<sub>12</sub>: Experiments Concerning the Origin of Its Molecular Structure
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Autocatalytic synthesis of a tetranucleotide analogue
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Studies in prebiotic synthesis
Fuller, W. D., Sanchez, R. A., & Orgel, L. E. (1972) · Journal of Molecular Biology · doi:10.1016/0022-2836(72)90383-x · Cited by 280 · see citing works
Prebiotic Ribose Synthesis: A Critical Analysis
Shapiro, R. (1988) · Origins of life and evolution of the biosphere · doi:10.1007/bf01808782 · Cited by 276 · see citing works
Cyanoacetylene in Prebiotic Synthesis
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Bildung einer zuckerartigen Substanz durch Synthese
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Urea-Inorganic Phosphate Mixtures as Prebiotic Phosphorylating Agents
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Which Organic Compounds Could Have Occurred on the Prebiotic Earth?
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Template-directed synthesis on the pentanucleotide CpCpGpCpC
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Martin, W., & Russell, M. J. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1183 · Cited by 856 · see citing works
On the origin of biochemistry at an alkaline hydrothermal vent
Martin, W., & Russell, M. J. (2007) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1881 · Cited by 771 · see citing works
Prebiotic Peptides: Molecular Hubs in the Origin of Life
Frenkel-Pinter, M., Samanta, M., Ashkenasy, G., & Leman, L. J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00664 · Cited by 354 · see citing works
A Reassessment of Prebiotic Organic Synthesis in Neutral Planetary Atmospheres
Cleaves, H. J., Chalmers, J. H., Lazcano, A., Miller, S. L., & Bada, J. L. (2008) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-007-9120-3 · Cited by 313 · see citing works
Selective prebiotic formation of RNA pyrimidine and DNA purine nucleosides
Xu, J., Chmela, V., Green, N. J., Russell, D. A., Janicki, M. J., Góra, R. W., Szabla, R., Bond, A. D., & Sutherland, J. D. (2020) · Nature · doi:10.1038/s41586-020-2330-9 · Cited by 176 · see citing works
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“Various studies have shown that amino acids can randomly polymerize to peptides (Planken- steiner et al., 2005), and nucleobases can form nucleic acid chains (Sutherland and Whitfield, 1997) under prebiotic, template-free conditions.”
Sousa, F. L., & Martin, W. F. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2014.02.001 · Cited by 100 · see citing works
Wieczorek, R., Adamala, K., Gasperi, T., Polticelli, F., & Stano, P. (2017) · Life · doi:10.3390/life7020019 · Cited by 53 · see citing works
Prebiotic Photochemical Coproduction of Purine Ribo- and Deoxyribonucleosides
Xu, J., Green, N. J., Russell, D. A., Liu, Z., & Sutherland, J. D. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c07403 · Cited by 38 · see citing works
Self-citationOn the applicability of Darwinian principles to chemical evolution that led to life
Perry, R. S., & Kolb, V. M. (2004) · International Journal of Astrobiology · doi:10.1017/s1473550404001892 · Cited by 24 · see citing works
- Authors
- Sutherland, J. D., & Whitfield, J. N.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Sutherland, John D
- ORCID
- Sutherland, John D
- Venue
- Tetrahedron
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 53
- Issue
- 34
- Pages
- 11493-11527
- ISSN
- 0040-4020 (ISSN-L)
- OpenAlex
- W1994646690
- Cited by
- 96
- References
- 12
- Citations by year
- 2022: 3 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Tetrahedron (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Reaction Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- prebiotic chemistry, β-anomer, nucleotide synthesis, uracil, thymine, RNA, DNA, quantum chemical calculations, origin of life
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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