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Optical Rheology of Biological Cells
Abstract
A step stress deforming suspended cells causes a passive relaxation, due to a transiently cross-linked isotropic actin cortex underlying the cellular membrane. The fluid-to-solid transition occurs at a relaxation time coinciding with unbinding times of actin cross-linking proteins. Elastic contributions from slowly relaxing entangled filaments are negligible. The symmetric geometry of suspended cells ensures minimal statistical variability in their viscoelastic properties in contrast with adherent cells and thus is defining for different cell types. Mechanical stimuli on time scales of minutes trigger active structural responses.
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Citations
Cited by
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
The cytoplasm of living cells behaves as a poroelastic material
Moeendarbary, E., Valon, L., Fritzsche, M., Harris, A. R., Moulding, D. A., Thrasher, A. J., Stride, E., Mahadevan, L., & Charras, G. T. (2013) · Nature Materials · doi:10.1038/nmat3517 · Cited by 686
Viscoelastic properties of individual glial cells and neurons in the CNS
Lu, Y.-B., Franze, K., Seifert, G., Steinhäuser, C., Kirchhoff, F., Wolburg, H., Guck, J., Janmey, P., Wei, E.-Q., Käs, J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606150103 · Cited by 578
Self-citationActive behavior of the Cytoskeleton
JULICHER, F., KRUSE, K., PROST, J., & JOANNY, J. (2007) · Physics Reports · doi:10.1016/j.physrep.2007.02.018 · Cited by 476
Kasza, K. E., Rowat, A. C., Liu, J., Angelini, T. E., Brangwynne, C. P., Koenderink, G. H., & Weitz, D. A. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.12.002 · Cited by 445
Metadata
- Authors
- Wottawah, F., Schinkinger, S., Lincoln, B., Ananthakrishnan, R., Romeyke, M., Guck, J., & Käs, J.
- Venue
- Physical Review Letters
- Publisher
- American Physical Society (APS)
- Published
- 2005-03-11
- Volume
- 94
- Issue
- 9
- Pages
- 098103-098103
- ISSN
- 0031-9007 (ISSN-L)
- 1079-7114
- OpenAlex
- W1991971871
- Cited by
- 233
- References
- 0
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wottawah, F., Schinkinger, S., Lincoln, B., Ananthakrishnan, R., Romeyke, M., Guck, J., & Käs, J. (2005). Optical Rheology of Biological Cells. Physical Review Letters. https://doi.org/10.1103/physrevlett.94.098103
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