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Micromechanical mass sensors for biomolecular detection in a physiological environment
Abstract
Micromechanical cantilever arrays are used to measure time-resolved adsorption of tiny masses based on protein-ligand interactions. Here, streptavidin-biotin interactions are investigated in a physiological environment. A measurement method is introduced using higher flexural modes of a silicon cantilever in order to enhance the sensitivity of mass detection. Modeling the cantilever vibration in liquid allows the measurement of absolute mass changes. We show time-resolved mass adsorption of final 7+/-0.7 ng biotinylated latex beads. The sensitivity obtained is about 2.5 pg/Hz measuring at a center frequency of 750 kHz.
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Cited by
Weighing of biomolecules, single cells and single nanoparticles in fluid
Burg, T. P., Godin, M., Knudsen, S. M., Shen, W., Carlson, G., Foster, J. S., Babcock, K., & Manalis, S. R. (2007) · Nature · doi:10.1038/nature05741 · Cited by 1,213
Micro- and nanomechanical sensors for environmental, chemical, and biological detection
Waggoner, P. S., & Craighead, H. G. (2007) · Lab on a Chip · doi:10.1039/b707401h · Cited by 678
Biosensors based on nanomechanical systems
Tamayo, J., Kosaka, P. M., Ruz, J. J., San Paulo, Á., & Calleja, M. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35293a · Cited by 391
Diamond for bio-sensor applications
Nebel, C. E., Rezek, B., Shin, D., Uetsuka, H., & Yang, N. (2007) · Journal of Physics D: Applied Physics · doi:10.1088/0022-3727/40/20/s21 · Cited by 253
Metadata
- Authors
- Braun, T., Barwich, V., Ghatkesar, M. K., Bredekamp, A. H., Gerber, C., Hegner, M., & Lang, H. P.
- Venue
- Physical Review E
- Publisher
- American Physical Society (APS)
- Published
- 2005-09-14
- Volume
- 72
- Issue
- 3
- Pages
- 031907-031907
- ISSN
- 1539-3755 (ISSN-L)
- 1550-2376
- OpenAlex
- W2135232292
- Cited by
- 168
- References
- 0
- FWCI
- 11.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Braun, T., Barwich, V., Ghatkesar, M. K., Bredekamp, A. H., Gerber, C., Hegner, M., & Lang, H. P. (2005). Micromechanical mass sensors for biomolecular detection in a physiological environment. Physical Review E. https://doi.org/10.1103/physreve.72.031907
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