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Cited by 27Genomics and Chromatin DynamicsEpigenetics and DNA MethylationChromatin Remodeling and Cancer

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Chromatin in the Nuclear Landscape

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Beck, D. B., Bonasio, R., Kaneko, S., Li, G., Li, G., Margueron, R., Oda, H., Sarma, K., Sims, R. J., Son, J., Trojer, P., Reinberg, D.·2010·Cold Spring Harbor Symposia on Quantitative Biology
DOI 10.1101/sqb.2010.75.052PMC PMC3832107
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Abstract

Chromatin affects many, if not all aspects, of nuclear organization and function. For this reason, we have focused our attention on elucidating some of the basic mechanisms regulating the formation and maintenance of chromatin, specifically concerning Polycomb repressive complex 2 (PRC2) and PR-Set7. PRC2 is responsible for catalyzing trimethylation of lysine 27 of histone H3 and thus has a critical role in the formation of facultative heterochromatin. PR-Set7 is responsible for catalyzing monomethylation of lysine 20 of histone H4 and is required for proper cell cycle progression and DNA damage response. We have also expanded our work to establish novel techniques and approaches to determine how chromatin is spatially regulated within the nuclear landscape.

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Crossref · 10.1101/sqb.2010.75.052

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  • H3K27me3 is enriched at facultative heterochromatin, whereas H3K9me3 is associated with constitutive heterochromatin at telomeres and centromeres.

    “Histone H3K27me3 is enriched at so-called “facultative” heterochromatin, whereas H3K9me3 is associated with “constitutive” heterochromatin at telomeres and centromeres [7].”

    From Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling (2014) · cites this paper as [7]

    The Introduction states that constitutive heterochromatin is enriched for H3K9me3 and facultative heterochromatin for H3K27me3. It does not specify telomeres or centromeres as locations of the constitutive heterochromatin described in the claim (searched both terms). Page numbers are unavailable in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • H3K27me3 and H3K9me3 are associated with distinct forms of transcriptionally silent heterochromatin.

    “Trimethylation of histone H3 lysine 27 (H3K27me3) and lysine 9 (H3K9me3) are associated with distinct forms of transcriptionally silent heterochromatin.”

    From Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling (2014) · cites this paper as [7]

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Metadata

Authors
Beck, D. B., Bonasio, R., Kaneko, S., Li, G., Li, G., Margueron, R., Oda, H., Sarma, K., Sims, R. J., Son, J., Trojer, P., & Reinberg, D.
Affiliations
Howard Hughes Medical Institute (US)
ORCID
Venue
Cold Spring Harbor Symposia on Quantitative Biology
Publisher
Cold Spring Harbor Laboratory
Published
2010-01-01
Volume
75
Issue
0
Pages
11-22
ISSN
  • 0091-7451 (ISSN-L)
  • 1943-4456
DOI
10.1101/sqb.2010.75.052
PMC
PMC3832107
OpenAlex
W2124265430
Cited by
27
References
2
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 2
Type
posted content
Language
en
Open access
Locations
  • Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institute of General Medical Sciences (GM 64844, R01GM064844)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
chromatin, nuclear organization, polycomb repressive complex 2, PR-Set7, H3K27me3, facultative heterochromatin, cell cycle progression, DNA damage response
MeSH terms
Animals, Cell Cycle, Chromatin, DNA Damage, Heterochromatin, Humans, Repressor Proteins, Protein Structure, Tertiary, Polycomb-Group Proteins

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