The DOI matches its Crossref record; 287 of the 287 references it cites were found in a registry or an index.
Hands-On Growth Laws Theory Cookbook
Open accessPublished version of a preprint
Abstract
This tutorial covers the emerging field of coarse-grained cellular growth modeling, and aims to bridge the gap between theoretical foundations and practical application. By adopting an original “cookbook” approach, it is designed to offer a hands-on guide for constructing and analyzing different key aspects of cellular growth, focusing on available results for bacteria and beyond. The tutorial is structured as a series of step-by-step “recipes,” and covers essential concepts, recent literature, and key challenges. It aims to empower a broad audience, from students to seasoned researchers, to replicate, extend, and innovate in this scientific area. Specifically, each section provides detailed, bare-bones models to start working in each area, from basic steady-state growth to variable environments and focusing on different key layers relevant to biosynthesis, transcription, translation, nutrient sensing, and protein degradation, links between cell cycle and growth, ending with ecological insights.
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Metadata
- Authors
- Droghetti, R., Corigliano, M., Calabrese, L., Fuchs, P., Vaidyanathan, A., Keisers, J., Micali, G., Lagomarsino, M. C., & Ciandrini, L.
- Affiliations
- IFOM (IT)
- SIB Swiss Institute of Bioinformatics (CH)
- Centre National de la Recherche Scientifique (FR)
- Humanitas University (IT)
- IRCCS Humanitas Research Hospital (IT)
- University of Milan (IT)
- ORCID
- Venue
- PRX Life
- Publisher
- American Physical Society (APS)
- Published
- 2026-03-25
- Volume
- 4
- Issue
- 1
- ISSN
- 2835-8279 (ISSN-L)
- OpenAlex
- W4417264490
- Cited by
- 5
- References
- 287
- Citations by year
- 2026: 4
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- PRX Life (publishedVersion, cc-by)
- arXiv (Cornell University) (submittedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, cc-by)
- arXiv (Cornell University)
- Funders
- Artificial Intelligence Research Center (782, 23258, 28176, 28177)
- Agence Nationale de la Recherche (ANR-21-CE45-0009)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- coarse-grained models, bacterial growth, steady-state growth, variable environments, biosynthesis, transcription, translation (biology), nutrient sensing, protein degradation, cell cycle, ecological dynamics
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