Forced transport of deformable containers through narrow constrictions
Open accessAbstract
We study, numerically and analytically, the forced transport of deformable containers through a narrow constriction. Our central aim is to quantify the competition between the constriction geometry and the active forcing, regulating whether and at which speed a container may pass through the constriction and under what conditions it gets stuck. We focus, in particular, on the interrelation between the force that propels the container and the radius of the channel, as these are the external variables that may be directly controlled in both artificial and physiological settings. We present lattice Boltzmann simulations that elucidate in detail the various phases of translocation and present simplified analytical models that treat two limiting types of these membrane containers: deformational energy dominated by the bending or stretching contribution. In either case we find excellent agreement with the full simulations, and our results reveal that not only the radius but also the length of the constriction determines whether or not the container will pass.
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The force produced by a realistic number of molecular motors is capable of transporting an endosome through constrictions with similar dimensions as spine necks.
“A recent study that explicitly modeled the translocation of vesicles through narrow constrictions has shown that the force produced by a realistic number of molecular motors is capable of transporting an endosome through constrictions with similar dimensions as spine necks (Kusters et al., 2014b).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Kusters et al., 2014b
Translocation of endosomes through spine necks is highly sensitive to the size of the neck and the applied force.
“However, this translocation is highly sensitive to the size of the neck and the applied force.”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Kusters et al., 2014b
Decreasing the size of the neck could hamper the active transport of receptors.
“Although this study did not explicitly model the actin meshwork in the neck, nor the potential deformation of the spine neck itself, it suggests that decreasing the size of the neck, in contrast to its effect on passive diffusion, could hamper the active transport of receptors (Kusters et al., 2014b).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Kusters et al., 2014b
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References 33 · Cited by 40
- Authors
- Kusters, R., van der Heijden, T., Kaoui, B., Harting, J., & Storm, C.
- Affiliations
- University of Bayreuth (DE)
- Eindhoven University of Technology (NL)
- Venue
- Physical Review E
- Publisher
- American Physical Society (APS)
- Published
- 2014-09-10
- Volume
- 90
- Issue
- 3
- Pages
- 033006-033006
- ISSN
- 1539-3755 (ISSN-L)
- 1550-2376
- OpenAlex
- W2106044437
- Cited by
- 40
- References
- 33
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 1 · 2015: 1 · 2014: 1
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Physical Review E (publishedVersion)
- PubMed (publishedVersion)
- TU/e Research Portal (publishedVersion, other-oa)
- University of Twente Research Information (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- TU/e Research Portal (submittedVersion)
- TU/e Research Portal (submittedVersion, other-oa)
- University of Twente Research Information (submittedVersion)
- arXiv (Cornell University)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (10787)
- Topics
- Physical Sciences › Engineering › Computational Mechanics › Lattice Boltzmann Simulation Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Physical Sciences › Engineering › Biomedical Engineering › Nanopore and Nanochannel Transport Studies
- Keywords
- membrane translocation, narrow constrictions, membrane bending energy, channel radius
- MeSH terms
- Computer Simulation, Elasticity, Models, Theoretical, Motion, Mechanical Phenomena
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