Second-Order Selection for Evolvability in a Large Escherichia coli Population
Open accessAbstract
Descendants of bacterial lineages that retained adaptation potential outcompeted competitors of higher fitness.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
With suitable neutral genetic markers, fitness differences can be easily monitored during laboratory evolution of microbial cells.
“With suitable neutral genetic markers, this fitness difference can be easily monitored during laboratory evolution of microbial cells [34,59].”
From Adaptive laboratory evolution—Principles and applications for biotechnology (2013) · cites this paper as [34]
The long-term E. coli adaptation experiment by Lenski's group has exceeded 50000 generations.
“This single parallel E. coli adaptation experiment is already exceeding 50000 generations [33-35].”
From Adaptive laboratory evolution—Principles and applications for biotechnology (2013) · cites this paper as [34]
During the first few thousand generations, glucose-evolved E. coli cultures developed larger cell size and a lower final cell density as compared with the ancestor.
“During the first few thousand generations, glucose-evolved cultures developed larger cell size and a lower final cell density as compared with the ancestor [34].”
From Adaptive laboratory evolution—Principles and applications for biotechnology (2013) · cites this paper as [34]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Lenski, R. E., Rose, M. R., Simpson, S. C., & Tadler, S. C. (1991) · The American Naturalist · doi:10.1086/285289 · Cited by 1,582 · see citing works
Self-citationGenome evolution and adaptation in a long-term experiment with Escherichia coli
Barrick, J. E., Yu, D. S., Yoon, S. H., Jeong, H., Oh, T. K., Schneider, D., Lenski, R. E., & Kim, J. F. (2009) · Nature · doi:10.1038/nature08480 · Cited by 1,184 · see citing works
Self-citationThe fate of competing beneficial mutations in an asexual population
Gerrish, P. J., & Lenski, R. E. (1998) · Genetica · doi:10.1023/a:1017067816551 · Cited by 783 · see citing works
Self-citationThe fate of competing beneficial mutations in an asexual population
Gerrish, P. J., & Lenski, R. E. (1998) · Contemporary issues in genetics and evolution · doi:10.1007/978-94-011-5210-5_12 · Cited by 721 · see citing works
Self-citationPERSPECTIVE:SIGN EPISTASIS AND GENETIC CONSTRAINT ON EVOLUTIONARY TRAJECTORIES
Weinreich, D. M., Watson, R. A. R., & Chao, L. (2005) · Evolution · doi:10.1554/04-272 · Cited by 640 · see citing works
Pigliucci, M. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2278 · Cited by 579 · see citing works
The fate of competing beneficial mutations in an asexual population.
Gerrish, P. J., & Lenski, R. E. (1998) · PubMed · Cited by 520 · see citing works
Self-citationCooper, T. F., Rozen, D. E., & Lenski, R. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0334340100 · Cited by 440 · see citing works
Self-citationThe Evolution of Genetic Architecture
Hansen, T. F. (2006) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev.ecolsys.37.091305.110224 · Cited by 420 · see citing works
Diminishing Returns from Mutation Supply Rate in Asexual Populations
G., J. A., de Visser, J. A. G. M., Zeyl, C., Gerrish, P. J., Blanchard, J. L., & Lenski, R. E. (1999) · Science · doi:10.1126/science.283.5400.404 · Cited by 374 · see citing works
Self-citationTests of parallel molecular evolution in a long-term experiment with Escherichia coli
Woods, R. J., Schneider, D., Winkworth, C. L., Riley, M. A., & Lenski, R. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602917103 · Cited by 316 · see citing works
Self-citationKao, K. C., & Sherlock, G. J. (2008) · Nature Genetics · doi:10.1038/ng.280 · Cited by 314 · see citing works
Cooper, V. S., Schneider, D., Blot, M., & Lenski, R. E. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.9.2834-2841.2001 · Cited by 277 · see citing works
Self-citationEvolvability of an RNA virus is determined by its mutational neighbourhood
Burch, C. L., & Chao, L. (2000) · Nature · doi:10.1038/35020564 · Cited by 276 · see citing works
COMPETITION BETWEEN HIGH AND LOW MUTATING STRAINS OF<i>ESCHERICHIA COLI</i>
Chao, L., & Cox, E. C. (1983) · Evolution · doi:10.1111/j.1558-5646.1983.tb05521.x · Cited by 255 · see citing works
An Equivalence Principle for the Incorporation of Favorable Mutations in Asexual Populations
Hegreness, M., Noam Shoresh, F., Hartl, D. L., & Kishony, R. (2006) · Science · doi:10.1126/science.1122469 · Cited by 250 · see citing works
Mutators, Population Size, Adaptive Landscape and the Adaptation of Asexual Populations of Bacteria
Tenaillon, O., Toupance, B., Nagard, H. L., Taddéi, F., & Godelle, B. (1999) · Genetics · doi:10.1093/genetics/152.2.485 · Cited by 233 · see citing works
Beneficial mutations and the dynamics of adaptation in asexual populations
Sniegowski, P., & Gerrish, P. J. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2009.0290 · Cited by 213 · see citing works
Clonal interference in large populations
Park, S., & Krug, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705778104 · Cited by 183 · see citing works
Genome-wide Mutational Diversity in an Evolving Population of Escherichia coliPreprint
Barrick, J. E., & Lenski, R. E. (2009) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2009.74.018 · Cited by 174 · see citing works
Self-citationEvolution of global regulatory networks during a long‐term experiment with<i>Escherichia coli</i>
Philippe, N., Crozat, E., Lenski, R. E., & Schneider, D. (2007) · BioEssays · doi:10.1002/bies.20629 · Cited by 145 · see citing works
Self-citationEscherichia coli rpoB Mutants Have Increased Evolvability in Proportion to Their Fitness Defects
Barrick, J. E., Kauth, M. R., Strelioff, C. C., & Lenski, R. E. (2010) · Molecular Biology and Evolution · doi:10.1093/molbev/msq024 · Cited by 139 · see citing works
Self-citationClonal Interference, Multiple Mutations and Adaptation in Large Asexual Populations
Fogle, C. A., Nagle, J. L., & Desai, M. M. (2008) · Genetics · doi:10.1534/genetics.108.090019 · Cited by 137 · see citing works
Long-Term Experimental Evolution in Escherichia coli. XII. DNA Topology as a Key Target of Selection
Crozat, E., Philippe, N., Lenski, R. E., Geiselmann, J., & Schneider, D. (2004) · Genetics · doi:10.1534/genetics.104.035717 · Cited by 133 · see citing works
Self-citationda Silva, J., Coetzer, M., Nedellec, R., Pastore, C., & Mosier, D. E. (2010) · Genetics · doi:10.1534/genetics.109.112458 · Cited by 122 · see citing works
Xu, Y., Heath, R. J., Li, Z., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100195200 · Cited by 119 · see citing works
Competition Between High and Low Mutating Strains of Escherichia coli
Chao, L., & Cox, E. C. (1983) · Evolution · doi:10.2307/2408181 · Cited by 119 · see citing works
SIGN EPISTASIS AND GENETIC CONSTRAINT ON EVOLUTIONARY TRAJECTORIES
Weinreich, D., Watson, R. A. R., & Chao, L. (2005) · Cited by 117 · see citing works
Robustness promotes evolvability of thermotolerance in an RNA virus
McBride, R. C., Ogbunugafor, C. B., & Turner, P. E. (2008) · BMC Evolutionary Biology · doi:10.1186/1471-2148-8-231 · Cited by 105 · see citing works
Heterogeneous Adaptive Trajectories of Small Populations on Complex Fitness Landscapes
Rozen, D. E., Habets, M. G. J. L., Handel, A., & de Visser, J. A. G. M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001715 · Cited by 104 · see citing works
Experimental evolution: experimental evolution and evolvability
Colegrave, N., & Collins, S. (2008) · Heredity · doi:10.1038/sj.hdy.6801095 · Cited by 91 · see citing works
Cooper, T. F., Remold, S. K., Lenski, R. E., & Schneider, D. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040035 · Cited by 69 · see citing works
Self-citationElena, S. F., & Lenski, R. E. (1997) · Evolution · doi:10.1111/j.1558-5646.1997.tb03953.x · Cited by 68 · see citing works
Self-citationStanek, M. T., Cooper, T. F., & Lenski, R. E. (2009) · BMC Evolutionary Biology · doi:10.1186/1471-2148-9-302 · Cited by 42 · see citing works
Self-citationElena, S. F., & Lenski, R. E. (1997) · Evolution · doi:10.2307/2411035 · Cited by 33 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Adaptive laboratory evolution—Principles and applications for biotechnology
Dragosits, M., & Mattanovich, D. (2013) · Microbial Cell Factories · doi:10.1186/1475-2859-12-64 · Cited by 827 · see citing works
Empirical fitness landscapes and the predictability of evolution
de Visser, J. A. G. M., & Krug, J. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3744 · Cited by 715 · see citing works
Kawecki, T. J., Lenski, R. E., Ebert, D., Hollis, B., Olivieri, I., & Whitlock, M. C. (2012) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2012.06.001 · Cited by 807 · see citing works
Self-citationAm i self-conscious? (or does self-organization entail self-consciousness?)
Friston, K. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00579 · Cited by 197 · see citing works
Evolutionary insight from whole‐genome sequencing of experimentally evolved microbes
DETTMAN, J. R., RODRIGUE, N., MELNYK, A. H., WONG, A., BAILEY, S. F., & KASSEN, R. (2012) · Molecular Ecology · doi:10.1111/j.1365-294x.2012.05484.x · Cited by 160 · see citing works
Ryall, B., Eydallin, G., & Ferenci, T. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05028-11 · Cited by 160 · see citing works
Multiscale Evolutionary Dynamics of Host-Associated Microbiomes
Ferreiro, A., Crook, N., Gasparrini, A. J., & Dantas, G. (2018) · Cell · doi:10.1016/j.cell.2018.02.015 · Cited by 127 · see citing works
Bryant, J., Chewapreecha, C., & Bentley, S. D. (2012) · Future Microbiology · doi:10.2217/fmb.12.108 · Cited by 98 · see citing works
Deatherage, D. E., Traverse, C. C., Wolf, L. N., & Barrick, J. E. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2014.00468 · Cited by 93 · see citing works
Self-citation
- Authors
- Woods, R. J., Barrick, J. E., Cooper, T. F., Shrestha, U., Kauth, M. R., & Lenski, R. E.
- Affiliations
- Michigan State University (US)
- University of Houston (US)
- Corresponding author
- Woods, Robert J.
- Barrick, Jeffrey E.
- Lenski, Richard E.
- Venue
- Science
- Published
- 2011-03-18
- Volume
- 331
- Issue
- 6023
- Pages
- 1433-1436
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3176658
- OpenAlex
- W2123832578
- Cited by
- 328
- References
- 35
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 16 · 2023: 4 · 2022: 14 · 2021: 18 · 2020: 10 · 2019: 10 · 2018: 19 · 2017: 22 · 2016: 18 · 2015: 25 · 2014: 28 · 2013: 42 · 2012: 39
- FWCI
- 30.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Texas ScholarWorks (Texas Digital Library) (submittedVersion)
- Funders
- Defense Advanced Research Projects Agency (HR0011-09-1-0055)
- National Institutes of Health (K99GM087550)
- National Science Foundation (DEB1019989)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Social Sciences › Sociology and Political Science › Evolutionary Game Theory and Cooperation
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy and History of Science
- Keywords
- evolvability, Escherichia coli, long-term evolution experiment, asexual lineages, competitive fitness, beneficial mutations, genetic interactions, regulatory mutations
- MeSH terms
- Adaptation, Physiological, Epistasis, Genetic, Escherichia coli, Biological Evolution, Genes, Bacterial, Genotype, Models, Genetic, Mutation, Selection, Genetic, Genetic Fitness
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
