The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Sequence Dependent Rigidity of Single Stranded DNA
Abstract
Single stranded DNA (ssDNA) equilibrium dynamics are investigated using a fluorophore/quencher-labeled hairpin structure which thermally fluctuates between open and closed states. Temporal correlations of the fluorescence fluctuations are used to determine the energy barrier to conformational change. We find that ssDNA distortion is purely entropic for $\mathrm{poly}(T)$ but requires an additional enthalpy of $+0.5\phantom{\rule{0ex}{0ex}}\mathrm{kcal}\ifmmode \dot{}\else \.{}\fi{}\mathrm{mol}{}^{\ensuremath{-}1}\ifmmode \dot{}\else \.{}\fi{}\mathrm{base}{}^{\ensuremath{-}1}$ for $\mathrm{poly}(A)$, consistent with the disruption of base stacking. Such sequence dependent dynamics challenge the classical model of ssDNA as a completely flexible coil.
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Self-citationPersistence Length of Single-Stranded DNA
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Biophysical chemistry. Part III, The behavior of biologicalmacromolecules
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Cited by
The Thermodynamics of DNA Structural Motifs
SantaLucia, J., & Hicks, D. (2004) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.32.110601.141800 · Cited by 1,314
Woodside, M. T., Behnke-Parks, W. M., Larizadeh, K., Travers, K., Herschlag, D., & Block, S. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511048103 · Cited by 474
Introducing improved structural properties and salt dependence into a coarse-grained model of DNA
Snodin, B. E. K., Randisi, F., Mosayebi, M., Šulc, P., Schreck, J. S., Romano, F., Ouldridge, T. E., Tsukanov, R., Nir, E., Louis, A. A., et al. (2015) · The Journal of Chemical Physics · doi:10.1063/1.4921957 · Cited by 381
Sequence-dependent thermodynamics of a coarse-grained DNA model
Šulc, P., Romano, F., Ouldridge, T. E., Rovigatti, L., Doye, J. P. K., & Louis, A. A. (2012) · The Journal of Chemical Physics · doi:10.1063/1.4754132 · Cited by 338
Noncanonical secondary structures arising from non-B DNA motifs are determinants of mutagenesis
Georgakopoulos-Soares, I., Morganella, S., Jain, N., Hemberg, M., & Nik-Zainal, S. (2018) · Genome Research · doi:10.1101/gr.231688.117 · Cited by 146
Metadata
- Authors
- Goddard, N. L., Bonnet, G., Krichevsky, O., & Libchaber, A.
- Venue
- Physical Review Letters
- Publisher
- American Physical Society (APS)
- Published
- 2000-09-11
- Volume
- 85
- Issue
- 11
- Pages
- 2400-2403
- ISSN
- 0031-9007 (ISSN-L)
- 1079-7114
- OpenAlex
- W2081315067
- Cited by
- 296
- References
- 15
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Goddard, N. L., Bonnet, G., Krichevsky, O., & Libchaber, A. (2000). Sequence Dependent Rigidity of Single Stranded DNA. Physical Review Letters. https://doi.org/10.1103/physrevlett.85.2400
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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