Initiator Met-tRNA-independent Translation Mediated by an Internal Ribosome Entry Site Element in Cricket Paralysis Virus-like Insect Viruses
Abstract
In eukaryotic cells, the translation of the majority ofmessenger RNAs is initiated by a scanning mechanism(Kozak 1989) whereby the 40S ribosomal subunit is recruited to the 5′-terminal end of the capped mRNA as a43S complex, consisting of the 40S ribosome, the ternaryMet-tRNAi/eIF2-GTP complex, and factors eIF1A andeIF3 (Hershey and Merrick 2000). The 43S complex thenscans the mRNA in an ATP-dependent manner until it locates an appropriate start AUG where the 60S subunitjoins to form an 80S ribosome...
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Selected mRNAs must be able to bypass translational arrest, and it has been suggested that those containing small upstream open reading frames (uORFs) within their 5'-UTR regions or internal ribosome entry site (IRES) sequences are able to do so.
“Selected mRNAs must therefore be able to bypass this translational arrest, and it has been suggested that those containing small upstream open reading frames (uORFs) within their 5'-UTR regions or internal ribosome entry site (IRES) sequences are able to do so (278, 349).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [278]
Cites
The scanning model for translation: an update.
Kozak, M. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.2.229 · Cited by 3,485 · see citing works
Pelletier, J., & Sonenberg, N. (1988) · Nature · doi:10.1038/334320a0 · Cited by 1,953 · see citing works
Jang, S. K., Kräusslich, H., Nicklin, M. J. H., Duke, G. M., Palmenberg, A. C., & Wimmer, E. (1988) · Journal of Virology · doi:10.1128/jvi.62.8.2636-2643.1988 · Cited by 1,363 · see citing works
Internal ribosome entry sites in eukaryotic mRNA moleculesPreprint
Hellen, C. U. T., & Sarnow, P. (2001) · Genes & Development · doi:10.1101/gad.891101 · Cited by 977 · see citing works
Self-citationPestova, T. V., Shatsky, I. N., Fletcher, S. P., Jackson, R. J., & Hellen, C. U. T. (1998) · Genes & Development · doi:10.1101/gad.12.1.67 · Cited by 729 · see citing works
Self-citationPestova, T., Hellen, C., & Shatsky, I. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.6859 · Cited by 535 · see citing works
Self-citationTranslational Regulation of Yeast GCN4
Hinnebusch, A. G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.35.21661 · Cited by 526 · see citing works
The joining of ribosomal subunits in eukaryotes requires eIF5B
Pestova, T., Lomakin, I., Lee, J.-H., Choi, S. K., Dever, T., & Hellen, C. (2000) · Nature · doi:10.1038/35002118 · Cited by 433 · see citing works
Self-citationInitiation of Protein Synthesis from the A Site of the Ribosome
Wilson, J. E., Pestova, T. V., Hellen, C. U. T., & Sarnow, P. (2000) · Cell · doi:10.1016/s0092-8674(00)00055-6 · Cited by 430 · see citing works
Self-citationWilson, J. E., Powell, M. J., Hoover, S. E., & Sarnow, P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.4990-4999.2000 · Cited by 317 · see citing works
Self-citation5 Mechanism and Regulation of Initiator Methionyl-tRNA Binding to RibosomesPreprint
Hinnebusch, A. G. (2000) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969618.39.185 · Cited by 247 · see citing works
Migration of 40 S ribosomal subunits on messenger RNA in the presence of edeine.
Kozak, M., & Shatkin, A. J. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)46969-x · Cited by 202 · see citing works
Sasaki, J., & Nakashima, N. (1999) · Journal of Virology · doi:10.1128/jvi.73.2.1219-1226.1999 · Cited by 170 · see citing works
Methionine-independent initiation of translation in the capsid protein of an insect RNA virus
Sasaki, J., & Nakashima, N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.010426997 · Cited by 166 · see citing works
Kanamori, Y., & Nakashima, N. (2001) · RNA · doi:10.1017/s1355838201001741 · Cited by 141 · see citing works
Ramírez, M., Wek, R. C., de Aldana, C. R. V., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5801 · Cited by 127 · see citing works
Dever, T. E., Yang, W., Åström, S. U., et al. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.11.6351 · Cited by 122 · see citing works
2 The Pathway and Mechanism of Initiation of Protein SynthesisPreprint
Hershey, J. W. B., & Merrick, W. C. (2000) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969618.39.33 · Cited by 115 · see citing works
Reinganum, C., O'loughlin, G., & Hogan, T. (1970) · Journal of Invertebrate Pathology · doi:10.1016/0022-2011(70)90062-5 · Cited by 99 · see citing works
Characterization of Cricket Paralysis Virus-Induced Polypeptides in Drosophila Cells
Moore, N. F., Kearns, A., & Pullin, J. S. K. (1980) · Journal of Virology · doi:10.1128/jvi.33.1.1-9.1980 · Cited by 79 · see citing works
Odon, O. W., Kramer, G., Henderson, A. B., et al. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)62324-0 · Cited by 77 · see citing works
Sequence Requirements for Translation Initiation of Rhopalosiphum padi Virus ORF2
Domier, L. L., McCoppin, N. K., & D’Arcy, C. J. (2000) · Virology · doi:10.1006/viro.2000.0189 · Cited by 53 · see citing works
Picornalike Viruses of Insects
Christian, P. D., & Scotti, P. D. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5341-0_10 · Cited by 45 · see citing works
The small RNA-viruses of insects
Moore, N. F., & Tinsley, T. W. (1982) · Archives of Virology · doi:10.1007/bf01315220 · Cited by 44 · see citing works
Szer, W., & Kurylo-Borowska, Z. (1970) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(70)90580-0 · Cited by 43 · see citing works
Coward, P., & Dasgupta, A. (1992) · Journal of Virology · doi:10.1128/jvi.66.1.286-295.1992 · Cited by 32 · see citing works
[29] The Elongation steps in protein synthesis by eukaryotic ribosomes: Effects of antibiotics
Carrasco, L., Battaner, E., & Vázquez, D. (1974) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(74)30031-6 · Cited by 24 · see citing works
Dasgupta, A. (1998) · Frontiers in bioscience · doi:10.2741/a359 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
Yung, H.-W., Calabrese, S., Hynx, D., Hemmings, B. A., Cetin, I., Charnock-Jones, D. S., & Burton, G. J. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.071193 · Cited by 388 · see citing works
Yung, H. W., Cox, M., van Patot, M. T., & Burton, G. J. (2012) · The FASEB Journal · doi:10.1096/fj.11-190082 · Cited by 112 · see citing works
- Authors
- JAN, E., THOMPSON, S. R., WILSON, J. E., PESTOVA, T. V., HELLEN, C. U. T., & SARNOW, P.
- Affiliations
- State University of New York (US)
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-01-01
- Volume
- 66
- Issue
- 0
- Pages
- 285-292
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2159220380
- Cited by
- 46
- References
- 28
- Citations by year
- 2023: 1 · 2022: 2 · 2019: 3 · 2018: 6 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 4
- Type
- posted content
- Language
- en
- Open access
- closed
- Locations
- Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- internal ribosome entry site, cricket paralysis virus, insect viruses, translation initiation, scanning mechanism, start codon recognition
- MeSH terms
- Animals, Base Sequence, Gryllidae, Guanosine Triphosphate, Insect Viruses, Molecular Sequence Data, Nucleic Acid Conformation, Ribosomes, RNA, Ribosomal, Saccharomyces cerevisiae, Protein Biosynthesis, Eukaryotic Initiation Factor-2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review