The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Overstretching B-DNA: The Elastic Response of Individual Double-Stranded and Single-Stranded DNA Molecules
Abstract
Single molecules of double-stranded DNA (dsDNA) were stretched with force-measuring laser tweezers. Under a longitudinal stress of ∼65 piconewtons (pN), dsDNA molecules in aqueous buffer undergo a highly cooperative transition into a stable form with 5.8 angstroms rise per base pair, that is, 70% longer than B-form dsDNA. When the stress was relaxed below 65 pN, the molecules rapidly and reversibly contracted to their normal contour lengths. This transition was affected by changes in the ionic strength of the medium and the water activity or by cross-linking of the two strands of dsDNA. Individual molecules of single-stranded DNA were also stretched giving a persistence length of 7.5 angstroms and a stretch modulus of 800 pN. The overstretched form may play a significant role in the energetics of DNA recombination.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Observation of a single-beam gradient force optical trap for dielectric particles
Ashkin, A., Dziedzic, J. M., Bjorkholm, J. E., & Chu, S. (1986) · Optics Letters · doi:10.1364/ol.11.000288 · Cited by 7,030
Principles of Nucleic Acid Structure
(2008) · Elsevier eBooks · doi:10.1016/b978-0-12-369507-9.x5001-8 · Cited by 4,504
Manning, G. S. (1978) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500002031 · Cited by 2,937
Marko, J. F., & Siggia, E. D. (1995) · Macromolecules · doi:10.1021/ma00130a008 · Cited by 2,307
Entropic Elasticity of λ-Phage DNA
Bustamante, C., Marko, J. F., Siggia, E. D., & Smith, S. (1994) · Science · doi:10.1126/science.8079175 · Cited by 2,154
Self-citationPredicting DNA duplex stability from the base sequence
Breslauer, K. J., Frank, R., Blöcker, H., & Marky, L. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.3746 · Cited by 1,837
Direct Mechanical Measurements of the Elasticity of Single DNA Molecules by Using Magnetic Beads
Smith, S. B., Finzi, L., & Bustamante, C. (1992) · Science · doi:10.1126/science.1439819 · Cited by 1,817
Self-citationBiological Applications of Optical Forces
Svoboda, K., & Block, S. M. (1994) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.bb.23.060194.001335 · Cited by 1,792
Stretching DNA with a Receding Meniscus: Experiments and Models
Bensimon, D., Simon, A. J., Croquette, V., & Bensimon, A. (1995) · Physical Review Letters · doi:10.1103/physrevlett.74.4754 · Cited by 430
Crick, F. H. C., & Klug, A. (1975) · Nature · doi:10.1038/255530a0 · Cited by 377
Research works printed but not linked: 14
- ACHTER K. E., CONFORMATION OF SINGLE-STRAND POLYNUCLEOTIDES IN SOLUTION - SEDIMENTATION STUDIES OF APURINIC ACID, BIOPOLYMERS 10, 1625 (1971). · doi:10.1002/bip.360100916
- BERMAN M. H., HYDRATION OF DNA - TAKE 2, CURRENT OPINION IN STRUCTURAL BIOLOGY 4, 345 (1994). · doi:10.1016/s0959-440x(94)90102-3
- CALLADINE R. C., UNDERSTANDING DNA MO (1992).
- CALLEN B. H., THERMODYNAMICS INTRO (1985).
- DAVIDSON N, BACTERIOPHAGE LAMBDA: 56 (1971).
- HAGERMAN J. P., INVESTIGATION OF THE FLEXIBILITY OF DNA USING TRANSIENT ELECTRIC BIREFRINGENCE, BIOPOLYMERS 20, 1503 (1981). · doi:10.1002/bip.1981.360200710
- LANDAU D. L., STATISTICAL PHYSIC 1 (1980).
- LANDAU D. L., THEORY ELASTICITY: 67 (1986).
- SAENGER W, PRINCIPLES NUCLEIC A (1984).
- SCHELLMAN A. J., STATIC CONTRIBUTIONS TO THE PERSISTENCE LENGTH OF DNA AND DYNAMIC CONTRIBUTIONS TO DNA CURVATURE, BIOPHYSICAL CHEMISTRY 55, 95 (1995). · doi:10.1016/0301-4622(94)00144-9
- SMITH B. S., BIOPHYS J 68, A250 (1995).
- SOBEL S. E., EFFECTS OF NA+ ON THE PERSISTENCE LENGTH AND EXCLUDED VOLUME OF T7-BACTERIOPHAGE DNA, BIOPOLYMERS 31, 1559 (1991). · doi:10.1002/bip.360311311
- TRIFONOV N. E., STRUCTURE EXPRESSION 3, 243 (1987).
- USSERY W. D., PROBING DNA-STRUCTURE WITH PSORALEN INVITRO, METHODS IN ENZYMOLOGY 212, 242 (1992). · doi:10.1016/0076-6879(92)12015-i
Cited by
Simultaneous micromanipulation in multiple planes using a self-reconstructing light beam
Garcés-Chávez, V., McGloin, D., Melville, H., Sibbett, W., & Dholakia, K. (2002) · Nature · doi:10.1038/nature01007 · Cited by 1,050
Principles and Applications of Nucleic Acid Strand Displacement Reactions
Simmel, F. C., Yurke, B., & Singh, H. R. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00580 · Cited by 792
Electrochemistry of Nucleic Acids
Paleček, E., & Bartošík, M. (2012) · Chemical Reviews · doi:10.1021/cr200303p · Cited by 668
Jalili, N., & Laxminarayana, K. (2004) · Mechatronics · doi:10.1016/j.mechatronics.2004.04.005 · Cited by 610
Dynamic force spectroscopy of single DNA molecules
Strunz, T., Oroszlan, K., Schäfer, R., & Güntherodt, H.-J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11277 · Cited by 580
Metadata
- Authors
- Smith, S. B., Cui, Y., & Bustamante, C.
- Venue
- Science
- Published
- 1996-02-09
- Volume
- 271
- Issue
- 5250
- Pages
- 795-799
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2081407528
- Cited by
- 2,770
- References
- 17
- FWCI
- 45.60
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Overstretching B-DNA: The Elastic Response of Individual Double-Stranded and Single-Stranded DNA Molecules. https://app.cochat.ai/papers/10.1126/science.271.5250.795
- The paper
- Smith, S. B., Cui, Y., & Bustamante, C. (1996). Overstretching B-DNA: The Elastic Response of Individual Double-Stranded and Single-Stranded DNA Molecules. Science. https://doi.org/10.1126/science.271.5250.795
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
