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Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS)
Abstract
By exploiting the extremely large effective cross sections ( ${10}^{\ensuremath{-}17}--{10}^{\ensuremath{-}16}{\mathrm{cm}}^{2}/\mathrm{molecule}$) available from surface-enhanced Raman scattering (SERS), we achieved the first observation of single molecule Raman scattering. Measured spectra of a single crystal violet molecule in aqueous colloidal silver solution using one second collection time and about $2\ifmmode\times\else\texttimes\fi{}{10}^{5}\mathrm{W}/{\mathrm{cm}}^{2}$ nonresonant near-infrared excitation show a clear ``fingerprint'' of its Raman features between 700 and $1700{\mathrm{cm}}^{\ensuremath{-}1}$. Spectra observed in a time sequence for an average of 0.6 dye molecule in the probed volume exhibited the expected Poisson distribution for actually measuring 0, 1, 2, or 3 molecules.
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Citations
Cited by
Shell-isolated nanoparticle-enhanced Raman spectroscopy
Li, J. F., Huang, Y. F., Ding, Y., Yang, Z. L., Li, S. B., Zhou, X. S., Fan, F. R., Zhang, W., Zhou, Z. Y., Wu, D. Y., et al. (2010) · Nature · doi:10.1038/nature08907 · Cited by 3,559
Surface-enhanced Raman scattering
Campion, A., & Kambhampati, P. (1998) · Chemical Society Reviews · doi:10.1039/a827241z · Cited by 3,401
Ghosh, S. K., & Pal, T. (2007) · Chemical Reviews · doi:10.1021/cr0680282 · Cited by 2,782
Shape Control of Colloidal Metal Nanocrystals
Tao, A. R., Habas, S., & Yang, P. (2008) · Small · doi:10.1002/smll.200701295 · Cited by 2,408
In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q., Chen, G. Z., Shin, D. M., Yang, L., Young, A. N., Wang, M. D., & Nie, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1377 · Cited by 2,201
Metadata
- Authors
- Kneipp, K., Wang, Y., Kneipp, H., Perelman, L. T., Itzkan, I., Dasari, R. R., & Feld, M. S.
- Venue
- Physical Review Letters
- Publisher
- American Physical Society (APS)
- Published
- 1997-03-03
- Volume
- 78
- Issue
- 9
- Pages
- 1667-1670
- ISSN
- 0031-9007 (ISSN-L)
- 1079-7114
- OpenAlex
- W1999173254
- Cited by
- 6,816
- References
- 0
- FWCI
- 24.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kneipp, K., Wang, Y., Kneipp, H., Perelman, L. T., Itzkan, I., Dasari, R. R., & Feld, M. S. (1997). Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS). Physical Review Letters. https://doi.org/10.1103/physrevlett.78.1667
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