The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Genome-wide Mutational Diversity in an Evolving Population of Escherichia coli
Open accessAbstract
The level of genetic variation in a population is the result of a dynamic tension between evolutionary forces. Mutations create variation, certain frequency-dependent interactions may preserve diversity, and natural selection purges variation. New sequencing technologies offer unprecedented opportunities to discover and characterize the diversity present in evolving microbial populations on a whole-genome scale. By sequencing mixed-population samples, we have identified single-nucleotide polymorphisms (SNPs) present at various points in the history of an Escherichia coli population that has evolved for almost 20 years from a founding clone. With 50-fold genome coverage, we were able to catch beneficial mutations as they swept to fixation, discover contending beneficial alleles that were eliminated by clonal interference, and detect other minor variants possibly adapted to a new ecological niche. Additionally, there was a dramatic increase in genetic diversity late in the experiment after a mutator phenotype evolved. Still finer-resolution details of the structure of genetic variation and how it changes over time in microbial evolution experiments will enable new applications and quantitative tests of population genetic theory.
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Versatile and open software for comparing large genomes
Kurtz, S., Phillippy, A., Delcher, A. L., Smoot, M., Shumway, M., Antonescu, C., & Salzberg, S. L. (2004) · Genome Biology · doi:10.1186/gb-2004-5-2-r12 · Cited by 5,254
Evolution Experiments with Microorganisms: The Dynamics and Genetic Bases of Adaptation
Elena, S. F., & Lenski, R. E. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1088 · Cited by 1,386
Self-citationBlount, Z. D., Borland, C. Z., & Lenski, R. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803151105 · Cited by 840
Self-citationThe population genetics of ecological specialization in evolving Escherichia coli populations
Cooper, V. S., & Lenski, R. E. (2000) · Nature · doi:10.1038/35037572 · Cited by 519
Self-citation
Cited by
Kawecki, T. J., Lenski, R. E., Ebert, D., Hollis, B., Olivieri, I., & Whitlock, M. C. (2012) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2012.06.001 · Cited by 807
Self-citationGenomic analysis of a key innovation in an experimental Escherichia coli population
Blount, Z. D., Barrick, J. E., Davidson, C. J., & Lenski, R. E. (2012) · Nature · doi:10.1038/nature11514 · Cited by 612
Self-citationSecond-Order Selection for Evolvability in a Large Escherichia coli Population
Woods, R. J., Barrick, J. E., Cooper, T. F., Shrestha, U., Kauth, M. R., & Lenski, R. E. (2011) · Science · doi:10.1126/science.1198914 · Cited by 328
Self-citationMutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load
Wielgoss, S., Barrick, J. E., Tenaillon, O., Wiser, M. J., Dittmar, W. J., Cruveiller, S., Chane-Woon-Ming, B., Médigue, C., Lenski, R. E., & Schneider, D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219574110 · Cited by 292
Self-citationEvolutionary insight from whole‐genome sequencing of experimentally evolved microbes
DETTMAN, J. R., RODRIGUE, N., MELNYK, A. H., WONG, A., BAILEY, S. F., & KASSEN, R. (2012) · Molecular Ecology · doi:10.1111/j.1365-294x.2012.05484.x · Cited by 160
Metadata
- Authors
- Barrick, J. E., & Lenski, R. E.
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-01-01
- Volume
- 74
- Issue
- 0
- Pages
- 119-129
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2123805784
- Cited by
- 174
- References
- 4
- Type
- posted content
- Language
- en
- Open access
- bronze
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