SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.

Vaquero, Alejandro; Scher, Michael; Erdjument-Bromage, Hediye; Tempst, Paul; Serrano, Lourdes; Reinberg, Danny

doi:10.1038/nature06268

Cited by 439Genomics and Chromatin DynamicsEpigenetics and DNA MethylationNuclear Structure and Function

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.

Vaquero, Alejandro, Scher, Michael, Erdjument-Bromage, Hediye, Tempst, Paul, Serrano, Lourdes, Reinberg, Danny·2007·Nature

DOI 10.1038/nature06268

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Abstract

In contrast to stably repressive, constitutive heterochromatin and stably active, euchromatin, facultative heterochromatin has the capacity to alternate between repressive and activated states of transcription. As such, it is an instructive source to understand the molecular basis for changes in chromatin structure that correlate with transcriptional status. Sirtuin 1 (SIRT1) and suppressor of variegation 3-9 homologue 1 (SUV39H1) are amongst the enzymes responsible for chromatin modulations associated with facultative heterochromatin formation. SUV39H1 is the principal enzyme responsible for the accumulation of histone H3 containing a tri-methyl group at its lysine 9 position (H3K9me3) in regions of heterochromatin. SIRT1 is an NAD+-dependent deacetylase that targets histone H4 at lysine 16 (refs 3 and 4), and through an unknown mechanism facilitates increased levels of H3K9me3 (ref. 3). Here we show that the mammalian histone methyltransferase SUV39H1 is itself targeted by the histone deacetylase SIRT1 and that SUV39H1 activity is regulated by acetylation at lysine residue 266 in its catalytic SET domain. SIRT1 interacts directly with, recruits and deacetylates SUV39H1, and these activities independently contribute to elevated levels of SUV39H1 activity resulting in increased levels of the H3K9me3 modification. Loss of SIRT1 greatly affects SUV39H1-dependent H3K9me3 and impairs localization of heterochromatin protein 1. These findings demonstrate a functional link between the heterochromatin-related histone methyltransferase SUV39H1 and the histone deacetylase SIRT1.

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SIRT1 deacetylase modulates SUV39H1 by deacetylating SUV39H1 K266 and by deacetylating H3K9Ac to allow SUV39H1 methylation.
“SUV39H1 function is also modulated by the SIRT1 deacetylase, which regulates SUV39H1 in two separate ways: (1) by deacetylating SUV39H1 lysine residue 266 (K266) (Vaquero et al., 2007) and (2) by deacetylating lysine 9 of histone H3 (H3K9Ac) to allow SUV39H1 methylation (Vaquero et al., 2004, 2007).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Vaquero et al., 2007

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“SUV39H1 function is also modulated by the SIRT1 deacetylase, which regulates SUV39H1 in two separate ways: (1) by deacetylating SUV39H1 lysine residue 266 (K266) (Vaquero et al., 2007) and (2) by deacetylating lysine 9 of histone H3 (H3K9Ac) to allow SUV39H1 methylation (Vaquero et al., 2004, 2007).”
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Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.
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Authors: Vaquero, A., Scher, M., Erdjument-Bromage, H., Tempst, P., Serrano, L., & Reinberg, D.
Affiliations: Howard Hughes Medical Institute (US)
Memorial Sloan Kettering Cancer Center (US)
Rutgers, The State University of New Jersey (US)
Corresponding author: Reinberg, Danny
ORCID: Vaquero, Alejandro
Tempst, Paul
Serrano, Lourdes
Reinberg, Danny
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2007-11-15
Volume: 450
Issue: 7168
Pages: 440-444
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature06268
OpenAlex: W2012147370
Cited by: 439
References: 17
Citations by year: 2026: 17 · 2025: 17 · 2024: 22 · 2023: 11 · 2022: 24 · 2021: 20 · 2020: 23 · 2019: 20 · 2018: 24 · 2017: 32 · 2016: 16 · 2015: 29 · 2014: 24 · 2013: 36 · 2012: 32
FWCI: 8.07
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords: SIRT1, SUV39H1, facultative heterochromatin, heterochromatin formation, histone deacetylase, histone methyltransferase, H3K9me3, HP1, chromatin regulation, transcriptional repression
MeSH terms: Histone Methyltransferases, Acetylation, Amino Acid Sequence, Animals, Cell Line, Fibroblasts, HeLa Cells, Heterochromatin, Histones, Humans, Methyltransferases, Molecular Sequence Data, Niacinamide, Protein Binding, Histone-Lysine N-Methyltransferase, Protein Methyltransferases, Repressor Proteins, Sirtuins, Chromatin Assembly and Disassembly, Mice, Sirtuin 1

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SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.

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