Liver-specific agents for contrast-enhanced MRI: role in oncological imaging
Open accessAbstract
Liver-specific magnetic resonance (MR) contrast agents are increasingly used in evaluation of the liver. They are effective in detection and morphological characterization of lesions, and can be useful for evaluation of biliary tree anatomy and liver function. The typical appearances and imaging pitfalls of various tumours at MR imaging performed with these agents can be understood by the interplay of pharmacokinetics of these contrast agents and transporter expression of the tumour. This review focuses on the applications of these agents in oncological imaging.
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Small molecule gadolinium chelates show less body retention compared to nanoparticle-based formulations like SPION.
“In addition, small molecule gadolinium chelates show less body retention compared to nanoparticle-based formulations like SPION [152].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [152]
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- [25]Tanimoto A Higuchi N Ueno A Reduction of ringing artifacts in the arterial phase of gadoxetic acid-enhanced dynamic MR imaging Magn Reson Med Sci 2012 11 91 97 22790295
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
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- Authors
- Thian, Y. L., Riddell, A. M., & Koh, D.-M.
- Affiliations
- Royal Marsden NHS Foundation Trust (GB)
- Corresponding author
- Koh, Dow-Mu
- Venue
- Cancer Imaging
- Publisher
- E-MED LTD
- Published
- 2013
- Volume
- 13
- Issue
- 4
- Pages
- 567-579
- ISSN
- 1470-7330 (ISSN-L)
- PMC
- PMC3893895
- OpenAlex
- W1972276317
- Cited by
- 64
- References
- 91
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 4 · 2020: 9 · 2019: 9 · 2018: 2 · 2017: 6 · 2016: 3 · 2015: 12
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Imaging (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research UK (16464)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- liver-specific contrast agents, contrast-enhanced MRI, liver tumors, hepatocellular carcinoma, biliary tract imaging, liver function assessment, contrast agent pharmacokinetics, transporter expression, liver lesion characterization
- MeSH terms
- Bile Duct Neoplasms, Bile Ducts, Intrahepatic, Contrast Media, Hemangioma, Carcinoma, Hepatocellular, Humans, Image Enhancement, Liver Neoplasms, Magnetic Resonance Imaging, Meglumine, Organometallic Compounds, Cholangiocarcinoma, Gadolinium DTPA
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